Management of aplastic anemia

Nissen, C; Gratwohl, Aloïs; Speck, B

doi:10.1111/j.1600-0609.1991.tb00539.x

Cited by 16 publications

(3 citation statements)

References 37 publications

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“…Some studies have suggested a role for GSH depletion in the progression of amyotrophic lateral sclerosis (ALS) [128], a neurodegenerative disease that causes muscular atrophy and paralysis [83]. However, conclusions have been mixed, with some researchers indicating no change in GSH levels [129,130]. At present, the role of ferroptosis in ALS is unclear and requires further research.…”

Section: Conclusion Limitations and Further Directionsmentioning

confidence: 99%

Ferroptosis and Its Role in Diverse Brain Diseases

et al. 2018

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Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer's disease, and Parkinson's disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.

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Section: Conclusion Limitations and Further Directionsmentioning

confidence: 99%

Ferroptosis and Its Role in Diverse Brain Diseases

et al. 2018

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“…The role of androgens on erythropoiesis is known since 1941 [ 34 ] when, before the availability of recombinant human EPO, they represented the main pharmacologic agents in the treatment of anemia of chronic and end-stage renal disease, as well as aplastic anemia [ 35 , 36 ].…”

Section: Testosterone and Anemiamentioning

confidence: 99%

The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones

Maggio

Vita

Fisichella

et al. 2015

International Journal of Endocrinology

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Anemia is a multifactorial condition whose prevalence increases in both sexes after the fifth decade of life. It is a highly represented phenomenon in older adults and in one-third of cases is “unexplained.” Ageing process is also characterized by a “multiple hormonal dysregulation” with disruption in gonadal, adrenal, and somatotropic axes. Experimental studies suggest that anabolic hormones such as testosterone, IGF-1, and thyroid hormones are able to increase erythroid mass, erythropoietin synthesis, and iron bioavailability, underlining a potential role of multiple hormonal changes in the anemia of aging. Epidemiological data more consistently support an association between lower testosterone and anemia in adult-older individuals. Low IGF-1 has been especially associated with anemia in the pediatric population and in a wide range of disorders. There is also evidence of an association between thyroid hormones and abnormalities in hematological parameters under overt thyroid and euthyroid conditions, with limited data on subclinical statuses. Although RCTs have shown beneficial effects, stronger for testosterone and the GH-IGF-1 axis and less evident for thyroid hormones, in improving different hematological parameters, there is no clear evidence for the usefulness of hormonal treatment in improving anemia in older subjects. Thus, more clinical and research efforts are needed to investigate the hormonal contribution to anemia in the older individuals.

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“…Androgens have been known to have a stimulatory effect on erythropoiesis for over three decades28 and hormonal treatment remains effective for some patients with hypoplastic or aplastic anemia 29. Patients with androgen deficiency, such as observed after orchiectomy or pharmacologic androgen ablation for prostate cancer, typically have a drop in hemoglobin level of 1 g/dL,30–32 but this can be as high as 2.5 g/dL in patients who have had complete hormonal ablation and radiotherapy 33.…”

Section: Mechanisms Of Ua: Contributing Factorsmentioning

confidence: 99%

Unexplained Anemia in the Elderly

Makipour

Kanapuru

Ershler

2008

Seminars in Hematology

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Among the elderly, anemia occurs with increasing frequency with each advancing decade. Unlike when anemia occurs in younger adults, the cause of anemia in the elderly is oftentimes not readily apparent or attributable to a single cause. However, this commonly observed form of anemia in the elderly (termed unexplained anemia [UA]) can generally be dissected to its root causes, which include renal insufficiency, inflammation, testosterone deficiency, and stem cell proliferative decline. Myelodysplasia (MDS) occurs commonly in this age group but can and should, for both diagnostic and therapeutic considerations, be distinguished from UA.

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Management of aplastic anemia

Cited by 16 publications

References 37 publications

Ferroptosis and Its Role in Diverse Brain Diseases

Ferroptosis and Its Role in Diverse Brain Diseases

The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones

Unexplained Anemia in the Elderly

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