Mammary Tumors With Sebaceous Differentiation in Dogs

Grandi, Fabrizio; Salgado, Breno S.; Cassali, G. D.; Rocha, Noeme Sousa

doi:10.1177/0300985811398253

Vet Pathol

2011

DOI: 10.1177/0300985811398253

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Mammary Tumors With Sebaceous Differentiation in Dogs

Fabrizio Grandi

Breno S. Salgado

G. D. Cassali

et al.

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2013

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“…Thus, the new system could be helpful to diagnose benign canine mammary tumors on the basis of their histology and cell origin. However, a few reported atypical adenomas could not be classified using this system [5,9,16]. This paper shows a rare case of canine mammary adenoma with proliferating cystic ducts comprising a single layer of basaloid cells with myoepithelial differentiation.…”

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Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation

et al. 2013

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ABSTRACT. This report describes an atypical mammary adenoma with a rare histological feature characterized by proliferating single-layered cystic ducts composed of basaloid cells with frequent myoepithelial differentiation. A 9-year-old, intact female Miniature Pinscher dog had mammary tumors on the thorax. Histologically, one of tumors comprised the proliferation of two types of tubular structures; the singlelayered cystic ducts lined by flattened cells and double-layered tubules with luminal cells and outer spindle cells. The former ducts were predominant in the tumor and contained pale basophilic mucus, which was Alcian blue (pH 2.5)-positive, but periodic acid Schiff-negative. Immunohistochemical staining indicated that the cells lining single-layered cystic ducts were negative for the luminal epithelial marker, cytokeratin (CK) CAM5.2, but were constantly positive for basal cell markers CK14 and p63 and frequently positive for SMA. Electron microscopy revealed fine, parallel myofilaments within these single-layered neoplastic cells. These histological and immunohistological examinations suggested that the origin of the tumor was bipotential mammary progenitor cells with predominant differentiation into the myoepithelial progenitor linage.

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Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation

et al. 2013

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Mammary Tumors With Sebaceous Differentiation in Dogs

Cited by 1 publication

References 7 publications

Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation

Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation

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