Osteogenic sarcoma following treatment with megavoltage radiation and chemotherapy for bone tumors in children

Freeman, Carolyn R.; Gledhill, Robert B.; Chevalier, Louise; Whitehead, V. Michael; Esseltine, D. W.

doi:10.1002/mpo.2950080409

Cited by 13 publications

(3 citation statements)

References 17 publications

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“…Freeman et al [16] discussed three distinct criteria to be fulfilled before radiation could be linked to the development of secondary sarcoma. First, the second tumor should be of a distinct histologic type than the first tumor to rule out the possibility of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Sequential Ewing's sarcoma and osteosarcoma

Sharma

Crawford²,

Evans³

et al. 2008

Journal of Pediatric Orthopaedics B

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The sequential occurrence of two primary bone tumors, Ewing's sarcoma and osteosarcoma in the same patient at two different anatomical sites 5 years apart is rare. We report a case of 12-year-old boy who after treatment for Ewing's sarcoma of proximal fibula subsequently presented, 4 years later, with a high-grade fibroblastic osteosarcoma of the proximal humerus. The patient was also found to have a rare gene tranlocation t (7;22) instead of the more common t (11;22).

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Section: Discussionmentioning

confidence: 99%

Sequential Ewing's sarcoma and osteosarcoma

Sharma

Crawford²,

Evans³

et al. 2008

Journal of Pediatric Orthopaedics B

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“…Post-irradiation bone sarcoma represents one of the most frequent second malignant neoplasms in childhood cancer survivors. In the literature several papers deal with epidemiological, pathological and radiological findings [8,[21][22][23][24][25][26], with scanty information available on therapeutic strategies.…”

Section: Discussionmentioning

confidence: 99%

Treatment of childhood post-irradiation sarcoma of bone in cancer survivors

Cefalo¹,

Ferrari²,

Tesoro-Tess³

et al. 1997

Med. Pediatr. Oncol.

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Patients and Methods This is a retrospective review of five children with post‐irradiation bone sarcoma (PIS). Age at PIS onset ranged between 10 and 17 years (median 11). They were treated with a chemotherapy regimen, similar to that in use for primary osteogenic sarcoma, consisting of vincristine and high‐dose methotrexate alternated with cisplatinum and ifosfamide, given for 12 months. Results In all children chemotherapy induced a complete clinical remission. Four of them were alive in continuous complete remission at 1, 2, 4, and 12 years from the diagnosis of bone sarcoma. One girl recurred 3 years from PIS diagnosis and was salvaged by repeating the same chemotherapy program: she remained alive in second complete remission 8 years from relapse. Conclusions In spite of an intensive treatment previously given for the primary tumor, this drug schedule proved to be feasible and short‐term side effects were manageable. Chemotherapy alone, using an intensive regimen effective for primary osteogenic sarcoma, may be an adequate therapy for childhood post‐irradiation sarcoma. Med. Pediatr. Oncol. 29:568–572, 1997. © 1997 Wiley‐Liss, Inc.

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“…Second malignancies after orthovoltage radiation are well documented but are less frequently reported after megavoltage radiation [33]. Haselow et al [27] published the first review of 88 long-term survivors (mean 14 years) after megavoltage radiation and found one patient with a malignancy in the radiation field.…”

Section: Discussionmentioning

confidence: 99%