Management and follow-up of differentiated thyroid cancer not submitted to radioiodine treatment: a systematic review

Gambale, Carla; Elisei, Rossella; Matrone, Antonio

doi:10.23736/s0391-1977.20.03240-x

Cited by 7 publications

(7 citation statements)

References 87 publications

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“…Nonetheless, the surgical method must be chosen with care, considering the influence on the quality of life and the development of growing pediatric patients [23]. Moreover, surgical treatment has been shifting toward a conservative approach in patients with low and intermediate risk differentiated thyroid cancer in recent years [24]. Over the last decade, robotic surgical systems have provided surgeons with a three-dimensional working field, a magnified view, a tremor-filtering system, and multiarticulated instruments.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Lee

Kim

et al. 2021

Cancers

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Thyroid cancer in children is very uncommon. For pediatric thyroid cancer, robotic surgery has served as a minimally invasive surgical alternative to conventional open surgery. Our study aimed to evaluate the results of robotic versus open surgical treatment for patients with thyroid cancer younger than 20 years of age at the time of diagnosis. This retrospective review included 161 pediatric patients who underwent robotic transaxillary or conventional open thyroidectomy at our institution from 2008 to 2019. Of these patients, 99 comprised the robotic group and 62 the open group. Patient demographics, surgical outcomes, and disease-free survival rates were compared between the two groups. Patients in the open group were more likely to have advanced stage diseases with a larger tumor size and higher tumor-node-metastasis stage than those in the robotic group. Operation time and follow-up period were similar in both groups. Patients in the robotic group had a lower rate of postoperative complications and a shorter length of hospital stay, but they also had a lower average number of retrieved central lymph nodes. However, there were no significant between group differences in recurrence rates and disease-free survival. In the hands of an experienced surgeon, robotic thyroidectomy is a feasible and safe option for pediatric patients.

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Section: Discussionmentioning

confidence: 99%

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Lee

Kim

et al. 2021

Cancers

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“…It was recently suggested that in low- or intermediate-risk DTC, lobectomy or total thyroidectomy seem sufficient treatment and the usefulness of radioiodine is being questioned [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Snail-1 in Thyroid Cancer—What We Know So Far

Wieczorek-Szukała

Lewiński

2021

JCM

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Thyroid carcinomas, despite the usually indolent behaviour and relatively good overall prognosis, show a high tendency to gain invasive phenotype and metastasise in some cases. However, due to a relatively slow progression, the exact mechanisms governing the metastatic process of thyroid carcinomas, including the epithelial-to-mesenchymal transition (EMT), are poorly described. One of the best-known regulators of cancer invasiveness is Snail-1—a zinc-finger transcription factor that plays a key role as an EMT inducer. More and more attention is being paid to the role of Snail with regard to thyroid cancer development. Apart from the obvious implications in the EMT process, Snail-1 plays an important role in the regulation of chemoresistance of the thyroid cells and cancer stem cell (CSC) formation, and it also interacts with miRNA specific to the thyroid gland. The aim of this review was to summarise the knowledge on Snail-1, especially in the context of thyroid oncogenesis.

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“…Therefore, it is necessary to find other more efficient diagnostic methods. In recent years, it has been found that thyroglobulin (Tg), interferon-γ (IFN-γ), thyroglobulin antibody, TgAb plays an important role in the occurrence and development of thyroid diseases (8,9). However, few studies have explored its role in the progression of TA, which is worthy of further study.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma

Min

Xiaxing

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to explore the value of combined detection of serum thyroglobulin (Tg), interferon - γ (IFN - γ) and thyroglobulin antibody (TgAb) in the diagnosis and prognosis of thyroid adenoma (TA). For this purpose, 100 patients with TA in our hospital from January 2017 to December 2020 were selected as the observation group, and they were divided into good prognosis group (83 cases) and poor prognosis group (17 cases) according to the surgical treatment; another 50 healthy people who received physical examination in our hospital. The levels of serum Tg, IFN - γ and TgAb in each group were detected and compared; the diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma were analyzed. Results showed that compared with the control group, the levels of Tg and TgAb in the observation group were significantly increased, and the levels of IFN - γ were significantly decreased (P < 0.05); compared with the poor prognosis group, the levels of Tg and TgAb in the good prognosis group were significantly decreased, and the levels of IFN - γ were significantly increased (P < 0.05); The area under curve (AUC) of the combined detection of serum Tg, IFN-γ and TgAb for TA diagnosis and prognosis assessment was significantly higher than the value detected by a single indicator. In general, the combined detection of serum Tg, IFN - γ and TgAb has high diagnostic and prognostic value for TA, and has high clinical reference value.

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Management and follow-up of differentiated thyroid cancer not submitted to radioiodine treatment: a systematic review

Cited by 7 publications

References 87 publications

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

The Role of Snail-1 in Thyroid Cancer—What We Know So Far

Diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma

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