Malignant tumor, of the gastrointestinal stromal tumor type, in the greater omentum

Suzuki, Kazufumi; Kaneko, Gengo; Kubota, K; Horigome, Naoto; Hikita, Hitoshi; Senga, Osamu; Miyakawa, M; Shimojo, Hisashi; Uehara, Takeshi; Itoh, Nobuo

doi:10.1007/s00535-003-1182-z

Cited by 24 publications

(8 citation statements)

References 17 publications

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“…These symptoms are frequently associated with primary hepatic tumors, such as hepatocellular carcinoma or hepatic adenoma, which have greater vascularity than metastatic lesions. Since the first reported case of a ruptured hepatic metastasis from GIST by Suzuki et al in 2003, only 2 additional cases (one in the greater omentum and one in the jejunum) 7 , 8 have been documented in the English literature. At imaging, the diagnosis of a hemorrhagic metastasis is suggested if blood is identified in one or more liver lesions in a patient with known hepatic metastases or a known primary hepatic tumor.…”

Section: Discussionmentioning

confidence: 99%

A Spontaneously Ruptured Hepatic Metastasis From a Gastric Gastrointestinal Stromal Tumor That Presented as Hemoperitoneum

Yoon

2013

Journal of Investigative Medicine High Impact Case Reports

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Spontaneous hepatic hemorrhage is a rare condition that may be caused by an underlying hepatic tumor, most commonly hepatocellular carcinoma or hepatic adenoma. A spontaneous rupture of a hepatic metastasis from a gastric gastrointestinal stromal tumor is also extremely rare, and the majority of affected patients present with hypovolemic shock or an acute abdomen. In this article, we report the case of a 65-year-old man with a spontaneous rupture of a hepatic metastasis from a gastric gastrointestinal stromal tumor that presented as hypovolemic shock. Cross-sectional imaging studies (computed tomography or magnetic resonance imaging) play a significant role in the diagnosis of this condition and guides its management.

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Section: Discussionmentioning

confidence: 99%

A Spontaneously Ruptured Hepatic Metastasis From a Gastric Gastrointestinal Stromal Tumor That Presented as Hemoperitoneum

Yoon

2013

Journal of Investigative Medicine High Impact Case Reports

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“…The remaining 3%–5% of c-KIT-negative GISTs is positive for PDGFRα mutations and PDGFRα mutations, and there is a small percentage of wild-type c-KIT mutations 22,23. The mutations in oncogenic KIT genes are present in exons 9, 11, 13, and 17 24,25. The mutations in exon 11 are most commonly deletions and substitutions, whereas duplications and insertions are less common.…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions

Karanikas¹,

Machairiotis²,

Stylianaki³

et al. 2012

OTT

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We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.

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“…In addition to PDGFRα mutations there is a small percentage of wild-type c-KIT mutations 6,7. The oncogenic mutations in the c-KIT gene are located on exons 9, 11, 13, and 17 8,9. It is known that the most common mutations on exon 11 are deletions and substitutions, with duplications and insertions less common.…”

Section: Role Of C-kit and Platelet-derived Growth Factor α (Pdgfrα)mentioning

confidence: 99%

Gastrointestinal stromal tumor mesenchymal neoplasms: the offspring that choose the wrong path

Machairiotis

Kougioumtzi²,

Stylianaki³

et al. 2013

JMDH

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Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the pluripotential mesenchymal stem cells, which differentiate into interstitial Cajal cells. They are usually located in the upper gastrointestinal track. These tumors are typically defined by the expression of c-KIT (CD117) and CD34 proteins in the tumor cells. A small percentage of these tumors is negative for c-KIT. The neoplasms are positive for platelet-derived growth factor α (PDGFα) mutations. In addition to PDGFRα mutations, wild-type c-KIT mutations can also be present. The therapeutic approach to locally developed gastrointestinal stromal tumors is surgical resection, either with open or laparoscopic surgery. In case of systemic disease, molecular pharmacologic agents such as imatinib and sunitinib are used for treatment. These agents block the signaling pathways of neoplastic-cell tyrosine kinases, interfering in their proliferation and causing apoptosis.

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Malignant tumor, of the gastrointestinal stromal tumor type, in the greater omentum

Cited by 24 publications

References 17 publications

A Spontaneously Ruptured Hepatic Metastasis From a Gastric Gastrointestinal Stromal Tumor That Presented as Hemoperitoneum

A Spontaneously Ruptured Hepatic Metastasis From a Gastric Gastrointestinal Stromal Tumor That Presented as Hemoperitoneum

Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions

Gastrointestinal stromal tumor mesenchymal neoplasms: the offspring that choose the wrong path

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