Management of cystic fibrosis-related diabetes in children and adolescents

O’Riordan, Stephen; Robinson, Paul D.; Donaghue, Kim C.; Moran, Antoinette

doi:10.1111/j.1399-5448.2009.00587.x

Cited by 66 publications

(118 citation statements)

References 54 publications

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“…Its complete aetiology remains unclear. However, it is known that CFRD is characterised primarily by insulin deficiency and secondarily by insulin resistance [20,21]. Therefore, vitamin D might theoretically exert certain glucose-lowering effects even in this type of diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

et al. 2011

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Aims/hypothesis Many cystic fibrosis patients are vitamin D-insufficient. Cystic fibrosis-related diabetes is a major complication of cystic fibrosis. The literature suggests that vitamin D might possess certain glucose-lowering properties. We aimed to assess the relationship between vitamin D and cystic fibrosis-related glucose intolerance. Methods We enrolled 898 cystic fibrosis patients from Sweden, Norway and Denmark. Vitamin D intake was assessed using a seven-day food record. Serum 25-hydroxyvitamin D (s25OHD) and HbA 1c were measured, and an OGTT was carried out. Multiple linear and logistic regressions were used for HbA 1c and cystic fibrosis-related diabetes/OGTT result as outcome variables, respectively. Each model was controlled for country, and for known cystic fibrosis-related diabetes risk factors: age, sex, genotype, liver dysfunction, long-term corticosteroid treatment, and lung and pancreatic function. Results Degree of vitamin D insufficiency (OR 1.36; p=0.032) and s25OHD<30 nmol/l (OR 1.79; p=0.042) were significant risk factors for cystic fibrosis-related diabetes. Accordingly, HbA 1c value was positively associated with s25OHD< 30 nmol/l and<50 nmol/l, as well as with degree of vitamin D insufficiency (adjusted R 2 =20.5% and p<0.05 in all).Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 99%

“…It clearly shares pathological features both with type 1 and type 2 diabetes [20]. It is generally agreed that CFRD primarily results from an insulin-insufficient state, which is aggravated by worsening insulin resistance [21].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

et al. 2011

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“…clinical practice guidelines for the management of CFRD recommend a combination of basal (long-acting) and bolus (rapid-acting) insulin [21]. Pump insulin therapy offers the greatest flexibility and a reduction in the number of injections required [22];…”

Section: Cfrd Current Managementmentioning

confidence: 99%

“…and are titrated to fasting blood glucose levels with suggested pre-meal insulin doses of 0.5-1u per 15g of carbohydrate and 'correction' doses added as required [21].…”

Section: Cfrd Current Managementmentioning

confidence: 99%

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Cystic fibrosis related diabetes—a new perspective on the optimal management of postprandial glycemia

Perano

Rayner

Couper

et al. 2014

Journal of Diabetes and its Complications

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