Management of depressive symptoms in peri- and postmenopausal women: EMAS position statement

Stute, Petra; Spyropoulou, Anastasia; Karageorgiou, Vasilios; Cano, Antonio; Bitzer, Johannes; Ceaușu, Iuliana; Chedraui, Peter; Durmuşoğlu, Fatih; Erkkola, Risto; Goulis, Dimitrios G.; Hirschberg, Angelica Lindén; Kiesel, L.; Lopès, P.; Pines, Amos; Rees, Margaret; Trotsenburg, Mick van; Zervas, Iannis M.; Lambrinoudaki, Ιrene

doi:10.1016/j.maturitas.2019.11.002

Cited by 79 publications

(51 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased time in the corners of the open field in the VCD-Vehicle group indicates that the endogenous hormone profile associated with transitional menopause without subsequent hormone therapy increases anxiogenic behavior compared to the profile of transitional menopause with E2-only or progesterone-only administration. This observation corresponds to clinical literature showing increased de novo affective disorders during midlife and the transition to menopause, and calls for further evaluations of midlife-aged individuals given these hormone therapies ( Bromberger and Kravitz, 2011 ; Maki et al, 2012 ; Weber et al, 2014 ; Soares, 2019 ; Parry, 2020 ; Stute et al, 2020 ). Overall, the combination of E2 and levonorgestrel produced a favorable profile of reduced anxiety-like behaviors compared to other groups.…”

Section: Discussionsupporting

confidence: 86%

“…Depriving the female system of ovarian-derived hormones leads to cognitive changes in both humans and animal models (e.g., Phillips and Sherwin, 1992 ; Singh et al, 1994 ; Bimonte and Denenberg, 1999 ; Nappi et al, 1999 ; Heikkinen et al, 2004 ; Wallace et al, 2006 ; Rocca et al, 2007 ; Gibbs and Johnson, 2008 ; Parker et al, 2009 ; Ryan et al, 2014 ). Importantly, ovarian hormone loss also results in an increased susceptibility to anxiety and depression ( Parker et al, 2009 ; Bromberger and Kravitz, 2011 ; Bromberger et al, 2011 ; Maki et al, 2012 ; Weber et al, 2014 ; Parry, 2020 ; Soares, 2020 ; Stute et al, 2020 ). Under certain parameters or experimental conditions, estrogen supplementation following the surgical removal of the ovaries (ovariectomy; Ovx) reverses or attenuates detriments in cognition and affective behaviors in preclinical models ( Bimonte and Denenberg, 1999 ; Holmes et al, 2002 ; Foster et al, 2003 ; Hiroi and Neumaier, 2006 ; Hiroi et al, 2006 , 2016 ; Fernandez et al, 2008 ; Harburger et al, 2009 ; Rodgers et al, 2010 ; Gleason et al, 2015 ; Black et al, 2016 , 2018 ; Koebele et al, 2020b ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause

Koebele

Hiroi

Plumley

et al. 2021

Front. Behav. Neurosci.

View full text Add to dashboard Cite

A variety of U.S. Food and Drug Administration-approved hormone therapy options are currently used to successfully alleviate unwanted symptoms associated with the changing endogenous hormonal milieu that occurs in midlife with menopause. Depending on the primary indication for treatment, different hormone therapy formulations are utilized, including estrogen-only, progestogen-only, or combined estrogen plus progestogen options. There is little known about how these formulations, or their unique pharmacodynamics, impact neurobiological processes. Seemingly disparate pre-clinical and clinical findings regarding the cognitive effects of hormone therapies, such as the negative effects associated with conjugated equine estrogens and medroxyprogesterone acetate vs. naturally circulating 17β-estradiol (E2) and progesterone, signal a critical need to further investigate the neuro-cognitive impact of hormone therapy formulations. Here, utilizing a rat model of transitional menopause, we administered either E2, progesterone, levonorgestrel, or combinations of E2 with progesterone or with levonorgestrel daily to follicle-depleted, middle-aged rats. A battery of assessments, including spatial memory, anxiety-like behaviors, and depressive-like behaviors, as well as endocrine status and ovarian follicle complement, were evaluated. Results indicate divergent outcomes for memory, anxiety, and depression, as well as unique physiological profiles, that were dependent upon the hormone regimen administered. Overall, the combination hormone treatments had the most consistently favorable profile for the domains evaluated in rats that had undergone experimentally induced transitional menopause and remained ovary-intact. The collective results underscore the importance of investigating variations in hormone therapy formulation as well as the menopause background upon which these formulations are delivered.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause

Koebele

Hiroi

Plumley

et al. 2021

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Both social network size and intimacy were classi ed into quartiles based on a previous study [39]. Statistical modeling and adjusted variables were selected based on prior work, which related to social network status or depression: Statistical modeling and adjusted variables were selected based on prior work, which related to social network status or depression: (1) adjusted for age, gender, and menopause status [40]; (2) additionally adjusted for marital status, education, and income status [41]; (3) additionally adjusted for number of comorbidities, smoking, alcohol intake, and physical activity [42]; and (4) adjusted for social network size or intimacy [4]. We reported results as odds ratios (ORs) and 95% con dence intervals (CIs), and indicate a p-for trend to con rm dose-response.…”

Section: Discussionmentioning

confidence: 99%

Association between social network characteristics and depressive symptoms in South Korean adults: The moderating roles of age diversity and age difference

Jeon

Jung

Heo

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: This study aimed to examine the association between size and intimacy of social networks and substantial depressive symptoms, and further, to assess the moderating roles of age diversity and age difference in these linkages, in the community-dwelling adult population in South Korea.Methods: A South Korean population of 2,363 in the Cardiovascular and Metabolic Disease Etiology Research Center cohort was utilized. Each participant’s social network characteristics were measured using the egocentric social network analysis tool. Substantial depressive symptoms were assessed using the Beck Depression Inventory-II (BDI-II). Multivariable logistic regression was used to compute odds ratios (ORs) for substantial depressive symptoms by different social network characteristics.Results: Mean perceived intimacy of social networks had an inverse association with substantial depressive symptoms; Overall, the size of social networks had a negative association with depressive symptoms. In women, age diversity and age difference had moderation effects on the association of network size and intimacy with substantial depressive symptoms. The association of network size and intimacy with substantial depressive symptoms was stronger than women’s average (OR=3.23; 95% CI=1.91-5.47) when social networks had a higher age diversity (OR=4.95; 2.32-10.51) and higher age differences (OR=5.38; 2.22-13.05).Limitations: Substantial Depressive symptoms were measured according to self-assessed levels of depressive symptoms during the previous two weeks, which do not necessarily indicate depressive disorder. Categorization of certain variables was made considering the distribution, but not with the actual critical known cut-off.Conclusions: We found that low social network size and intimacy were linearly associated with substantial depressive symptoms in women. Women whose networks are small-sized, less intimate, and with high age diversity and age difference, especially with older persons are more likely to have depressive symptoms in South Korean settings.Trial registration: KCT0001038, Clinical Research Information Service (CRIS)

show abstract

“…Значущим фактором ризику виникнення КС тяжкого ступеня була наявність хронічного стресу в анамнезі та тривожності. У перименопаузі в жінок спостерігається зниження вмісту естрадіолу і підвищення рівня гонадотропних гормонів, значення яких у розвитку КС не підлягає сумнівам [12], що може супроводжуватися зростанням частоти депресивних станів та відчуттям тривоги [13,14] у жінок у віці менопаузного переходу. Окремі дослідження підтверджують взаємозв'язок між наявністю хронічного стресу в анамнезі та вираженими клінічними проявами КС [15].…”

Section: обговоренняunclassified

Predicting the risk of severe menopausal syndrome in perimenopausal women with hypothyroidism

Пасечко

Chukur

Bob

et al. 2021

Mìžnarodnij endokrinologìčnij žurnal

View full text Add to dashboard Cite

Background. Every year the number of menopausal women increases. At this age, the prevalence of hypothyroidism (HT) reaches its peak. The problem of menopausal syndrome (MS) is relevant for patients with HT, concomitant endocrine disorders create a background for combination with dyshormonal factors. The purpose of the study: to propose an approach to predicting the risk of severe MS in perimenopausal women with HT according to the developed algorithm and mathematical model. Materials and methods. To predict the development of MS, 146 perimenopausal women with autoimmune HT were surveyed. Using multiple regression analysis, a prognostic model of the risk of severe MS was created. Results. Logistic regression analysis revealed the following most significant multicollinear risk factors for MS: smoking, alcohol consumption, adverse environmental conditions, physical activity, history of stress and anxiety, thyroid disease. A correlation matrix with calculation of regression coefficients and coefficient of determination was constructed, a mathematical model was created to determine the risk factor for the progression of MS. The predicted value of the risk factor for severe MS with a high degree of probability was determined in 72 (49.32 %) women, with an average probability — in 58 (39.73 %), and with a low probability — in 16 women (10.95 %) with HT. The correspondence of the predicted results with the theoretically expected ones in the high-risk group was recorded in 104.37 %, in the average-risk — in 94.73 %, and in the low-risk — in 89.65 % of cases. Conclusions. The developed algorithm and mathematical model for predicting severe MS on the background of HT are highly informative and allow determining in advance the group of women at high risk of severe MS for the timely implementation of appropriate preventive measures.

show abstract

Management of depressive symptoms in peri- and postmenopausal women: EMAS position statement

Cited by 79 publications

References 93 publications

Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause

Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause

Association between social network characteristics and depressive symptoms in South Korean adults: The moderating roles of age diversity and age difference

Predicting the risk of severe menopausal syndrome in perimenopausal women with hypothyroidism

Contact Info

Product

Resources

About