Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog

Marinelli, Lieta; Gabai, Gianfranco; Wolfswinkel, Josien C. van; Mol, Jan A.

doi:10.1016/j.jsbmb.2004.08.001

Cited by 18 publications

(21 citation statements)

References 50 publications

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“…The effects of obesity on the development, progression, and prognosis of breast or mammary tumors are primarily related to the accumulation of excessive adipose tissue and secretion of mammary gland growth factors such as estrogens and leptin. Overexposure of the mammary tissues to growth factors, particularly estrogens, may cause the development of mammary tumors in humans and dogs (Clemons and Goss, 2001;Marinelli et al, 2004). Obesity increases the risk of breast cancer in post-menopausal women and promotes the development of cancers with aggressive phenotypes (Carmichael, 2006).…”

Section: Discussionmentioning

confidence: 99%

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Lim

Kim

et al. 2015

The Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Lim

Kim

et al. 2015

The Veterinary Journal

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“…Oestradiol is supposed to have a mitogenic effect on CMT (Queiroga et al. 2008) and could derive from early tumour stages (Marinelli et al. 2004) possibly acting as an autocrine growth stimulant.…”

Section: Discussionmentioning

confidence: 99%

“…Another interesting finding was a higher oestradiol concentration in bitches with tumours of TNM stage 1 than those at stage 3. Oestradiol is supposed to have a mitogenic effect on CMT (Queiroga et al 2008) and could derive from early tumour stages (Marinelli et al 2004) possibly acting as an autocrine growth stimulant. But, the influence of the oestrous cycle and hormonal treatment on this difference of oestradiol concentration has to be determined in further studies.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Local Expression of the Relaxin System in Canine Mammary Tumours

Lamp

Honscha

Jakob³

et al. 2009

Reprod Domestic Animals

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While mammary tumours are the main reasons of death in bitches, early detection of tumours and metastases is crucial for survival of affected dogs. Invasiveness and angiogenesis, which are important processes of tumour growth and spreading, require connective tissue remodelling. This process is dominantly mediated by matrix metalloproteinases (MMP), which are well known to be positively regulated by relaxin (RLX) in various tissues, including human breast cancer. So far, the presence of RLX and its receptor RXFP-1 as well as their linkage with MMP in canine mammary tumours (CMT) is completely unknown. In the first part of the present study, concentrations of RLX, oestradiol and progesterone from plasma samples of bitches with CMT were compared with clinical and survival data to investigate the predictive value of these hormones. In the second part, the expressions of RLX, RXFP-1 and MMP-2, -9 and -13 were examined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in 31 CMT samples. Finally, relationships of systemic plasma RLX or locally expressed RLX with expression of MMP in CMT were analyzed for the first time. Comparison of hormone concentrations in 93 bitches in terms of benign or malignant nature of the CMT, lung metastases, recidivation and 12-month survival discovered no significances. The expressions of RLX, RXFP-1 and MMP were independent from plasma RLX, but expressions of local RLX and RXFP-1 showed a strong correlation (p = 0.00004, r = 0.671) as well as RXFP-1 and MMP-2 (p = 0.009, r = 0.463), indicating a possible significant role of the locally produced RLX in CMT pathogenesis as an inducer of connective tissue remodelling.

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“…An agreement is that the occurrence of mammary hyperplasia is related to endocrine disorders (Henry, 2014). On one hand, estrogen is believed to participate in the proliferation of mammary gland via stimulating the growth and proliferation of mammary cells, on the other hand, estrogen can generate considerable reactive oxygen species (ROS) and lead to high level of oxidative stress (Das Gupta et al, 2014;Marinelli et al, 2004). Oxidative stress will alter the immune system and plays a crucial role in estrogen-induced HMG and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Anti-hyperplasia effects of Rosa rugosa polyphenols in rats with hyperplasia of mammary gland

Chen

et al. 2015

Environmental Toxicology and Pharmacology

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Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog

Cited by 18 publications

References 50 publications

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Investigation of the Local Expression of the Relaxin System in Canine Mammary Tumours

Anti-hyperplasia effects of Rosa rugosa polyphenols in rats with hyperplasia of mammary gland

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