Malignant Transformation in Craniopharyngioma

Nelson, Glenn A.; Bastian, Frank O.; Schlitt, Michael; White, Robert L.

doi:10.1227/00006123-198802000-00029

Cited by 65 publications

(33 citation statements)

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“…W ith rare exceptions, [1][2][3] craniopharyngiomas are benign intracranial neoplasms that occur mainly in children but also in adults. Although no age-related differences are noted with respect to tumor size and recurrence, significant histopathologic differences have been demonstrated: Whereas adamantinomatous and papillary craniopharyngiomas occur in adulthood, pediatric examples are only rarely of the papillary type.…”

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confidence: 99%

Angiogenesis in patients with craniopharyngiomas

Vidal

Kovács

Lloyd

et al. 2002

Cancer

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The functional single‐coordinate phosphine oxide ligands (4‐diphenylaminophenyl)diphenylphosphine oxide (TAPO), (4‐naphthalen‐1‐yl‐phenylaminophenyl)diphenylphosphine oxide (NaDAPO), and 9‐[4‐(diphenylphosphinoyl)phenyl]‐9H‐carbazole (CPPO), as the direct combinations of hole‐transporting moieties, and electron‐transporting triphenylphosphine oxide (TPPO) were designed and synthesized (amines or carbazole), together with their EuIII complexes [Eu(tapo)2(tta)3] (1), [Eu(nadapo)2(tta)3] (2), and [Eu(cppo)2(tta)3] (3; TTA: 2‐thenoyltrifluoroacetonate). The investigation indicated that by taking advantage of the modification inertia of the phosphine oxide ligands, the direct introduction of the hole‐transport groups as chromophore made TAPO, NaDAPO, and CPPO obtain the most compact structure and mezzo S1 and T1 energy levels, which improved the intramolecular energy transfer in their EuIII complexes. The amorphous phase of 1–3 proved the weak intermolecular interaction, which resulted in extraordinarily low self‐quenching of the complexes. The excellent double‐carrier transport ability of the ligands was studied with Gaussian calculations, and the bipolar structure of TAPO and CPPO was proved. The great improvement of the double‐carrier transport ability of 1–3 was shown by cyclic voltammetry. Their HOMO and LUMO energy levels of around 5.3 and 3.0 eV, respectively, are the best results for EuIII complexes reported so far. A single‐layer organic light‐emitting diode of 2 had the impressive brightness of 59 cd m−2 which, to the best of our knowledge, is the highest reported so far. Both of the four‐layer devices based on pure 1 and 2 had a maximum brightness of more than 1000 cd m−2, turn‐on voltages lower than 5 V, maximum external quantum yields of more than 3 % and excellent spectral stability.

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confidence: 99%

Angiogenesis in patients with craniopharyngiomas

Vidal

Kovács

Lloyd

et al. 2002

Cancer

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“…1,3,7,14,17,18,20,23,24) The patients were aged 11 to 62 years (median 31 years), and the male to female ratio is 6:7. Radiotherapy was administered in all but the three patients with de novo tumor, and may have been one of the causes of the subsequent malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

“…Almost all craniopharyngiomas have benign features, and histologically malignant craniopharyngiomas are extremely rare. 1,3,7,14,17,18,20,23,24) Moyamoya disease is an idiopathic disease entity characterized by progressive intracranial occlusion of the anterior circulation followed by the appearance of an abnormal collateral vascular network around the circle of Willis. 15,21) Moyamoya vessels may also arise in patients with predisposed disorders such as parasellar tumors and cranial irradiation, 10,13) which is known as moyamoya syndrome, quasi moyamoya disease, akin moyamoya disease, and moyamoya-like vasculopathy.…”

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confidence: 99%

Malignant Transformation of Craniopharyngioma Associated With Moyamoya Syndrome -Case Report-

Ujifuku

Matsuo

Takeshita

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 32-year-old man presented with malignant craniopharyngioma associated with moyamoya syndrome manifesting as right visual disturbance. Magnetic resonance (MR) imaging revealed a parasellar mass lesion diagnosed as adamantinomatous craniopharyngioma. He underwent three surgical procedures and repeated courses of radiotherapy, and was able to resume his daily life. MR imaging demonstrated tumor regrowth and bilateral occlusions of the internal carotid arteries (ICAs) with basal moyamoya phenomenon, which might have been induced by irradiation and/or tumor compression, 10 years after the initial manifestations. Sufficient debulking was safely achieved via the transsphenoidal route and histological examination revealed squamous cell carcinoma, indicating malignant transformation of craniopharyngioma. The tumor relapsed after only one month, so transsphenoidal tumor debulking was tried again. However, the postoperative course was unfavorable because of intraoperative bleeding from the right ICA. Malignant transformation of craniopharyngioma may be included in moyamoya syndrome. The treatment strategy should be carefully considered in such a complicated situation.

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“…Recurrences often feature even more extensive adherence to local structures (Demaerel et al, 1993;Petito, 1996). The literature cites only 1 example of histologically malignant transformation of a craniopharyngioma (Nelson et al, 1988), an adam antinom atous tumor. In addition to remote metastases (Gupta et al, 1999;Ito et al, 2001), rare examples of craniopharyngioma arise in ectopic locations, including the pineal gland (Solarski et al, 1978), sphenoid bone (Cooper and Ransohoff, 1972), cerebellopontine angle (Gökalp et al, 1991), optic chiasm (Duff and Levine, 1983), and nasopharynx (Majlessi et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Metastatic papillary craniopharyngioma: Case study and study of tumorangiogenesis

Elmaci¹,

Kurtkaya-Yapıcıer²,

Ekinci³

et al. 2002

Neuro-Oncology

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2Abbreviations used are as follows: ER, estrogen receptor; MVD, microvascular density; PR, progesterone receptor; VEGF, vascular endothelial growth factor.We report a case of suprasellar papillary craniopharyngioma metastatic to the temporoparietal region 2 years after its initial resection. The literature documents examples of craniopharyngioma recurrences along the surgical tract, as well as remote ipsi-and contralateral metastases via cerebrospinal uid seeding. Ours is the second report of a craniopharyngioma of papillary type to exhibit metastatic behavior. The tumor spread opposite the side of craniotomy. Although a rare occurrence, it con rms the limited capacity of histologically benign craniopharyngiomas to undergo meningeal seeding, likely the result of surgical manipulation. Immunohistochemical demonstration of increased microvascular density and vascular endothelial growth factor expression, as well as a high vascular endothelial growth receptor (VEGFR2) signal by in situ hybridization, suggests that tumor vascularity facilitated angiogenesis and may have been involved in the establishment and growth of the metastatic deposit. Neuro-Oncology 4, 123-128, 2002 (Posted to Neuro-Oncology [serial online], Doc. 01-046, February 18, 2002 C raniopharyngiomas are assumed to arise from epithelial rests of the normally involuted craniopharyngeal duct (Burger and Scheithauer, 1994).Histologically, they occur in 2 easily recognized forms. Most are adamantinomatous tumors, occurring more often in children than in adults and radiographically characterized by calci cation. Histologically, they resemble adamantinoma of the jaw. Occurring less frequently is the papillary variant, which lacks calci cation and consists of sheets and crude fronds of simple, nonkeratinizing squamous epithelium. Either tumor may be cystic, solid, or both (Burger et al., 1994). Despite their benign histology, craniopharyngiomas may rarely recur as a result of implantation along the operative tract or as remote deposits or metastases due to cerebrospinal uid spread (Barloon et al., 1988;Gupta et al., 1999;Israel and Pomeranz, 1995;Ito et al., 2001;Lee et al., 1999;Malik et al., 1992;Ragoowansi and Piepgras, 1991). Our case is an example of the latter-a leptomeningeal metastasis opposite the side of the craniotomy that presented 2 years after removal of the primary tumor. It represents the second papillary craniopharyngioma to behave in this manner. No doubt surgical manipulation may be implicated in its spread. However, the possibility that angiogenesis played a role in facilitating the establishment and growth of the deposit is explored by a study of MVD 2 and of the expression of VEGF and its receptor VEGFR2. Case Study and PathologyA 62-year-old woman complained of headaches, dizziness, and visual disturbance. Both the general physical and neurologic examinations were normal. CT and MRI of the sellar region revealed a cystic and noncalcified suprasellar mass (3.8 ´3.5 ´2.5 cm) with rim enhancement (Fig. 1, left). The preoperative diagnos...

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Malignant Transformation in Craniopharyngioma

Cited by 65 publications

References 0 publications

Angiogenesis in patients with craniopharyngiomas

Angiogenesis in patients with craniopharyngiomas

Malignant Transformation of Craniopharyngioma Associated With Moyamoya Syndrome -Case Report-

Metastatic papillary craniopharyngioma: Case study and study of tumorangiogenesis

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