Management of intrauterine adhesions: A novel intrauterine device

Tu, Chunhua; Yang, Xiaoli; Qin, Xiaoyun; Cai, Liping; Zhang, Ping

doi:10.1016/j.mehy.2013.05.028

Cited by 15 publications

(19 citation statements)

References 17 publications

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“…Evidence now supports a broad range of functions for chemokines would play a positive role in the growth of exterior endometrial stem cells and final regeneration of functional endometrium [22, 64]. …”

Section: Discussionmentioning

confidence: 99%

“…It was speculated that an IUD could help the physiological endometrial regeneration by separating the anterior and posterior uterine walls, although many authors have reported good results [20, 21]. Many investigators support the use of IUDs (especially the Lippes loop) for prevention of recurrent IUAs [2, 17, 22–24]. Other studies reported that copper-bearing and Progestasert (Alza Corporation, Palo Alto, CA) IUDs may have a rather small surface area and may not be able to prevent adhesion reformation.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Salma

Xue

Sheikh

et al. 2014

BioMed Research International

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The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations in these publications. There were 28 studies included for a systematic review. Of these, 5 studies were eligible for meta-analysis and 23 for qualitative assessment only. Twenty-eight studies related to the use of IUDs as ancillary treatment following adhesiolysis were identified. Of these studies, 25 studies at least one of the following methods were carried out as ancillary treatment: Foley catheter, hyaluronic acid gel, hormonal therapy, or amnion graft in addition to the IUD. There was one study that used IUD therapy as a single ancillary treatment. In 2 studies, no adjunctive therapy was used after adhesiolysis. There was a wide range of reported menstrual and fertility outcomes which were associated with the use of IUD combined with other ancillary treatments. At present, the IUD is beneficial in patients with IUA, regardless of stage of adhesions. However, IUD needs to be combined with other ancillary treatments to obtain maximal outcomes, in particular in patients with moderate to severe IUA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Salma

Xue

Sheikh

et al. 2014

BioMed Research International

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“…Although good anatomical results and pregnancy rates have been reported, there have been no randomized control trials to date to confirm the usefulness of such devices. Moreover, such devices expose patients to the potential risk of perforation and infection [21][22][23][24]. To avoid leaving foreign objects in the uterus and associated complications, novel approaches using biological biodegradable anti-adhesion barriers such as ACP gel (Hyalobarrier) and Oxiplex/AP gel (Intercoat) have been developed.…”

Section: Commentsmentioning

confidence: 99%

Influence of auto-cross-linked hyaluronic acid gel on pregnancy rate and hysteroscopic outcomes following surgical removal of intra-uterine adhesions

Thubert

Dussaux

Demoulin

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Tu et al ont récemment souligné la nécessité de rétablir la fonction endométriale en complément de l'anatomie uté-rine [169]. Celui-ci étudie le développement d'un nouveau DIU reposant sur l'insertion d'une membrane à base d'acide hyaluronique avec un système de relargage d'oestrogènes et de facteurs de croissance permettant la régénération endométriale.…”

Section: Les Voies De Développementunclassified