Management of an outbreak of Enterobacter cloacae in a neonatal unit using simple preventive measures

Dijk, Yvonne van; Bik, Elisabeth M.; Hochstenbach-Vernooij, S.; Vlist, Gert J. van der; Savelkoul, Paul H. M.; Kaan, J. A.; Diepersloot, R.J.A.

doi:10.1053/jhin.2002.1186

Cited by 46 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Other infections include lower respiratory tract infections, skin and soft tissue infections, urinary tract infections, endocarditis, osteomyelitis and ophthalmic infections. 6 …”

Section: Introductionmentioning

confidence: 99%

Phenotypic characterization of ESBL producing Enterobacter cloacae among children

Amin

Zafar

Ejaz³

et al. 2012

Pak J Med Sci

View full text Add to dashboard Cite

Objective: The emergence of ESBL producing Enterobacter cloacae in clinical isolates is posing a serious threat for treating nosocomial infections. The aim of the study was to determine the frequency of extended spectrum β-lactamase (ESBL) producing Enterobacter cloacae and to compare the phenotypic methods used for the characterization of ESBL producing strains. Methodology: This cross sectional observational study was conducted during April 2011 to March 2012 at Microbiology department of The Children’s Hospital and Institute of Child Health, Lahore. A total number of 20,257 various clinical samples were analyzed during the study period. Enterobacter cloacae were identified using API 20E system and ESBL detection was carried out using double-disk synergy test (DDST) and CLSI confirmatory test. Results: Enterobacter cloacae were isolated from 221 samples, out of which 33 (14.93%) were ESBL producers and 188 (85.07%) were non-ESBL producers. The gender distribution of ESBL producing Enterobacter cloacae was 21 (63.6%) in males and 12 (36.4%) in females. Highest frequency (63%) of ESBL producing Enterobacter cloacae was detected in blood samples. Comparison of DDST and CLSI confirmatory test showed that 25 (75.75%) isolates were characterized by DDST and 33 (100%) using CLSI confirmatory test. Conclusion: The present study shows moderately high frequency of ESBL producing Enterobacter cloacae among children. DDST was found to be less efficient in ESBL detection as compared to CLSI confirmatory test.

show abstract

“…5 Other infections include lower respiratory tract infections, skin and soft tissue infections, urinary tract infections, endocarditis, osteomyelitis and ophthalmic infections. 6 …”

Section: Introductionmentioning

confidence: 99%

Phenotypic characterization of ESBL producing Enterobacter cloacae among children

Amin

Zafar

Ejaz³

et al. 2012

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…Nosocomial outbreaks of E. cloacae bloodstream infection in paediatric intensive care units (ICUs) have been reported. 2,3 Since the introduction of extended-spectrum cephalosporins, the prevalence of Gram-negative pathogens resistant to these antibiotics has been increasing. 4 Although antimicrobial resistance arises via several mechanisms, the most important is the production of enzymes that hydrolyse the b-lactam ring.…”

Section: Introductionmentioning

confidence: 99%

Nosocomial and community-acquired Enterobacter cloacae bloodstream infection: risk factors for and prevalence of SHV-12 in multiresistant isolates in a medical centre

Liu

Wang

Lee

et al. 2004

Journal of Hospital Infection

View full text Add to dashboard Cite

“…Congenital transmission of E. cloacae has not been reported. Outbreaks of E. cloacae infection in intensive care units and burn units have been described frequently [7].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple reports have incriminated the hands of personnel, endoscopes, thermometers, and blood gas machines as potential sources of infection. Also implicated have been a variety of colloid and crystalloid solutions [1,6,7]. E. cloacae commonly cause respiratory and central nervous system infection, but skin and soft tissue infection have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Enterobacter cloacae: an “ICU bug” causing community acquired necrotizing meningo-encephalitis

Maheshwari

Shefler

2008

Eur J Pediatr

View full text Add to dashboard Cite

Enterobacter cloacae is a gram negative bacillus that is ubiquitous as a contaminant and a pathogen in adult, paediatric, and neonatal ICUs. Its transmission is almost exclusively nosocomial with community acquired infection reported rarely. We report a case of community acquired, rapidly progressive E. cloacae meningo-encephalitis in a neonate. A three-week-old term infant presented from home, having been discharged from hospital within two days of delivery. She rapidly progressed to multi-organ dysfunction. Initial CT of her brain showed evidence of severe hypoxic changes and herniation of the frontal lobes through the anterior fontanelle. Care was withdrawn 72 hours after admission. Post mortem examination confirmed E.cloacae meningo-encephalitis as a cause of her death. The baby had not been in a critical care environment at any time before admission, making it highly likely to have been a community acquired infection. Transmission of the organism may have been vertical as maternal transmission with intestinal colonization of neonates with E. cloacae has previously been reported. This case confirms that infection with E. cloacae should be included in the differential diagnosis of any severely ill neonate presenting from the community, and antimicrobial therapy should be optimized accordingly.

show abstract

Management of an outbreak of Enterobacter cloacae in a neonatal unit using simple preventive measures

Cited by 46 publications

References 23 publications

Phenotypic characterization of ESBL producing Enterobacter cloacae among children

Phenotypic characterization of ESBL producing Enterobacter cloacae among children

Nosocomial and community-acquired Enterobacter cloacae bloodstream infection: risk factors for and prevalence of SHV-12 in multiresistant isolates in a medical centre

Enterobacter cloacae: an “ICU bug” causing community acquired necrotizing meningo-encephalitis

Contact Info

Product

Resources

About