MALT1 positively correlates with Th1 cells, Th17 cells, and their secreted cytokines and also relates to disease risk, severity, and prognosis of acute ischemic stroke

Chen, Xia; Zhang, Xuemei; Ling, Lan; Xu, Guoyao; Li, Yanchun; Huang, Shaoming

doi:10.1002/jcla.23903

Cited by 16 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, up-regulated gga-miR-2954 at 10 DPI and down-regulated gga-miR-2954 at 15 DPI may be related to the expression of RARA, thus promoting the differentiation of Th1 or Th2 cells at 10 and 15 DPI, respectively [47] [48]. At 10 and 15 DPI, sustained down-regulation of gga-miR-7460-3p and gga-miR-145-5p may promote Th1 and Th17 differentiation by disinhibiting RIPK2 and MALT1, respectively [49] [50]. At 10 DPI, down-regulated gga-miR-214 may promote Th1/Th17 and inhibit Th2 through disinhibiting SOCS5, STAT3[51] [52].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profile of Chicken cecal in different stages during Histomonas meleagridis infection

Zhang

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Histomonas meleagridis is an anaerobic, intercellular parasite, which infects gallinaceous birds such as turkeys and chickens. In recent years, the reemergence of Histomoniasis has caused serious economic losses as drugs to treat the disease have been banned. At present, H. meleagridis research focuses on virulence, gene expression analysis, and the innate immunity of the host. However, there are no studies on the differentially expressed miRNAs (DEMs) associated with the host inflammatory and immune responses induced by H. meleagridis. In this research, high-throughput sequencing was used to analyze the expression profile of cecal miRNA at 10 and 15 days post-infection (DPI) in chickens infected with Chinese JSYZ-F strain H. meleagridis.Results: Compared with the controls, 94 and 127 DEMs were found in cecal of infected chickens at 10 DPI (CE vs CC) and 15 DPI (CEH vs CCH), respectively, of which 60 DEMs were shared at two-time points. Gene Ontology (GO) functional enrichment analysis of the target genes of DEMs indicated that 881 and 1027 GO terms were significantly enriched at 10 and 15 DPI, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the target genes of DEMs demonstrated that 5 and 3 KEGG pathways were significantly enriched at 10 and 15 DPI, respectively. The integrated analysis of miRNA–gene network revealed that the DEMs played important roles in the host inflammatory and immune responses to H. meleagridis infection by dynamically regulating expression levels of inflammation and immune-related cytokines. Conclusion: This article not only suggested that host miRNA expression was dynamically altered by H. meleagridis and host but also revealed differences in the regulation of T cell involved in host responses to different times H. meleagridis infection. This article contributes to future research into miRNA-target interactions during H. meleagridis infection in chickens and provides new ideas for H. meleagridis treatment and control.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profile of Chicken cecal in different stages during Histomonas meleagridis infection

Zhang

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, RARA, having been shown to be involved in the differentiation of Th1 or Th2 cells [ 52 , 58 ], was found to be potentially targeted by gga-miR-2954 that showed an up-regulated expression at 10 DPI and a down-regulated expression at 15 DPI. Moreover, PIPK2 [ 53 ], MALT1 [ 54 ], SOCS5 [ 50 ], STAT3 [ 51 ], IL12B [ 56 ], and IRF4 [ 57 ] has been shown to be associated with Th response. Among these, PIPK2 and MALT1 has been shown to be associated with promotion of Th1 and Th17 differentiation, respectively [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, PIPK2 [ 53 ], MALT1 [ 54 ], SOCS5 [ 50 ], STAT3 [ 51 ], IL12B [ 56 ], and IRF4 [ 57 ] has been shown to be associated with Th response. Among these, PIPK2 and MALT1 has been shown to be associated with promotion of Th1 and Th17 differentiation, respectively [ 53 , 54 ]. STAT3 was capable of inhibiting Th2-mediated immune responses [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profile of chicken cecum in different stages during Histomonas meleagridis infection

Zhang

Chen

et al. 2022

BMC Vet Res

View full text Add to dashboard Cite

Background Histomonas meleagridis is an anaerobic, intercellular parasite, which infects gallinaceous birds such as turkeys and chickens. In recent years, the reemergence of Histomoniasis has caused serious economic losses as drugs to treat the disease have been banned. At present, H. meleagridis research focuses on virulence, gene expression analysis, and the innate immunity of the host. However, there are no studies on the differentially expressed miRNAs (DEMs) associated with the host inflammatory and immune responses induced by H. meleagridis. In this research, high-throughput sequencing was used to analyze the expression profile of cecum miRNA at 10 and 15 days post-infection (DPI) in chickens infected with Chinese JSYZ-F strain H. meleagridis. Results Compared with the controls, 94 and 127 DEMs were found in cecum of infected chickens at 10 DPI (CE vs CC) and 15 DPI (CEH vs CCH), respectively, of which 60 DEMs were shared at two-time points. Gene Ontology (GO) functional enrichment analysis of the target genes of DEMs indicated that 881 and 1027 GO terms were significantly enriched at 10 and 15 DPI, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG, www.kegg.jp/kegg/kegg1.html) pathway enrichment analysis of the target genes of DEMs demonstrated that 5 and 3 KEGG pathways were significantly enriched at 10 and 15 DPI, respectively. For previous uses, the Kanehisa laboratory have happily provided permission. The integrated analysis of miRNA–gene network revealed that the DEMs played important roles in the host inflammatory and immune responses to H. meleagridis infection by dynamically regulating expression levels of inflammation and immune-related cytokines. Conclusion This article not only suggested that host miRNA expression was dynamically altered by H. meleagridis and host but also revealed differences in the regulation of T cell involved in host responses to different times H. meleagridis infection.

show abstract

“…Subsequently, qPCR was conducted using KOD SYBR ® qPCR Mix (Toyobo). The primers used in the current study were designed according to a previous study 19 . The relative expression of MALT1 was calculated by the 2 −ΔΔCt method with GAPDH as the internal reference 20…”

Section: Methodsmentioning

confidence: 99%

“…disease characteristics, mucosa-associated lymphoid tissue lymphoma translocation protein 1, rheumatoid arthritis, treatment response and remission, tumor necrosis factor inhibitors the current study were designed according to a previous study. 19 The relative expression of MALT1 was calculated by the 2 −ΔΔCt method with GAPDH as the internal reference. 20…”

Section: Introductionmentioning

confidence: 99%

Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 in rheumatoid arthritis: Longitudinal change after treatment and correlation with treatment efficacy of tumor necrosis factor inhibitors

Wang

Liu

Xiang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) correlates with treatment outcomes in inflammatory bowel disease and rheumatoid arthritis (RA). This study aimed to further evaluate the MALT1 longitudinal change and its relationship with tumor necrosis factor inhibitors (TNFi) response in RA patients. Methods Seventy‐one RA patients receiving TNFi [etanercept ( n = 42) or adalimumab ( n = 29)] were enrolled. MALT1 was detected by RT‐qPCR in peripheral blood samples of RA patients before treatment (W0), at week (W)4, W12, and W24 after treatment. RA patients were divided into response/non‐response, remission/non‐remission patients according to their treatment outcome at W24. Meanwhile, MALT1 was also detected by RT‐qPCR in 30 osteoarthritis patients and 30 healthy controls (HCs). Results Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 was elevated in RA patients compared with HCs ( Z =−6.392, p < 0.001) and osteoarthritis patients ( Z = −5.020, p < 0.001). In RA patients, MALT1 was positively correlated with C‐reactive protein ( r s = 0.347, p = 0.003), but not other clinical characteristics, treatment history, or current TNFi category. Meanwhile, MALT1 decreased from W0 to W12 in total RA patients ( x 2 = 86.455, p < 0.001), etanercept subgroup ( x 2 = 46.636, p < 0.001), and adalimumab subgroup ( x 2 = 41.291, p < 0.001). Moreover, MALT1 at W24 ( p = 0.012) was decreased in response patients compared with non‐response patients; MALT1 at W12 ( p = 0.027) and W24 ( p = 0.010) were reduced in remission patients than non‐remission patients. In etanercept subgroup, MALT1 at W24 ( p = 0.013) was decreased in response patients compared with non‐response patients. In adalimumab subgroup, MALT1 at W24 ( p = 0.015) was lower in remission patients than non‐remission patients. Conclusion Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 reduction after treatment is associated with response and remission to TNFi in RA patients.

show abstract

MALT1 positively correlates with Th1 cells, Th17 cells, and their secreted cytokines and also relates to disease risk, severity, and prognosis of acute ischemic stroke

Cited by 16 publications

References 23 publications

MicroRNA expression profile of Chicken cecal in different stages during Histomonas meleagridis infection

MicroRNA expression profile of Chicken cecal in different stages during Histomonas meleagridis infection

MicroRNA expression profile of chicken cecum in different stages during Histomonas meleagridis infection

Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 in rheumatoid arthritis: Longitudinal change after treatment and correlation with treatment efficacy of tumor necrosis factor inhibitors

Contact Info

Product

Resources

About