Malignant, transplantable, giant cell tumors of peri-articular connective tissues in Syrian golden hamsters (Mesocricetus auratus)

Abstract

Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9

Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

“…The latter tissue presented 2 features of diagnostic significance: it was composed of a mixture of 3 cell types, namely elongated or plump spindle-shaped cells, rounded or polygonal cells resembling histiocytes or macrophages, and scattered giant cells; and the neoplastic cells were arranged in a multinodular fashion around lymphatics and blood vessels. These features are consistent with those described for malignant giant-cell tumour of soft parts 1,3,6,10,13,14,16 . There is much controversy as to the cell of origin of this tumour, but the present consensus of opinion is that it arises from pluripotential undifferentiated mesenchymal cells, which then differentiate to fibroblasts, histiocytes or intermediate cell types 3,11,13 .…”

“…Of interest in the tumour reported here was the presence of neoplastic polygonal and giant cells clustered around and invading lymphatics and blood vessels with consequent development of numerous emboli. This feature has been described as a common occurrence in the deep form of malignant histiocytomas in humans 11 , but except for reports of 6 cases in horses and 3 in Syrian golden hamsters 14,16 , does not seem to have been reported in cases of malignant fibrous histiocytoma in domestic animals. We believe this feature to be relatively unique to the deep variant of this tumour type, and one of the principal reasons for its rapid spread along the contours of the femoral bone and metastasis to the regional lymph node, as seen radiographically and histologically in the present case.…”

“…Malignant fibrous histiocytoma (malignant giant-cell tumour of soft parts) is a rare extraskeletal neoplasm of the superficial and deep connective tissues, occurring in humans and animals. In the veterinary literature it has been reported in a mule 5 , 7 horses 6,14 , 12 cats [1][2][3][6][7][8][9]12,15,17 , 3 dogs 13 and 3 Syrian golden hamsters 16 . The 3 dog cases formed part of a pathology collection with no published clinical reports of the condition.…”