Management of inflammatory bowel diseases in Eastern Europe

Abstract

Limited data are available on the management of inflammatory bowel diseases (IBD) in East European countries. The diagnostic tools and most treatment options are also available in Eastern Europe. The diagnostic procedures commonly used became more sophisticated in the past few years, with a greater use of computed tomography/magnetic resonance imaging and serology testing; however, double contrast barium enema, enteroclysis, and endoscopy remained standard. The medical therapy and surgical strategies are also somewhat different from those applied in Western countries. In ulcerative colitis, besides mesalazine, the use of sulphasalazine is still frequent, while azathioprine is only used in a minority of patients. The use of conventional corticosteroids is common and the rate of non-colorectal cancer associated colectomies is low. In contrast, 5-aminosalicylates are still used for maintenance in Crohn's disease and azathioprine is generally less frequently given compared with Western Europe. Biological agents have also become available about five years ago, yet their use is restricted mainly to specialised centres.

Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

“…Chronic continuous disease (Ͼ1 flare-up/year) was seen in 24.2%, while extraintestinal manifestations were present in 28.4% of patients. The rate of colectomy due to a nonmalignant disease was, in accordance with previous reports from Eastern Europe, 33 as low as 5.2%. Detailed clinical phenotypes were determined by thoroughly reviewing the patients' medical charts that had been collected in a uniform format.…”

Seroreactivity to microbial components in Crohnʼs disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients

“…Chronic continuous disease (Ͼ1 flare-up/year) was seen in 24.2%, while extraintestinal manifestations were present in 28.4%. The rate of colectomy due to a nonmalignant disease was, in accordance with previous reports from Eastern Europe, 32 as low as 5.2%.…”

Mannose-binding lectin level and deficiency is not associated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort

“…Chronic continuous disease (Ͼ1 flare-up/year) was seen in 24.2% of patients, whereas EIM were present in 28.4% of patients. The rate of colectomy because of a nonmalignant disease, in accordance with previous reports from Eastern Europe [36], was as low as 5.2%. Detailed clinical phenotypes were determined by thoroughly reviewing the patients' medical charts that had been collected in a uniform format.…”