Mammographic Breast Density Patterns in Asymptomatic Mexican Women

Calderón-Garcidueñas, Ana Laura; Sanabria-Mondragón, Mónica; Hernández-Beltrán, Lourdes; López-Amador, Noé; Cerda‐Flores, Ricardo M.

doi:10.1155/2012/127485

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…In Mexico, BC is a public health problem because it is the main cause of death by malignant tumours in women of reproductive age [ 1 ]. In this study, we observed that BC was often detected before of 50 years of age, similar to what has been reported by other authors in the Mexican population [ 15 , 16 ]. This observation confirms that this pathology is detected in Mexican women a decade before the normal age of onset in other countries [ 17 , 18 ].…”

Section: Discussionsupporting

confidence: 92%

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

Pérez-Rodríguez¹,

Aranda-Moreno²,

Olivares-Corichi³

et al. 2015

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Aim of the studyIn breast cancer, oestrogen receptor (ER), progesterone receptor (PgR), and HER2 (HER2/Neu) expression status are used to classify neoplasms into subtypes: Luminal A, Luminal B, HER2/Neu type, and Basallike. The aim of the present study was to establish the molecular subtypes of breast cancers and their association with tumour characteristics and reproductive factors in Mexican women.Material and methodsA total of 1326 biopsies of breast tumour tissues were analysed for ER, PR, and HER2/Neu by immunohistochemistry (IHC). Information regarding age, tumour characteristics, and node involvement profiles were collected.ResultsIHC established that the most common subtype of breast cancer was Luminal A (64.93%), followed by Basal-Like (13.88%), Luminal B (12.52%), and HER2/Neu (8.67%). T2-size tumours (> 2 cm but < 5 cm) were present in 47.59% of all patients. Univariate analysis showed that lymph node positivity (p = 0.009), stage (p = 0.013), and placement of the tumour (p = 0.001) were factors associated with breast cancer subtype.ConclusionsOur data show that IHC is useful for distinguishing different subtypes of breast cancer and that Luminal A is the most common breast cancer subtype in the Mexican population. All subtypes were associated with unfavourable clinicopathological features, suggesting that late diagnosis is an important contributor to high mortality rates in the Mexican population.

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Section: Discussionsupporting

confidence: 92%

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

Pérez-Rodríguez¹,

Aranda-Moreno²,

Olivares-Corichi³

et al. 2015

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“…Screening US in women with dense breasts and negative MG can yield an incremental increase in the cancer detection rate of 3.7 to 4.2 more cancers identified per 1000 women screened. [ 6 , 7 , 15 ] Asian women, compared with Western women, more often have small, dense breasts, [ 16 ] and US is an appropriate tool for breast cancer detection in these women. [ 17 ] In our study, 421 (88.6%) small cancers were detected by US, which was higher than MG, and we demonstrated that US was significantly better than MG at detecting malignancy in patients with high breast density.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the sensitivity of mammography, ultrasound, magnetic resonance imaging and combinations of these imaging modalities for the detection of small (≤2 cm) breast cancer

et al. 2021

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The aim of this study was to compare the sensitivity of mammography (MG), ultrasound (US), magnetic resonance imaging (MRI), and combinations of these imaging modalities for the detection of small (≤2 cm) breast cancer and to evaluate the benefit of preoperative breast MRI after performing conventional imaging techniques for small breast cancer. This was an observational retrospective review of 475 patients with pathologically confirmed breast cancer. We reviewed the medical records; assessed the preoperative reports of MG, US, and MRI; and categorized them as benign features (BI-RADS 1–3) or malignant features (BI-RADS 4 or 5). The criterion standard for detection was the pathologic assessment of the surgical specimen. The sensitivities of the different techniques were compared using the McNemar test. Among the 475 women, the sensitivity of MG was significantly greater in patients with low breast density than in those with high breast density (84.5% vs 65.8%, P < .001). US had higher sensitivity than MG ( P < .001), and the combination of MG + US showed better sensitivity than MG or US alone ( P < .001). Further addition of MRI to the combination of MG and US statistically contributed to the sensitivity yield (from 93.3% to 98.2%; P < .001) but did not significantly increase the mastectomy rate (from 48.2% to 49.3%; P = .177). MG has limited diagnostic sensitivity in patients with small breast cancer, especially in those with dense breast tissue. US is better than MG at detecting small breast cancer, regardless of breast density. The addition of MRI to MG and US could increase sensitivity without increasing the mastectomy rate. This study suggests performing MRI routinely on the basis of MG and US for small (≤2 cm) breast cancer.

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“…[24252627] However, some factors such as obesity could modify this because of the inverse relationship between body mass index and mammographic density. [272829] There are conflicting reports, with some reporting an association between breast density pattern and menopausal status, while another demonstrated contrasting results. [21830]…”

Section: Discussionmentioning

confidence: 99%

Mammographic parenchymal patterns in asymptomatic women

Akande

Olafimihan

Oyinloye

2017

Saudi J Med Med Sci

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Background:Breast density has been found to be an independent risk factor for breast cancer. Mammographic breast parenchymal pattern or percent density is mainly a reflection of the proportion of glandular tissue to fatty tissue, and studies have shown that it works synergistically with other risk factors such as nulliparity in predicting breast cancer risk. This study analyses the various mammographic breast patterns and correlates this with some demographic variables and final Breast Imaging Reporting and Data System outcomes of asymptomatic women in our center.Materials and Methods:This is a prospective descriptive study of mammographic breast pattern in 459 females who presented at the breast imaging suite of our institution. Mammography was performed after completion of an assisted administered questionnaire for demographic information. A GE Senographe DMR machine using two standard views (craniocaudal and mediolateral oblique) and additional views were used when necessary.Results:A total of 459 women ranging in age from 34 to 80 years were included in the study, of which 46.6% were in the age range of 41 to 50 years. The scattered fibroglandular pattern was the most common pattern found (44%), and the homogeneous dense pattern was the least common (0.4%). A significant association with age and menopause status was found, while no association was found with age at the time of the woman's first delivery and family history of breast cancer.Conclusion:This study demonstrates that there is a significant association between breast cancer and age and menopause status. However, no correlation was found with the age of women at their first delivery and family history of breast cancer.

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Mammographic Breast Density Patterns in Asymptomatic Mexican Women

Cited by 6 publications

References 18 publications

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

Comparison of the sensitivity of mammography, ultrasound, magnetic resonance imaging and combinations of these imaging modalities for the detection of small (≤2 cm) breast cancer

Mammographic parenchymal patterns in asymptomatic women

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