Management of Chronic Wounds

Morrison, Anne; Madden, Charles S.; Messmer, John

doi:10.1016/j.pop.2021.10.009

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Chronic wounds are defined as those that have failed to proceed through an orderly and timely series of events to produce a durable structural and functional closure [ 5 ]. The main characteristic of chronic wounds is the low partial pressure of oxygen at the centre of the wound, which hinders healing [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds

Capó

Monserrat-Mesquida

Quetglas-Llabrés

et al. 2023

IJMS

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Hyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the plasma oxidative and inflammation biomarkers and growth factors in patients with chronic diabetic wounds. The participants received 20 HBOT sessions (five sessions/week), and blood samples were obtained at sessions 1, 5 and 20, before and 2 h after the HBOT. An additional (control) blood sample was collected 28 days after wound recovery. No significant differences were evident in haematological parameters, whereas the biochemical parameters progressively decreased, which was significant for creatine phosphokinase (CPK) and aspartate aminotransferase (AST). The pro-inflammatory mediators, tumour necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β), progressively decreased throughout the treatments. Biomarkers of oxidative stress––plasma protein levels of catalase, extracellular superoxide dismutase, myeloperoxidase, xanthine oxidase, malondialdehyde (MDA) levels and protein carbonyls––were reduced in accordance with wound healing. Plasma levels of growth factors––platelet-derived growth factor (PDFG), transforming growth factor β (TGF-β) and hypoxia-inducible factor 1-alpha (HIF-1α)–– were increased as a consequence of HBOT and reduced 28 days after complete wound healing, whereas matrix metallopeptidase 9 (MMP9) progressively decreased with the HBOT. In conclusion, HBOT reduced oxidative and pro-inflammatory mediators, and may participate in activating healing, angiogenesis and vascular tone regulation by increasing the release of growth factors.

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Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds

Capó

Monserrat-Mesquida

Quetglas-Llabrés

et al. 2023

IJMS

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Encoder–decoder semantic segmentation models for pressure wound images

Eldem

Ülker

Işıklı³

2022

The Imaging Science Journal

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Characteristics of Wound Infections and Methods of Their Treatment Using Preparations of Biological Origin

Oliinyk¹

2022

Biotechnol. acta

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Surgical wound infections are the most common patients’ complications in the postoperative period. In the modern clinic, they worsen the disease prognosis and remain the most important and acute health problem in all countries of the world. The aim of the work was to analyze current scientific data on the peculiarities of the pathogenesis of wound infections and types of their pathogens, as well as drugs of biological origin in the treatment of wound infections. The paper discusses in detail the problem of infection of wound injuries during surgery and domestic injuries of various kinds. The main pathogens of wound infections are considered. Specific pathogenicity factors for bacteria of the genera Staphylococcus, Pseudomonas, Enterobacteriaceae were analyzed. Based on the analysis of literature sources, a list of drugs of biotechnological origin that can be effectively used in combination therapy for the treatment and prevention of wound infections was determined. Conclusions. The result is the identification of those mechanisms of pathogenesis of wound infections that determine the effectiveness of the use of drugs of biological origin in this pathology treatment.

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Management of Chronic Wounds

Cited by 3 publications

References 25 publications

Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds

Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds

Encoder–decoder semantic segmentation models for pressure wound images

Characteristics of Wound Infections and Methods of Their Treatment Using Preparations of Biological Origin

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