Malignant Transformation of Respiratory Papillomatosis in a Solid-Organ Transplant Patient: Case Report and Literature Review

Azadarmaki, Roya; Lango, Miriam

doi:10.1177/000348941312200708

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Gastroesophageal reflux and immunosuppression may also be aggravating factors for patients with papillomatosis [15, 16]. In the present case, no signs of reflux or immunosuppression were found.…”

Section: Discussionmentioning

confidence: 42%

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

El‐Achkar

Duarte

Saggioro

et al. 2018

Case Reports in Otolaryngology

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Background The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. Case Report A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11. The final diagnosis was SCC arising from LP. The patient underwent surgical treatment. After 36 months of follow-up, no signs of recurrence were observed. Results The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis. Conclusions LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.

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Section: Discussionmentioning

confidence: 42%

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

El‐Achkar

Duarte

Saggioro

et al. 2018

Case Reports in Otolaryngology

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“…Bronchoscopic pictures were suggestive of papillary lesion although association with HPV can't be commented upon as patient refused for further testing. A literature review of RRP case reports revealed that patients usually have the diagnosis of RRP many years before evidence of malignant transformation (9)(10)(11)(12). In contrast, our patient had evidence of malignant transformation about six months after diagnosis of respiratory papillomatosis.…”

Section: Discussionmentioning

confidence: 57%

Respiratory papillomatosis with small cell carcinoma: case report and brief review

Sharma¹,

Jha²,

Janapati³

et al. 2020

Southwest J Pulm Crit Care

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Respiratory Papillomatosis is a rare disease in which multiple exophytic squamous wart-like lesions occur within the respiratory tract. Recurrent Respiratory Papillomatosis (RRP) has the potential for malignant transformation to squamous lung cell carcinoma with a dismal prognosis. Most of the prior literature has shown malignant transformation of respiratory papillomatosis into squamous cell carcinoma. Here, we report a rare presentation of respiratory papillomatosis coexisting with small cell carcinoma and a review of relevant literature.

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“…The higher risk of carcinoma reported in elderly patients can be related to genetic susceptibility contributing to the phenotype [ 13 , 23 ]. The association of malignancy and immunosuppressive therapy is mediated through several pathogenic direct and indirect factors [ 24 , 25 ]. Therefore, the dose of immunosuppression shall be adjusted carefully to reduce the risk of malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of oral squamous cell papilloma: a case report

Saad

Halawa

Zidan

et al. 2020

International Journal of Surgery Case Reports

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Highlights This case report contributes to the growing pool of reports concerning human papillomavirus (HPV) associated oral cancers. There is a paucity of information in the literature regarding the malignant transformation of oral squamous cell papilloma (SCP). The authors present a unique case of virus-associated cancer highlighting its progress and implications. Immunocompromised patients and the elderly are at higher risk of malignancy and require closer observation.

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Malignant Transformation of Respiratory Papillomatosis in a Solid-Organ Transplant Patient: Case Report and Literature Review

Cited by 7 publications

References 20 publications

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

Respiratory papillomatosis with small cell carcinoma: case report and brief review

Malignant transformation of oral squamous cell papilloma: a case report

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