2017
DOI: 10.1016/j.afjem.2017.09.003
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Management of acute seizures in children: A review with special consideration of care in resource-limited settings

Abstract: IntroductionWe sought to review recent evidence-based guidelines and where applicable, primary data to extrapolate insights into the appropriate management of acute seizures in children in resource-limited settings.MethodsPubMed and Google scholar searches were conducted with attention to publications from the last three to five years, including a focused search for acute seizure management guidelines relevant to resource limited settings. Since all guidelines to date, except the World Health Organization’s, a… Show more

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Cited by 12 publications
(10 citation statements)
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“…According to the literature, apart from specific situations (state of illness, underlying etiology with high potential for recurrence), it is not reasonable to offer long-term treatment [15]. Obviously, optimal management depends on the etiology and severity of the attack [7]. Hospitalization mainly concerned patients with signs of severity related to the seizure.…”
Section: Comments and Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…According to the literature, apart from specific situations (state of illness, underlying etiology with high potential for recurrence), it is not reasonable to offer long-term treatment [15]. Obviously, optimal management depends on the etiology and severity of the attack [7]. Hospitalization mainly concerned patients with signs of severity related to the seizure.…”
Section: Comments and Discussionmentioning
confidence: 99%
“…Etiologic research requires detailed clinical examination, laboratory and imaging examinations [4] [5]. Computed tomography should not be routine unless there is a suggestive clinical history or persistent disturbances of consciousness [6] [7]. The cost of these investigations is a major concern in poor countries.…”
Section: Introductionmentioning
confidence: 99%
“…The major target for antiseizure drugs is the GABA A receptor (GABA A R), which are found in the limbic system of the brain. Benzodiazepines (BZDs) are considered as the treatment of choice for acute management of severe seizures in both adults and children, except in infants less than two weeks of age in whom phenobarbitone is preferred [13]. Benzodiazepines are known to be positive allosteric modulators of GABA A receptors.…”
Section: Treatment Options For Arsmentioning
confidence: 99%
“…[10][11][12] Hence, in order to get rid of seizures and broaden the life span, particularly of the pediatric patients, as they are expected to live longer, curative perspective is needed. 13 Traditionally, phenobarbital and phenytoin are exclusively used to treat refractory epilepsy but only 50%-80% of the patients are comprehensively managed by these drugs. 14 It is a matter of concern that in the long run, some negative effects are associated with phenobarbital as observed in animals that there was an increase in neuronal apoptosis and in children induced cognitive impairment.…”
Section: Introductionmentioning
confidence: 99%