Mammalian GPI-anchor modifications and the enzymes involved

Liu, Yi-Shi; Fujita, Morihisa

doi:10.1042/bst20191142

Cited by 38 publications

(33 citation statements)

References 72 publications

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“…In the biosensor the interaction between the biological molecules take place that may be kid of enzyme and the receptors which is really dangerous for the health. The heavy metals which are highly stabilized make the complex of the metals cannot be recognized by the biological molecule are really harmed for the living organism and mostly bound are present [30,31].…”

Section: Fluorescence Basedmentioning

confidence: 99%

Review on Biochemical Detection of Biological, Plant Samples Using Integrative Approach

Hussain¹,

Ghafoor²,

Rauf³

et al. 2021

Scholars Bulletin

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Biosensor is the system which is generally consists of the system which recognizes the biological samples in appropriate manner. Bio receptor makes interaction with the analytic and transducer help in the amplification of the signals and measureable signals can be displayed on the screen in the form of the electrical signals. Bio-receptor is a biological molecule such as the enzyme, antibody, protein, and nucleic acid which is commonly present in the living organism which is used in the recognition of the biological molecule. Different techniques play as the key role in the technologies for the specificity, for seeking the measurement analyte make interaction with the electrode of the sensor. Biological signal based Biosensor can be categorized as Immuno-biosensor, Enzyme Based biosensor, Nucleic acid /DNA based biosensor and Cellular based biosensor. In the body with the high specificity and the sensitivity the ability of to detect the physiological and the pathogenic related molecules offers a opportunity which is very powerful and helpful in the treatment of the disease with the early diagnosis. The metals such nickel, cobalt which play essential role and act as the catalyst and also stabilize the structure of biological molecule such as the bacterial cell wall and the proteins. The metals in the high concentration cause the toxicity in the blood.

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Section: Fluorescence Basedmentioning

confidence: 99%

Review on Biochemical Detection of Biological, Plant Samples Using Integrative Approach

Hussain¹,

Ghafoor²,

Rauf³

et al. 2021

Scholars Bulletin

View full text Add to dashboard Cite

show abstract

“…Like in the case of the N- glycans, GSL glycans are generated and extended in the lumen of the ER and Golgi, leading to a topological distribution of GSL on the extracellular side of the plasma membrane [ 64 ]. Another lipid class that contains a glycan core are the glycosylphosphatidylinositol (GPI)-anchors [ 65 , 66 ]. Those are assembled on phosphatidylinositol moieties with the sequential addition of one Glc N Ac and four mannoses (Man), but also ethanolamine groups, in the ER lumen [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

Glycans in autophagy, endocytosis and lysosomal functions

et al. 2021

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Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

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“…The conserved GPI moiety is composed of ethanolamine phosphate (EtNP), a conserved core glycan and phosphatidylinositol. The core glycan consists of three mannoses (Man) and one glucosamine (GlcN) residue that are linked to EtNP and phosphatidylinositol forming the GPI backbone structure EtNP-6Manα1-2Manα1-6Manα1-4GlcNα1-6myo-inositol-phospholipid (Kinoshita and Fujita, 2016;Liu and Fujita, 2020; Figure 1). Proteins destined to be GPI-anchored are translocated into the lumen of the endoplasmic reticulum (ER), the GPI attachment signal peptide at the C-terminus is cleaved off and the preassembled GPI is transferred en bloc to the last amino acid of the C-terminus called the ω site.…”

Section: Introductionmentioning

confidence: 99%

Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective

et al. 2020

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More than 200 diverse secretory proteins from Arabidopsis thaliana carry a glycosylphosphatidylinositol (GPI) lipid anchor covalently attached to their carboxyl-terminus. The GPI-anchor contains a lipid-linked glycan backbone that is preassembled in the endoplasmic reticulum (ER) of plants and subsequently transferred to distinct proteins, which provides them with specific features. The GPI-anchored proteins exit the ER and are transported through the Golgi apparatus to the plasma membrane. In the Golgi, the glycan moiety can be further modified by the specific attachment of sugar residues. While these biosynthetic steps are already quite well understood in mammals and yeast, comparatively little is known in plants. In this perspective, we discuss the current knowledge about the biosynthesis of the GPI-anchor glycan moiety in the light of recent findings for mammalian GPI-anchor glycan modifications.

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Mammalian GPI-anchor modifications and the enzymes involved

Cited by 38 publications

References 72 publications

Review on Biochemical Detection of Biological, Plant Samples Using Integrative Approach

Review on Biochemical Detection of Biological, Plant Samples Using Integrative Approach

Glycans in autophagy, endocytosis and lysosomal functions

Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective

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