Management of a Chest-Wall Soft-Tissue Tumor Caused by an Infection with the Larval Tapeworm Pathogen Taenia crassiceps

Roesel, Christian; Welter, Stefan; Stamatis, Georgios; Theegarten, Dirk; Tappe, Dennis

doi:10.4269/ajtmh.14-0185

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…However, when its role in cancer was evaluated in a mice model study after methyl-nitrosourea exposure, only 35% of infected mice developed lymphoma, in contrast with 50% of control non-infected animals (Ordoñez et al, 2003), thus ruling out any association. However, surprisingly, recently, there was a report of presence of this parasite in soft tissue tumor (Roesel et al, 2014) in an immunocompetent patient. As this infection happens only with immunosuppressed individual, this new report draws the need of a detailed study about its role in cancer with modern tools.…”

Section: Cestodes and Nematodesmentioning

confidence: 99%

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Arora

Kaur

Anjum

et al. 2019

Front. Cell. Infect. Microbiol.

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Helminthic parasitic infection is grossly prevalent across the globe and is considered a significant factor in human cancer occurrence induced by biological agents. Although only three helminths (Schistosoma haematobium, Clonorchis sinensis, and Opisthorchis viverrini) so far have been directly associated with carcinogenesis; there are evidence suggesting the involvement of other species too. Broadly, human helminthiasis can cause chronic inflammation, genetic instability, and host immune modulation by affecting inter- and intracellular communications, disruption of proliferation–anti-proliferation pathways, and stimulation of malignant stem cell progeny. These changes ultimately lead to tumor development through the secretion of soluble factors that interact with host cells. However, the detailed mechanisms by which helminths introduce and promote malignant transformation of host cells are still not clear. Here, we reviewed the current understanding of immune-pathogenesis of helminth parasites, which have been associated with carcinogenesis, and how these infections initiate carcinogenesis in the host.

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Section: Cestodes and Nematodesmentioning

confidence: 99%

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Arora

Kaur

Anjum

et al. 2019

Front. Cell. Infect. Microbiol.

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“…Excreted eggs of T. crassiceps may cause cysticercosis, especially in individuals with weakened immunity, and endanger the health of not only animals but also humans [23,29]. For this reason the owners could underestimate risk of zoonosis and the risk of parasitosis should be suppressed by regular laboratory tests and corresponding therapy.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Occurrence of Gastrointestinal Parasites and Lungworms in Dogs and Assessment of Antiparasitic Drugs use Patterns

Vernerová¹,

Dvorakova²,

Svobodová³

et al. 2020

Preprint

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Background Endoparasites of the canine gastrointestinal and respiratory tract represent a wide range of protozoans and helminths. They are causative agents of different serious diseases of animals and many of them also pose zoonotic risks to human health. The education of dog owners and their families with the principles of human and animal health protection may especially prevent the spread of zoonoses such giardiosis, toxocarosis, echinococcosis and Taenia crassiceps infection. Pulmonary nematods are not zoonotic but they can cause serious and potentially fatal disease in dogs.MethodsThree hundred ninety-one samples of canine faeces and 398 completed questionnaires were collected. The questionnaires comprised of description of individual dogs and detailed data about the way the dogs were kept and their deworming. Samples were examined by flotation, larvoscopy by Baermann and PCR method.ResultsWe confirmed infection of Giardia spp., Isospora ohioensis, Neospora caninum/Hammondia heydorni, Ancylostoma spp., Angiostrongylus vasorum, Capillaria spp., Crenosoma vulpis, Toxocara canis, Toxascaris leonina, Trichuris spp. and Taenia spp. Sequences were obtained for 3 of them confirming T. crassiceps. No deworming treatment was recorded for insignificant number of dogs. Dog owners most often used multicomponent endoparasitics.ConclusionsMost of the dogs were dewormed irregularly and antiparasitics were administered namely twice a year, so monthly intervals were not performed in the group of dogs at risk for e.g. possibility of predation. Consumption of antiparasitic drugs cannot ensure the protection of dogs, their owners and other people, unless not applied purposefully, with appropriate knowledge and on the basis of the veterinarian's advice.

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“…Among animals, fatal cases of T. crassiceps cysticercosis were described in, e.g., a ring-tailed lemur (Lemur catta) from Madrid Zoo in Spain (Luzon et al 2010), in a chinchilla (Chinchilla laniger) from Switzerland (Basso et al 2014), in a wild red fox (Vulpes vulpes) in Croatia (Konjevic et al 2016) and the subcutaneous form doi: 10.17221/82/2017-VETMED in a dog in Germany (Nolte et al 2016). As for recent human infections, e.g., two cases in immunocompetent patients in Germany were described (Ntoukas et al 2013;Roesel et al 2014); further, cysticercosis was described in a HIV-positive woman from Switzerland who worked as an employee in a zoo (Anikpeh et al 2014). …”

Section: Discussionmentioning

confidence: 99%

Unusual cases of Taenia crassiceps cysticercosis in naturally infected animals in the Czech Republic

Hofmannová¹,

Mikeš²,

Jedlickova³

et al. 2018

Vet. Med.

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ABSTRACT:The tapeworm Taenia crassiceps has an indirect life cycle. Occasionally, metacestode stages have been reported from aberrant hosts as dogs, cats, lemurs and humans. This study describes an unusual series of serious cysticercosis cases: an 18-month-old male Yorkshire terrier dog with pleural cysticercosis accompanied by a cough, a 10-year-old male Shih Tzu dog with subcutaneous cysticercosis as well as a Cape ground squirrel and a Senegal bushbaby, both with generalised cysticercosis. Surgery was successful only in the Shih Tzu. The Yorkshire terrier died a few hours after surgery, while the Cape ground squirrel was euthanised and the Senegal bushbaby died before surgery. Cysticerci from the four cases were identified morphologically and using molecular methods. Fragments of genes coding for cytochrome oxidase subunit 1 were sequenced for each of the four isolates. Their affiliation to T. crassiceps was confirmed by comparison with the sequence data of other isolates available in the GenBank database. In general, the comparison of sequences of all isolates showed low variability in nucleotide composition (at most five positions). The cases from captive zoo animals represent the first findings of T. crassiceps in the Cape ground squirrel and Senegal bushbaby. The optimal treatment of cysticercosis caused by T. crassiceps remains unclear. Successful attempts usually include extensive surgical interventions and prolonged anthelmintic treatment. Chemotherapeutic options are limited. Although regular deworming targeting intestinal helminths of dogs is not effective against T. crassiceps cysticerci, it may help to prevent contamination of the environment by tapeworm eggs contained in dog faeces and reduce the risk of infection for susceptible animals and humans.

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Management of a Chest-Wall Soft-Tissue Tumor Caused by an Infection with the Larval Tapeworm Pathogen Taenia crassiceps

Cited by 10 publications

References 15 publications

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Factors Affecting the Occurrence of Gastrointestinal Parasites and Lungworms in Dogs and Assessment of Antiparasitic Drugs use Patterns

Unusual cases of Taenia crassiceps cysticercosis in naturally infected animals in the Czech Republic

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