Management of Childhood Onset Nephrotic Syndrome

Gipson, Debbie S.; Massengill, Susan F.; Yao, Lynne; Nagaraj, Shashi; Smoyer, William E.; Mahan, John D.; Wigfall, Delbert R.; Miles, Paul V.; Powell, Leslie M.; Lin, Jen Jar; Trachtman, Howard; Greenbaum, Larry A.

doi:10.1542/peds.2008-1559

Cited by 267 publications

(220 citation statements)

References 88 publications

Supporting

Mentioning

202

Contrasting

Unclassified

Order By: Relevance

“…Steroid-resistant, steroid-sensitive, infrequently relapsing, frequently relapsing, and steroid-dependent NS were classified as per standard definitions (12). The method of laboratory determination of creatinine value was noted (Jaffe or isotope dilution mass spectrometry).…”

Section: Data Source and Case Definitionsmentioning

confidence: 99%

AKI in Children Hospitalized with Nephrotic Syndrome

Rheault¹,

Zhang²,

Selewski³

et al. 2015

Clinical Journal of the American Society of Nephrology

Self Cite

101

View full text Add to dashboard Cite

Background and objectives Children with nephrotic syndrome can develop life-threatening complications, including infection and thrombosis. While AKI is associated with adverse outcomes in hospitalized children, little is known about the epidemiology of AKI in children with nephrotic syndrome. The main objectives of this study were to determine the incidence, epidemiology, and hospital outcomes associated with AKI in a modern cohort of children hospitalized with nephrotic syndrome.Design, setting, participants, & measurements Records of children with nephrotic syndrome admitted to 17 pediatric nephrology centers across North America from 2010 to 2012 were reviewed. AKI was classified using the pediatric RIFLE definition.Results AKI occurred in 58.6% of 336 children and 50.9% of 615 hospitalizations (27.3% in stage R, 17.2% in stage I, and 6.3% in stage F). After adjustment for race, sex, age at admission, and clinical diagnosis, infection (odds ratio, 2.24; 95% confidence interval, 1.37 to 3.65; P=0.001), nephrotoxic medication exposure (odds ratio, 1.35; 95% confidence interval, 1.11 to 1.64; P=0.002), days of nephrotoxic medication exposure (odds ratio, 1.10; 95% confidence interval, 1.05 to 1.15; P,0.001), and intensity of medication exposure (odds ratio, 1.34; 95% confidence interval, 1.09 to 1.65; P=0.01) remained significantly associated with AKI in children with nephrotic syndrome. Nephrotoxic medication exposure was common in this population, and each additional nephrotoxic medication received during a hospitalization was associated with 38% higher risk of AKI. AKI was associated with longer hospital stay after adjustment for race, sex, age at admission, clinical diagnosis, and infection (difference, 0.45 [log]days; 95% confidence interval, 0.36 to 0.53 [log]days; P,0.001).Conclusions AKI is common in children hospitalized with nephrotic syndrome and should be deemed the third major complication of nephrotic syndrome in children in addition to infection and venous thromboembolism. Risk factors for AKI include steroid-resistant nephrotic syndrome, infection, and nephrotoxic medication exposure. Children with AKI have longer hospital lengths of stay and increased need for intensive care unit admission.

show abstract

Section: Data Source and Case Definitionsmentioning

confidence: 99%

AKI in Children Hospitalized with Nephrotic Syndrome

Rheault¹,

Zhang²,

Selewski³

et al. 2015

Clinical Journal of the American Society of Nephrology

Self Cite

101

View full text Add to dashboard Cite

show abstract

“…Beyond these trials, most experience with the use of corticosteroids for adults with MCD is extrapolated from large prospective randomized controlled trials in children 31,32 and observational studies in children and adults. 18,19,22,23 Intravenous Versus Oral Steroid Therapy The effects of initial therapy with intravenous methylprednisolone compared with oral prednisone in adult MCD have been studied in two randomized trials.…”

Section: Efficacymentioning

confidence: 99%

The Treatment of Minimal Change Disease in Adults

Hogan

Radhakrishnan

2013

Journal of the American Society of Nephrology

133

123

View full text Add to dashboard Cite

Minimal change disease (MCD) is the etiology of 10%-25% of cases of nephrotic syndrome in adults. The mainstay of treatment for adult MCD, oral gucocorticoids, is based on two randomized controlled trials and extensive observational data in adults, and this treatment leads to remission in over 80% of cases. Relapses are common, and some patients become steroid-resistant (SR), steroid-dependent (SD), or frequently relapsing (FR). The data guiding the treatment of these patients are limited. Here, we review MCD in adults with particular focus on the evidence for immunosuppressive therapy in these patients.

show abstract

“…Nephrotic syndrome (NS) in children is a common, yet challenging, relapsing, and remitting renal disorder and exhibits a heterogeneous clinical phenotype ranging from a single episode, infrequently relapsing, frequently relapsing to steroid-resistant disease [1]. Although 80% of these children are corticosteroid responsive, nearly half of them demonstrate a frequently relapsing or steroid-dependent course, often resulting in multiple complications, hospitalizations, or even chronic renal failure [2].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Pediatric Patients with Minimal Change Disease

El-Gamasy¹,

Abdelmageed²

2017

IJPCC

View full text Add to dashboard Cite

Objectives: This study was conducted to assess the quality of life (QOL) in children between 2 and 18 years of age with Minimal Change Disease (MCD) as the commonest variant of primary idiopathic nephrotic syndrome (NS) using validated arabic version of Pediatric Quality of Life Inventory (PedsQL™ 4.0 Generic Core Scales). Subjects:This cross-sectional comparative study was conducted in Tanta University Hospital (TUH), Pediatric nephrology inpatient unit or outpatient clinic between October 2016 and October 2017. In this questionnaire-based study, 100 children with primary idiopathic NS and an equal number of age-matched controls with other chronic diseases were included. Their clinical and demographic details were recorded and QOL was assessed using PedsQL™ 4.0 Generic Core Scales.Conclusions: The present study shows that the overall QOL in children with MCD was better than in children with other chronic illnesses.

show abstract

Management of Childhood Onset Nephrotic Syndrome

Cited by 267 publications

References 88 publications

AKI in Children Hospitalized with Nephrotic Syndrome

AKI in Children Hospitalized with Nephrotic Syndrome

The Treatment of Minimal Change Disease in Adults

Quality of Life in Pediatric Patients with Minimal Change Disease

Contact Info

Product

Resources

About