Malignant transformation of oral leukoplakia: a follow-up study

Jayasooriya, Primali Rukmal; Dayaratne, K.; Dissanayeke, Uvasara; Warnakulasuriya, Saman

doi:10.1007/s00784-020-03322-4

Cited by 33 publications

(36 citation statements)

References 30 publications

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“…c If a patient has other sites of oral leukoplakia in addition to tongue, the patient will be categorized as "yes" malignant changes of OLK, similar conflict between the published reports was also found; oral habits were significant factors in some academic works [5,29,39] and non-significant in others [21,38,[40][41][42]. In the present study, oral habits were not factors related to the recurrence or malignant transformation of oral tongue leukoplakia.…”

Section: Discussionsupporting

confidence: 68%

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

et al. 2021

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Objectives The tongue is identified as a high-risk site for oral leukoplakia and malignant transformation. The purpose of this study is to investigate the clinicopathological characteristics and treatment outcomes of tongue leukoplakia and assess the factors related to recurrence and malignant transformation. Materials and methods One hundred and forty-four patients who received carbon dioxide laser surgery for tongue leukoplakia from 2002 to 2019 were analyzed statistically. Results The follow-up period was 54.90 ± 54.41 months. Thirty patients showed postoperative recurrence (20.83%), and 12 patients developed malignant transformation (8.33%). The annual transformation rate was 2.28%. Univariate analysis showed that a history of head and neck cancer, size of lesion area, clinical appearance, and pathology were significant factors for both recurrence and malignant transformation. In the multivariate logistic regression, a history of head and neck cancer and size of lesion area were independent prognostic factors for recurrence, and a history of head and neck cancer was the only independent factor for postoperative malignant change. Conclusions Clinicians should adopt more aggressive strategies for tongue leukoplakia patients with a history of head and neck cancer. Clinical relevance These results may help clinicians gain a better understanding of oral tongue leukoplakia.

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Section: Discussionsupporting

confidence: 68%

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

et al. 2021

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“…Moreover, a study by Rubert et al provides us with information that gender may also influence the risk of malignant transformation of oral leukoplakia. In the study, 57.1% of cases were diagnosed among female patients and 42.9% among male patients, which may lead to a conclusion that female patients might be more prone to malignant transformation of oral leukoplakia [ 29 ], which is the opposite result of the research conducted by Jayasooriya et al [ 28 ], Wang et al [ 27 ], and meta-analysis prepared by Matulić et al, which also revealed that there were no statistically significant differences in malignant transformation of oral leukoplakia between male and female patients [ 30 ]. Nevertheless, returning to the statement that the age of patients may influence the clinical symptoms of leukoplakia, the study by Rupert et al also seems to confirm this [ 29 ].…”

Section: Discussionmentioning

confidence: 95%

“…Jayasooriya et al, similarly to our results, also found men to be more affected by leukoplakia: in a group of 93 cases of leukoplakia, men predominated with a ratio of men to women of 3.5: 1.That being said, this study revealed that there was no statistically significant difference in the frequency of malignant transformation of oral leukoplakia connected with gender. In this study the age of patients also did not influence the risk of malignant transformation [ 28 ]. On the other hand, in retrospective research conducted by Rubert et al, in a group of 412 patients diagnosed with oral leukoplakia, females (281) predominated over males (131) [ 29 ].…”

Section: Discussionmentioning

confidence: 98%

The Analysis of the Frequency of Leukoplakia in Reference of Tobacco Smoking among Northern Polish Population

Kusiak

Maj

Cichońska

et al. 2020

IJERPH

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Objective: The aim of the study was an updated analysis of the frequency of leukoplakia in reference to tobacco smoking among the northern Polish population. Material and Methods: Medical records of 5720 patients who suffer from abnormalities and oral mucosa diseases between January 2015–December 2018 were analyzed. Among them, 416 medical charts of patients with leukoplakia were selected. The study group consisted of 196 women and 220 men aged between 21–86 years (average 45.6 years). The analysis was conducted in terms of age, gender, and smoking tobacco. The basic criterion for inclusion in the study was the presence of oral leukoplakia confirmed by histopathological examination, recorded in the chart. Information about the patient’s active smoking was obtained from documented medical interviews. An active smoker was defined as a patient who smoked 10 or more cigarettes a day for at least the previous six months. The study used parametric and non-parametric statistical methods. Results: The highest incidence of leukoplakia was found in the age group 41–60 (46.6%), where the vast majority were active smokers (85.1%), and mostly men (86.2%). However, among patients with leukoplakia, the highest prevalence of smoking was found in the age group 21–40 years (86.8%) in women, where out of 38 patients with leukoplakia, 33 were active smokers. More patients with leukoplakia were observed in groups of smokers and it was statistically significant. Homogeneous form was the most commonly diagnosed form of leukoplakia in our study; it was found in almost 95% of cases. Leukoplakia was mainly observed on the cheeks. Changes on the gums, the alveolar process or the bottom of the tongue and mouth were rarely found. Conclusion: Our studies revealed that there is a statistically significant correlation between tobacco smoking and the presence of oral leukoplakia among the northern Polish population. It should be noted that dentists, in particular, are capable of early diagnosis and implementation of appropriate treatment of leukoplakia and, most often, crucial elimination of the main risk factor, which is smoking, and the implementation of effective tobacco control interventions.

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“…1,2 Oral leukoplakia (OLK) is the most prevalent OPMDs recognized by the World Health Organization (WHO). 3,4 Based on observational 24 studies, Warnakulasuriya et al 5,6 estimated OLK overall (mean) malignant transformation rate to 3.5% (405/11423), and the malignant transformation may range from 0.13% to 34.0% increasing with the degree of epithelial dysplasia. [7][8][9] The mechanism of OLK progression remains unclear, which seriously affects clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Peroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy

Lu¹,

Li²,

Chen³

et al. 2021

OTT

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Purpose: Cellular senescence is a physiological phenomenon by which cells irreversibly lose their proliferative potential. It is not clear whether senescent cells are related to malignant transformation in oral precancerous lesions. The role of peroxiredoxin1 (Prx1)induced cell senescence in OLK malignant transformation has not been reported. The aim of this study is to investigate the role and mechanism of cell senescence in oral carcinogenesis. Methods: In this study, 4-nitro-quinoline-1-oxide (4NQO) induced tongue carcinogenesis model in Prx1 +/+ and Prx1 +/mice and dysplastic oral keratinocyte (DOK) were used. Prx1 knockdown DOK cells were harvested with shRNA injection, and cell senescence was detected via the senescence-associated β-galactosidase (SA β-gal) assay. The senescence and mitophagy-related proteins were observed by immunohistochemistry (IHC), Western blot and qRT-PCR. The binding of Prx1 with prohibitin 2 (PHB2) and light chain 3 (LC3) was predicted via ZDOCK and measured in mice by Duolink analysis. Results: Histologically, 4NQO treatment induced epithelial hyperplasia, dysplasia (mild, moderate and severe), carcinomas in situ and oral squamous cell carcinoma (OSCC) in mouse tongue mucosa. The malignant transformation rate in Prx1 +/mice (37.5%) was significantly lower compared with Prx1 +/+ mice (57.1%). In Prx1 +/+ mice, a higher number of senescent cells and greater expression of p53 and p21 were observed in hyperplastic and dysplastic tongue tissues when compared with those in OSCC tissues. Prx1 knockdown induced a greater number of senescent cells in hyperplastic tissues, and DOK cells accompanied cell cycle arrest at the G1 phase and PHB2/LC3II downregulation. Prx1 was predicted to dock with PHB2 and LC3 via ZDOCK, and the interactions were confirmed by in situ Duolink analysis. Conclusion: Prx1 silencing inhibits the oral carcinogenesis by inducing cell senescence dependent on mitophagy.

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Malignant transformation of oral leukoplakia: a follow-up study

Cited by 33 publications

References 30 publications

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

The Analysis of the Frequency of Leukoplakia in Reference of Tobacco Smoking among Northern Polish Population

Peroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy

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