Management and results of localized Ewing's sarcoma

Chan, Rafael C.; Sutow, Wataru W.; Lindberg, Robert D.; Samuels, Melvin L.; Murray, John A.; Johnston, Dennis A.

doi:10.1016/0360-3016(78)90647-8

Cited by 8 publications

(10 citation statements)

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“…Fully aware of the adverse effect on the survival curve, the last clinic visit dates of these patients with systemic metastases were computed as their dates of death. The five-year survival rate of the patients without metastases at diagnosis was 47.5%, not different from that reported by several investigators, 6,17 but lower than that described by others. 5,7,12 The factors contributing to low long-term survival rate in our patients included advanced stage of tumor at diagnosis and shorter duration of chemotherapy (median 8 months) because of lack of compliance, instead of 18 months of therapy administered by other institutions.…”

Section: Discussionmentioning

confidence: 46%

“…8,.11 Since a fair number of patients with localized Ewing's sarcoma develop systemic metastases despite local therapy, such as surgical resection or radiotherapy, chemotherapy was used in conjunction with radiotherapy with the hope of improving the long-term survival of these patients. 4,6,7,12,13 This multimodality treatment took advantage of the additive therapeutic effect of chemotherapy and radiotherapy on the tumor, while their adverse side effects on the normal tissues remained essentially unchanged. This study is a review of the experience in the therapy of Ewing's sarcoma at King Faisal Specialist Hospital and Research Centre (KFSH&RC).…”

Section: Introductionmentioning

confidence: 99%

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Therapy for Ewing’s Sarcoma: King Faisal Specialist Hospital and Research Centre Experience

et al. 1987

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Forty-one patients with histologically confirmed diagnosis of Ewing's sarcoma were treated between the years 1976 and 1983. Thirty patients without metastasis at diagnosis were treated with a combined regimen including radiotherapy to the primary tumor site and chemotherapy including cyclophosphamide, vincristine, actinomycin D and/or adriamycin. Eighteen of the thirty patients subsequently developed either local progression or systemic metastases. The median duration of relapse-free intervals was twenty months. Eight patients had local regrowth of primary tumor. Six of these eight patients subsequently developed systemic metastasis on the average six months after local progression. The five-year survival rate of the patients without metastases at diagnosis was 47.5%. Eleven patients with metastases at diagnosis were frequently found to have lung and bone involvement. These were the most common sites of tumor metastases in patients receiving therapy as well. The median duration of survival from time of systemic metastases was about 12 months. Long-term survivors were rare in this group, indicating the need for early diagnosis and intensive therapy to achieve control of the primary tumor and long-term, recurrence-free

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Section: Discussionmentioning

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Therapy for Ewing’s Sarcoma: King Faisal Specialist Hospital and Research Centre Experience

et al. 1987

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“…More recent series show a survival rate in patients with localized ES varying between 40% and 80% [7, 32-371. Radiotherapy as sole local treatment caused a high local failure rate ( 13-50%) and frequently secondary, radiation-induced malignancies (5 %), especially osteosarcoma and malignant fibrous histiocytoma. Because both complications may occur more than 10 years after treatment, the real frequencies are still unknown [38,39]. Patients with a local recurrence after radiotherapy or chemotherapy have the same bad prognosis as patients with metastatic disease, probably because tumor cell lines re-small tumors with good response to chemotherapy, where surgery would be insufficient (e.g., ES of the spine) or would bring intolerable mutilation or morbidity [36,37].…”

Section: Discussionmentioning

confidence: 99%

Ewing's sarcoma of bone: Oncologic and functional results

Renard

Veth

Pruszczyński

et al. 1995

Journal of Surgical Oncology

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This paper describes 29 patients with Ewing's sarcoma of bone treated between 1975 and 1990 at the University of Nijmegen Hospital, Nijmegen, The Netherlands. Osteomyelitis was the primary diagnosis in 24%. Treatment consisted of chemotherapy in combination with surgery and/or radiotherapy. Nine patients received radiotherapy only; five of them died of disease. Five patients underwent an intralesional excision; four of them died of disease. Twelve patients underwent a wide excision; there is no evidence of disease in any of them. Three patients underwent a radical disarticulation; all died of disease. The disease-free survival at 1.5 years was 66%. This figure at 5 years was 55%. After wide excision and reconstruction in tumors of expendable, femoral or radial bones good functional results were obtained in all cases.

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“…Anderson Hospital, four developed osteogenic sarcoma [17]. One had been treated with megavoltage radiotherapy alone, while the other three had all received chemotherapy with cyclophosphamide and vincristine in addition to megavoltage radiotherapy.…”

Section: Scussl Onmentioning

confidence: 99%

Osteogenic sarcoma following treatment with megavoltage radiation and chemotherapy for bone tumors in children

Freeman

Gledhill

Chevalier

et al. 1980

Med. Pediatr. Oncol.

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While osteogenic sarcoma has been well-recognized as a late complication of exposure to high doses of ionizing radiation in the orthovoltage energy range, it has been less frequently reported in patients treated with megavoltage radiation. This potential complication should, however, not be dismissed as an occurrence to be seen only after high-dose orthovoltage radiation. We have recently seen two children who developed osteogenic sarcoma following treatment with megavoltage radiation and combination chemotherapy for primary bone tumors. The implications in regard to aggressive multimodality treatment for pediatric malignancies are discussed.

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Management and results of localized Ewing's sarcoma

Cited by 8 publications

References 1 publication

Therapy for Ewing’s Sarcoma: King Faisal Specialist Hospital and Research Centre Experience

Therapy for Ewing’s Sarcoma: King Faisal Specialist Hospital and Research Centre Experience

Ewing's sarcoma of bone: Oncologic and functional results

Osteogenic sarcoma following treatment with megavoltage radiation and chemotherapy for bone tumors in children

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