Management of Irritable Bowel Syndrome

Torii, Akihiro; Toda, Gotaro

doi:10.2169/internalmedicine.43.353

Cited by 25 publications

(18 citation statements)

References 55 publications

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“…We did, however, find support for two risk factors for IBS (female sex and stress) that have been identified in previous studies [19,[24][25][26][27]. The predominance of females among IBS patients, and the associations with psychosocial factors such as stress, has been attributed to differences in consulting behaviour [28][29][30]. However, physiological explanations may also underpin these observations.…”

Section: Ibs In Patients With Gerdsupporting

confidence: 62%

Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

et al. 2008

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Population-based studies have shown that gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) coexist more commonly than expected by chance. We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n=6,421) or IBS (n=2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95% CI: 2.3-5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95% CI: 1.7-4.9) in the IBS cohort compared with the comparison cohort. A first diagnosis of either IBS or GERD significantly increases the risk of a subsequent diagnosis of the other condition.

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Section: Ibs In Patients With Gerdsupporting

confidence: 62%

Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

et al. 2008

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“…We subsequently divided the rats into 3 groups (n=10/group) -a control diet group, an ERF diet group, and a polycarbophil Ca (PC) diet group. In addition to anti-spasmodics and anti-cholinergic agents, PC is often used as a treatment for IBS in Japan (27). PC was chosen as a positive control in this study because it has a similar efficacy as dietary fiber due to its bulk-forming character.…”

Section: Animals and Dietsmentioning

confidence: 99%

Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

Kanauchi

Mitsuyama²,

Komiyama³

et al. 2010

Int J Mol Med

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Abstract. Irritable bowel syndrome (IBS) is a common health issue that is characterized by abdominal pain, abnormal bowel movements, altered visceral perception, and abnormal metabolism of 5-hydroxy triptamine (serotonin; 5HT). The use of prebiotics or probiotics treatment for IBS has become increasingly important as an adjunct to pharmaceutical options. The aim of this study was to determine the efficacy of enzymetreated rice fiber (ERF) on an IBS model. We obtained a new prebiotic from defatted rice bran that was developed as an insoluble dietary fiber through amylase and hemicellulase treatment followed by removal of the soluble fraction. Containing ~70% hemicellulose, ERF is utilized by lactobacilli and subsequently converted to butyrate using Eubacterium limosum. We employed a restraint stress IBS model which involved the continuous application of stress for 4 h per day for 3 days. Polycarbophil Ca (PC) (500 mg/kg body weight) was used as a positive control and ERF was added to the diet at 4% in diet. During restraint stress, ERF significantly attenuated urgent fecal excretion, colonic mucosal 5HT secretion, and hyperalgesthesia compared with the control. ERF also significantly increased cecal butyrate production as well as total organic acid content. PC was only effective in regard to preventing increases in 5HT levels. Furthermore, there were no significant levels of proinflammatory markers CINC-1 and TNF-· among the groups. Although more detailed studies are needed, the ERF prebiotic demonstrated potency in attenuating major symptoms of IBS.

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“…Additionally, we utilized bulking and constipating agents to prevent soiling and incontinence, such as calcium polycarbophil and loperamide. Calcium polycarbophil binds the water in the lumen of the intestinal tracts to prevent excessive lumping or looseness of the stools, and it can absorb approximately 70 times its original weight in water [15][16][17] . According to the pharmacotherapy of calcium polycarbophil, the clinical usefulness of this agent has been reported; however, the treatment effect of calcium polycarbophil may be insufficient for patients with excessive liquid stool [18] .…”

Section: Discussionmentioning

confidence: 99%

Functional Outcomes of Patients Treated with Intensive Medications for Bowel and Pain Control for Low-Lying Rectal Cancer Who Received Preoperative Chemoradiotherapy

Beppu

Kimura²,

Doi³

et al. 2016

Dig Surg

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Purpose: The aim of this study was to assess the functional outcomes of patients treated with intensive medications for bowel and pain control for low-lying rectal cancer who received preoperative chemoradiotherapy (CRT). Methods: The inclusion criterion was sphincter-preserving surgery following CRT for T3 middle and low rectal cancer. Postoperative defecation control was conducted using calcium polycarbophil and loperamide, and anal pain control was conducted using oxycodone hydrochloride hydrate. The functional outcomes were determined by an annual questionnaire after stoma closure. Results: Of 64 patients evaluated, 33 were reconstructed using the double stapling technique (DST) and 31 were reconstructed using the intersphincteric resection (ISR) technique. The median Visual Analogue Scale at ISR was improved from 7 to 1.5 at 1 year after surgery. The median Wexner scores were 6.0, 6.0, 5.0 and 5.0 for DST and 14.5, 12.0, 10.0 and 8.0 for ISR for the first 4 years, respectively. The only independent predictor of a poor bowel function (Wexner score >10) according to a multivariate analyses was pelvic infection (OR 3.994, 95% CI 1.235-13.52, p = 0.021), while ISR was not a predictor. Conclusions: Anal pain following ISR can be controlled with oxycodone hydrochloride hydrate therapy. ISR is feasible following CRT for low-lying rectal cancer.

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Management of Irritable Bowel Syndrome

Cited by 25 publications

References 55 publications

Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

Functional Outcomes of Patients Treated with Intensive Medications for Bowel and Pain Control for Low-Lying Rectal Cancer Who Received Preoperative Chemoradiotherapy

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