Malposition of unerupted mandibular second premolar associated with agenesis of its antimere

Shalish, Miri; Peck, Sheldon; Wasserstein, Atalia; Peck, Leena

doi:10.1067/mod.2002.120399

Cited by 45 publications

(47 citation statements)

References 12 publications

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“…rotated parallel [sic] to the tooth row, a trait that seems to be unrecorded in any other hominin.'' However, dental rotation is common in modern H. sapiens, typically indicating developmental abnormality, crowding, or agenesis (71). No other maxillae are known from the Liang Bua Cave sample, but it is highly unlikely that any species of Homo normatively would have bilaterally rotated upper premolars because this anomaly clearly would interfere with occlusion.…”

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confidence: 99%

Pygmoid Australomelanesian Homo sapiens skeletal remains from Liang Bua, Flores: Population affinities and pathological abnormalities

Jacob

Indriati

Soejono

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

170

168

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confidence: 99%

Pygmoid Australomelanesian Homo sapiens skeletal remains from Liang Bua, Flores: Population affinities and pathological abnormalities

Jacob

Indriati

Soejono

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

170

168

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“…Both agenesis and clefting have been shown to be associated with the MnP2 malposition anomaly. 1,15 Results of this work, along with results from Shalish et al, 1,15 associate the MnP2 angulation anomaly with PDC, agenesis, and clefting, suggesting the MnP2 anomaly is a variable in a genetically related group of dental anomalies likely to be associated with MSX1 mutations. It is likely that the MnP2 anomaly may ap-pear in combination with any other of these inter-associated anomalies (eg, infraocclusion, mesially ectopic maxillary first molar, tooth transposition, tooth rotation, tooth size reduction, peg-shaped maxillary lateral incisor), perhaps because all of these anomalies are caused by the same mechanism.…”

Section: Discussionmentioning

confidence: 91%

“…1 In both samples, panoramic radiographs were used to trace each MnP2, along with the neighboring mandibular first molar, the deciduous second molar, and a tangent to the inferior border of the mandibular body on that side. The long axis of the MnP2 was determined as the line connecting the uppermost point of the pulp with the point bisecting the distance between the mesial and distal points of the apex.…”

Section: Methodsmentioning

confidence: 99%

“…In a recent such study, it was discovered that exaggerated distoangular malposition of the unerupted mandibular second premolar (MnP2) was as-sociated with agenesis of its antimere. 1 This finding relates the MnP2 malposition to a group of tooth development abnormalities of possible common genetic origin, including agenesis (hypodontia), peg-shaped maxillary lateral incisors, small maxillary lateral incisors, palatally displaced canines (PDC), infraocclusion of primary molars, and transpositions of various teeth. [2][3][4][5][6][7][8] Accumulated evidence on associations among this group go well beyond coincidence, 8 suggesting that they are part of a broader genetically related pattern of dental anomalies.…”

Section: Introductionmentioning

confidence: 99%

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Malposition of Unerupted Mandibular Second Premolar in Children with Palatally Displaced Canines

Shalish

Chaushu

Wasserstein

2009

The Angle Orthodontist

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Objective: To test the hypotheses that (1) the distal angulation of unerupted mandibular premolar (MnP2) is significantly greater in children with palatally displaced canines (PDC) than in those in a control sample; and (2) delayed tooth formation is significantly more frequent in children with both malposed MnP2 and PDC than in children with PDC only. Materials and Methods: We examined retrospectively panoramic radiographs from 43 patients with PDC who had no previous orthodontics. A control sample consisted of age-and sex-matched patients. The distal angle formed between the long axis of MnP2 and the tangent to the inferior border was measured. Dental age was evaluated using the Koch classification. Results: A significant difference was observed between the mean inclination of the right side MnP2 in the PDC group (75.4 degrees) and that of the control group (85.8 degrees). This difference was highly statistically significant (P Ͻ .0001). The same evaluation was carried out for the left side, with similar results. The average dental age was found to be delayed in patients who showed both abnormalities (malposed MnP2 and PDC) compared with patients who showed the PDC anomaly only. Conclusion: Both hypotheses are retained. Statistically, PDC and MnP2 malposition are significantly associated suggesting a common genetic etiology, despite taking place on opposite jaws. While the presence of PDC or MnP2 anomaly has been associated with a delay in tooth formation, we find the presence of both anomalies to show a more profound delay. Our findings suggest a delay in tooth formation as a possible common genetic mechanism for these 2 malposition anomalies. (Angle Orthod. 2009;79:796-799.)

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“…1 This finding relates the MnP2 malposition to a group of tooth developmental abnormalities of possible common genetic origin, including agenesis (hypodontia), peg-shaped maxillary lateral incisors, palatally dis- placed canines, and transpositions of various teeth. [2][3][4][5][6][7][8][9][10] Accumulated evidence on associations among this group go well beyond coincidence, suggesting them as part of a broader genetically related pattern of dental anomalies.…”

Section: Introductionmentioning

confidence: 99%

Malposition of Unerupted Mandibular Second Premolar in Children with Cleft Lip and Palate

Shalish

Will

Shustermann

2007

The Angle Orthodontist

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Objective: To determine whether distoangular malposition of the unerupted mandibular second premolar (MnP2) is more frequent in children with unilateral clefts of the lip and palate. Materials and Methods: This retrospective study examined panoramic radiographs from 45 patients with unilateral clefts of the lip and/or palate who had no previous orthodontics. A control sample consisted of age-and sex-matched patients. The distal angle formed between the long axis of MnP2 and the tangent to the inferior border was measured. The mean, standard deviation, and range were calculated for the angles measured in the cleft and the control groups. The significance of the differences between the means was evaluated by the paired t-test. The angles of the cleft and noncleft sides were also measured and compared. Results: The mean inclination of the MnP2 on the cleft side was 73.6Њ, compared with 84.6Њ in the control group. This difference was highly significant statistically (P Ͻ .0001). The difference in angles from the cleft and noncleft sides was 0.7Њ, not statistically significant. A significant association was found between clefting and distoangular malposition of the developing MnP2, suggesting a shared genetic etiology. This association is independent of the clefting side, ruling out possible local mechanical effects. Conclusion: Clinicians should be aware of the potential for anomalous development of MnP2 in children with clefts.

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Malposition of unerupted mandibular second premolar associated with agenesis of its antimere

Cited by 45 publications

References 12 publications

Pygmoid Australomelanesian Homo sapiens skeletal remains from Liang Bua, Flores: Population affinities and pathological abnormalities

Pygmoid Australomelanesian Homo sapiens skeletal remains from Liang Bua, Flores: Population affinities and pathological abnormalities

Malposition of Unerupted Mandibular Second Premolar in Children with Palatally Displaced Canines

Malposition of Unerupted Mandibular Second Premolar in Children with Cleft Lip and Palate

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