The use of manufacturing system reconfiguration in conjunction with maintenance operations has not been previously reported in the literature. This research attempts to incorporate reconfiguration into Preventive Maintenance (PM) actions for improved system performance in terms of reduced total cost. This paper presents an Integrated Reconfiguration and Age-Based Maintenance (IRABM) policy and applies it to a parallel-serial manufacturing system. The expected total cost of implementing the IRABM policy is estimated and minimized through a simulation-based heuristic optimization procedure. Using this method, it is possible to systematically identify the conditions under which the integration of reconfiguration into maintenance is cost effective. In addition, numerical examples demonstrate that the manufacturing system could have a higher probability of fulfilling production requirements at a lower cost under the IRABM policy compared to the conventional age-based PM policy. The influences of the input parameters associated with reconfiguration, production, and reliability on the performance of IRABM policy also are studied.