Lichenoid dermatitis is a type of chronic eczema. Eczema can be correlated with Vicharchika (~wet eczema) described in Ayurveda. In acute conditions, this disease responds well to treatment, but in chronic presentations, it is difficult to manage due to its recurrent nature. Panchakarma (~five biopurification therapies) is well-known measure to improve the quality of life and prevention of recurrence in chronic diseases. In this case report, a 27-year-old male patient presented with chronic lichenoid dermatitis having symptoms of Kandu (~itching), Daha (~burning sensation), Ruja (~pain), Pidaka (~papules/eruptions), Srava (~discharge), Vaivarnya (~discoloration), and Rukshata (~dryness) treated with Ayurvedic interventions. Virechana (~therapeutic purgation) along with Ayurvedic oral medicines and wholesome dietary regimen were given for 12 weeks. Encouraging relief in various symptoms was observed after treatment. Rasayana (~rejuvenation) was also given to patient for prevention of recurrence. The patient has shown well tolerance and satisfactory adherence to treatment. No adverse event was reported during the course of therapy. After three months of treatment, disease progression was fully stopped and lesions resolved completely.