Malignome des Larynx

Laryngeal cancer is one of the most frequent types of head and neck cancer. The incidence is decreasing for men but still increasing for women. The incidence in Germany is about 5-7/100,000 persons/year for men and 0.6-0.8/100,000 persons/year for women. Due to the increased life expectancy, the average age of patients diagnosed with laryngeal cancer is increasing. Nevertheless, adequately prepared older patients treated by standard protocols can have the same survival and complication rates as younger patients. Tobacco and alcohol are still the primary risk factors responsible for disease in at least 80% of the patients. Despite the many new diagnostic tools, still more than half of the patients are diagnosed at an advanced tumor stage. Survival rates have not improved significantly in the last 10 years in Germany, and the average 5-year overall survival rate is about 60%. However, a decrease in the survival rate, as observed in the USA, cannot be confirmed for Germany.

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The impact of laryngeal dysplasia on the development of laryngeal squamous cell carcinoma

Lüers

Sircar

Drebber

et al. 2013

Eur Arch Otorhinolaryngol

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The aims of this study were to investigate the clinical course of patients with laryngeal dysplasia of various grades after surgical removal and analyze the percentage and time frame in which laryngeal dysplasia progresses to invasive carcinoma. The files of patients with surgical removal of laryngeal dysplasia and at least two microlaryngoscopies during a 10-year period were retrospectively reviewed. In total, 210 microlaryngoscopies of 70 adult patients were analyzed. Overall, of 295 biopsies taken 21 % showed no dysplastic alterations, 69 % showed dysplasia and 10 % showed invasive carcinoma, which had developed out of a laryngeal dysplasia. Dysplasia grades were equally distributed within the first three microlaryngoscopies (P = 0.31, P = 0.50, P = 0.55). The risk for developing laryngeal cancer out of laryngeal dysplasia showed no statistical correlation to the initial dysplasia grade (P = 0.26). On average, the malignant conversion took 127 weeks (mild dysplasia = 117 weeks; moderate dysplasia = 135 weeks; severe dysplasia = 82 weeks) (P = 0.27). Patients with laryngeal dysplasia are an inhomogeneous group and the grade of laryngeal dysplasia alone seems to be an insufficient prognostic factor for the development of laryngeal cancer.

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Malignome des Larynx

Abstract: Merke: Larynxmalignome beschreiben in der überwiegenden Mehrzahl der Fälle Plattenepithelkarzinome des Kehlkopfs (über 90%).

Cited by 6 publications

References 10 publications

Erkrankungen in der HNO-Heilkunde

Erkrankungen in der HNO-Heilkunde

Larynxkarzinom

The impact of laryngeal dysplasia on the development of laryngeal squamous cell carcinoma

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