Malignant transformation of oral squamous cell papilloma: a case report

Abstract

Highlights This case report contributes to the growing pool of reports concerning human papillomavirus (HPV) associated oral cancers. There is a paucity of information in the literature regarding the malignant transformation of oral squamous cell papilloma (SCP). The authors present a unique case of virus-associated cancer highlighting its progress and implications. Immunocompromised patients and the elderly are at higher risk of malignancy and require closer observation.

Squamous Papilloma of the Soft Palate: A Case Report

“…According to the recent World Health Organization (WHO) classification, oral squamous papilloma is a benign hyperplastic exophytic localized overgrowth with a verrucous or cauliflower-like appearance with a sessile or pedunculated base [ 9 ]. The lesion measures approximately 1 cm in size, and the color may vary from pink to white depending on the level of keratinization and vascularity [ 10 ]. Oral squamous papilloma is characterized by slow growth and nonaggressive behavior and is commonly found in the tongue, palate, uvula, vermilion border of the lips, and gingiva.…”

“…Oral squamous papilloma is characterized by slow growth and nonaggressive behavior and is commonly found in the tongue, palate, uvula, vermilion border of the lips, and gingiva. However, lesions present on the gingiva or those larger than 10 mm are at a higher risk of transforming into malignancy [ 10 ].…”

“…Asymptomatic lesions are a common finding when intraoral evaluation is performed, but in some cases, the lesion shows a malignant resemblance or transformation to oral squamous cell carcinoma [ 1 ]. Therefore, they should be detected early and carefully analyzed histopathologically [ 10 ]. The present study’s age of occurrence, gender predilection, and lesion characteristics both clinically and histologically agree with the literature.…”

Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity—An Update

“…The risk factors of HNSCC HPV negative are represented mainly by chronic alcoholism, cigarette smoking, inadequate nutrition, poor oral hygiene and also infection with other microorganisms such as Candida albicans and the Epstein-Barr virus [12], UV and ionizing radiation and also genetic predisposition [4,[132][133][134]. Actually, a change in the balance between HPV-negative and HPV-positive HNSCC was noticed, in part because of the decreased use of tobacco and alcohol and increased awareness and enhanced molecular diagnostic methods of HPV infection [15,135].…”

Papiloma oral de células escamosas na papila interincisiva: Revisão da literatura em um relato de caso

“…La escisión quirúrgica simple de la base de la lesión junto con una fracción del tejido circundante a la lesión es comúnmente el tratamiento de elección, el cual suele ser calificado como un método beneficioso que permite un diagnóstico postquirúrgico certero. (Zahid et al,2022;Betz, 2019;Andrei et al, 2022;Orrù et al, 2019;Ghassan, 2023;Araújo et al, 2019;Babaji et al, 2014;Tebcherany et al, 2022) Algunas variantes de tratamiento del PCE comprenden: uso de bisturí de resonancia molecular cuántica, ablación con láser, crioterapia, ablación por radiofrecuencia o a partir de terapia fotodinámica, aplicación de ácido salicílico o inyecciones intralesionales de interferón (Zahid et al,2022;Orrù et al, 2019;Babaji et al, 2014;Hassan et al, 2020) Los rasgos clínicos y las características de la lesión, las cualidades de cada paciente y la experticia del profesional, son parámetros importantes a considerar al momento de escoger el tipo de tratamiento a realizar (Orrù et al, 2019).…”