Malnutrition during lactation changes growth hormone mRNA expression in offspring at weaning and in adulthood

Moura, Egberto Gaspar de; Lisboa, Patrícia Cristina; Custódio, Claudia Mota; Nunes, Maria Tereza; Souza, Kely de Picoli; Passos, M. C. F.

doi:10.1016/j.jnutbio.2006.04.002

Cited by 41 publications

(42 citation statements)

References 43 publications

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“…We evidenced that adverse situations early in life, such as malnutrition , Dutra et al 2003, Fagundes et al 2007, de Moura et al 2007) and hormonal (de Oliveira Cravo et al 2002, Teixeira et al 2003, Lins et al 2005, Toste et al 2006a,b, Bonomo et al 2007) changes during lactation, could permanently affect the progeny. Maternal energy malnutrition during lactation programs for a higher body weight in adulthood; however, protein malnutrition programs for a lower body weight in the adult offspring (Passos et al 2000.…”

Section: Introductionmentioning

confidence: 71%

Prolactin inhibition at the end of lactation programs for a central hypothyroidism in adult rat

Bonomo

Lisboa²,

Passos³

et al. 2008

Journal of Endocrinology

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Malnutrition during lactation is associated with hypoprolactinemia and failure in milk production. Adult rats whose mothers were malnourished presented higher body weight and serum triiodothyronine (T 3 ). Maternal hypoprolactinemia at the end of lactation caused higher body weight in adult life, suggesting an association between maternal prolactin (PRL) level and programming of the offspring's adult body weight. Here, we studied the consequences of the maternal PRL inhibition at the end of lactation by bromocriptine (BRO) injection, a dopaminergic agonist, upon serum TSH and thyroid hormones, thyroid iodide uptake, liver mitochondrial a-glycerophosphate dehydrogenase (mGPD), liver and pituitary de-iodinase activities (D1 and/or D2), and in vitro post-TRH TSH release in the adult offspring. Wistar lactating rats were divided into BRO -injected with 1 mg/twice a day, daily for the last 3 days of lactation, and C -control, saline-injected with the same frequency. At 180 days of age, the offspring were injected with 125 I i.p. and after 2 h, they were killed. Adult animals whose mothers were treated with BRO at the end of lactation presented lower serum TSH (K51%), T 3 (K23%), and thyroxine (K21%), lower thyroid 125 I uptake (K41%), liver mGPD (K55%), and pituitary D2 (K51%) activities, without changes in the in vitro post-TRH TSH release. We show that maternal PRL suppression at the end of lactation programs a hypometabolic state in adulthood, in part due to a thyroid hypofunction, caused by a central hypothyroidism, probably due to decreased TRH secretion. We suggest that PRL during lactation can regulate the hypothalamus-pituitary-thyroid axis and programs its function.

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Section: Introductionmentioning

confidence: 71%

Prolactin inhibition at the end of lactation programs for a central hypothyroidism in adult rat

Bonomo

Lisboa²,

Passos³

et al. 2008

Journal of Endocrinology

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“…Thus, it is possible that the lower body mass of this group is due to a loss of muscle mass. In addition, lower pituitary growth hormone mRNA has been reported in programmed PR offspring (de Moura et al 2007). Because growth hormone increases protein synthesis in muscle, this finding may also explain the body composition changes of the programmed mice in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Table I shows the composition of the diets (Reeves et al 1993). The PR diet was produced in our laboratory, using the standard commercial diet for rodents (NuvilabNuvital Nutrientes SA, PR, Brazil) by replacing parts of the protein with cornstarch (Lisboa et al 2003, de Moura et al 2007, Fagundes et al 2009). The amount of cornstarch that was added compensated for the decrease in energy content due to protein reduction.…”

Section: Methodsmentioning

confidence: 99%

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Corrêa

Lisboa

Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Rats. [grupo-controle: 12,00 (9,(0)(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)00) dias; POFG=9,50 (9,(0)(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)00) dias] e queda livre [grupo-controle:18,00 (17,00); POFG=16,00 (13,(0)(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)…”

Section: Resultsunclassified

“…Hence, low protein intake affects pregnancy and lactation performance, and the protein content of the dam's milk 5,6 . There are numerous reports in the literature about the relationship between protein quality 7 and quantity 2,5,6,8 in the dam's diet and the changes it causes on the somatic, metabolic and functional systems of the dam and her offspring.…”

Section: Introductionmentioning

confidence: 99%

Experimental diet based on the foods listed in the Family Budget Survey is more detrimental to growth than to the reflex development of rats

et al. 2013

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OBJECTIVE: The present study assessed the pregnancy and lactation performances of rats fed an experimental diet based on the foods listed in the Family Budget Survey (Pesquisa de Orçamento Familiar) 2002/2003 and the impact of said diet on the growth and development of the pups until weaning. METHODS: Wistar (n=12) rats were randomly divided into two groups: a control group (control group, n=6) fed a commercial chow (Labina®, Brazil) and an experimental group (n=6) fed the Family Budget Survey diet during the entire pregnancy and lactation period. All animals had free access to food and water during the entire study period. RESULTS: The Family Budget Survey diet increased the duration of pregnancy (control group=21.00±0.00; POFG=21.57±0.55, p=0.025) and made the dams lose weight during the lactation period (control group=27.92±18.47g; POFG=-15.66±16.90g). The Family Budget Survey group presented low food, energy and nutrient intakes during pregnancy, which became even lower during lactation. Pups from Family Budget Survey dams presented lower body weight at weaning (control group=52.38±4.49g; POFG=39.88±2.78g, p=0.001) and lower nose-to-anus length (control group= 117.37±0.64mm; POFG=125.62±0.96mm, p=0.001). However, some physical milestones and reflexes occurred earlier, such as the placing response reflex [control group= 12.00 (9.00-15.00) days; POFG=9.50 (9.00-14.00) days] aerial righting reflex [control group=18.00 (17.00-20.00) days; POFG=16.00 (13.00-18.00) days] and unfolding of the external ear [control group=3.00 (3.00-3.00) days; POFG=2.00 (2.00-3.00) days]. CONCLUSION: The Family Budget Survey diet seems to be more detrimental to the physical growth of the pups than to their brain growth, according to the assessed reflexes and physical milestones and measures. This may be due to the low protein content of the diet for rat reproduction and growth combined with adequate fat and essential fatty acid contents. Providing an adequate amount of protein to the Family Budget Survey diet may normalize pup growth.

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Malnutrition during lactation changes growth hormone mRNA expression in offspring at weaning and in adulthood

Cited by 41 publications

References 43 publications

Prolactin inhibition at the end of lactation programs for a central hypothyroidism in adult rat

Prolactin inhibition at the end of lactation programs for a central hypothyroidism in adult rat

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Experimental diet based on the foods listed in the Family Budget Survey is more detrimental to growth than to the reflex development of rats

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