2017
DOI: 10.1530/eje-16-0276
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MANAGEMENT OF ENDOCRINE DISEASE: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy

Abstract: Subclinical thyrotoxicosis is a condition affecting up to 10% of the population in some studies. We have reviewed literature and identified studies describing prevalences, causes and outcomes of this condition. Treatment should be considered in all subjects if this biochemical abnormality is persistent, especially in case of symptoms of thyrotoxicosis or in the presence of any complication. In particular, treatment should be offered in those subclinically thyrotoxic patients with a sustained serum TSH below 0.… Show more

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Cited by 38 publications
(29 citation statements)
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“…Thyrotoxicosis was found in about 20% of our patients and several others showed serum TSH in the lower part of the reference range. These findings suggest that COVID-19 may favor the development of thyrotoxicosis at a higher incidence than that expected in the general population (17). Although our study was not designed to clarify the mechanisms responsible for thyroid dysfunction in patients with COVID-19, it is reasonable to hypothesize that thyrotoxicosis was caused by destructive thyroiditis.…”
Section: :4 385 Clinical Studymentioning
confidence: 78%
“…Thyrotoxicosis was found in about 20% of our patients and several others showed serum TSH in the lower part of the reference range. These findings suggest that COVID-19 may favor the development of thyrotoxicosis at a higher incidence than that expected in the general population (17). Although our study was not designed to clarify the mechanisms responsible for thyroid dysfunction in patients with COVID-19, it is reasonable to hypothesize that thyrotoxicosis was caused by destructive thyroiditis.…”
Section: :4 385 Clinical Studymentioning
confidence: 78%
“…At two-thirds of the total number of patients with GD, this would suggest a higher than expected prevalence of the disease and therefore may suggest iodine deficiency in Portugal [7,8]. In fact, literature suggests TNG to be responsible for only 10-20% of cases of hyperthyroidism [29][30][31][32]. Given the numbers as before this would suggest that around one-third of the patients were being treated at any moment by the specialists, a higher ratio than that found for GD.…”
Section: Tngmentioning
confidence: 99%
“…Patients are also mostly female, and significantly older as expected; the thyroid was enlarged in most patients and thyroid nodules were always found; hyperthyroidism was slightly less severe, with an increased T3/T4 ratio lower than in GD with higher Tg levels. Less patients than those with GD were already being treated at the first appointment perhaps in relation with less severe hyperthyroidism, but it should be noted that 11% had already been treated with what was supposed to be a definitive treatment-either thyroidectomy or radioactive iodine [8,13,14,[29][30][31][32].…”
Section: Tngmentioning
confidence: 99%
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