Management of low-dose aspirin and clopidogrel in clinical practice: a gastrointestinal perspective

Lanas, Ángel; Gargallo, Carla J.

doi:10.1007/s00535-015-1038-3

Cited by 25 publications

(31 citation statements)

References 107 publications

(129 reference statements)

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“…The most important outcome associated with GIB is the low adherence or even discontinuation of DAPT therapy . In the current study, a discontinuation rate of 2.91% was observed.…”

Section: Discussionsupporting

confidence: 42%

Predictors and consequences of postdischarge gastrointestinal bleeding after percutaneous coronary intervention

Zhu

Tang

Song

et al. 2018

Cardiovascular Therapeutics

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“…The most important outcome associated with GIB is the low adherence or even discontinuation of DAPT therapy . In the current study, a discontinuation rate of 2.91% was observed.…”

Section: Discussionsupporting

confidence: 42%

Predictors and consequences of postdischarge gastrointestinal bleeding after percutaneous coronary intervention

Zhu

Tang

Song

et al. 2018

Cardiovascular Therapeutics

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“…Therapy-induced senescence is an effective therapeutic strategy for malignant tumors (Ewald et al, 2010), but its clinical induction may injure the surrounding normal tissue. Since aspirin is associated with upper and lower gastrointestinal (GI) damage (Sostres et al, 2013;Lanas and Gargallo, 2015), we questioned whether such adverse effects would be present in the normal colonic epithelium following senescence-inducing aspirin treatment. Accordingly, we examined the effect of aspirin (500 mM for 72 hours) on normal colonic epithelial cells (HCoEpiC).…”

Section: Resultsmentioning

confidence: 99%

Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells

et al. 2015

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Cancer therapies attempt to destroy the entire tumor, but this tends to require toxic compounds and high doses of radiation. Recently, considerable attention has focused on therapyinduced senescence (TIS), which can be induced in cancer cells by low doses of therapeutic drugs or radiation and provides a barrier to tumor development. However, the molecular mechanisms governing TIS remain elusive. Special attention has been paid to the potential chemopreventive effect of aspirin against human colorectal cancer. In this study, we investigated the effects of aspirin on TIS of human colorectal carcinoma (CRC) cells and show that it occurs via sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK), two key regulators of cellular metabolism. Aspirin increased the senescence of CRC cells, increased the protein levels of SIRT1, phospho-AMPK (T172), and phospho-acetyl CoA carboxylase (S79), and reduced the cellular level of ATP. Small-interfering RNA-mediated downregulation or pharmacological inhibition of SIRT1 or AMPK significantly attenuated the aspirininduced cellular senescence in CRC cells. In contrast, treatment with a SIRT1 agonist or an AMP analog induced cellular senescence. Remarkably, SIRT1 knockdown abrogated the aspirin-induced activation of AMPK, and vice versa. During the progression of aspirin-induced cellular senescence in CRC cells, SIRT1 showed increased deacetylase activity at a relatively early time point but was characterized by decreased activity with increased cytoplasmic localization at a later time point. Collectively, these novel findings suggest that aspirin could provide anticancer effects by inducing senescence in human CRC cells through the reciprocal regulation of SIRT1-AMPK pathways.

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“…The risk of ibuprofen-induced gastrointestinal bleeding is higher in patients who take more than one type of NSAID simultaneously (because of a synergistic effect) and/or platelet antiaggregants/anticoagulants [35]. Other predisposing factors are a positive history of peptic ulcer or gastrointestinal bleeding, Helicobacter pylori infection, diverticulosis or chronic inflammatory bowel disease.…”

Section: Safety and Tolerability Of Ibuprofenmentioning

confidence: 99%

Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal

Martino

Chiarugi

Boner

et al. 2017

Drugs

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Ibuprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) for the treatment of inflammation, mild-to-moderate pain and fever in children, and is the only NSAID approved for use in children aged ≥3 months. Its efficacy and safety profile have led to its increasing use in paediatric care, even without medical prescription. However, an increase of suspected adverse reactions to ibuprofen has been noted in concomitance with the raised, often medically unsupervised, consumption of the drug. The purpose of this work was a critical review of the paediatric literature over the last 15 years on side effects and adverse events associated with ibuprofen, in order to highlight circumstances associated with higher risks and to promote safe and appropriate use of this drug. The literature from 2000 to date demonstrates that gastrointestinal events are rare, but (when they occur) include both upper and lower digestive tract lesions. Dehydration plays an important role in triggering renal damage, so ibuprofen should not be given to patients with diarrhoea and vomiting, with or without fever. Likewise, ibuprofen should never be administered to patients who are sensitive to it or to other NSAIDs. It is contraindicated in neonates and in children with wheezing and persistent asthma and/or during varicella. Most of the analysed studies reported adverse events when ibuprofen was being used for fever symptoms or flu-like syndrome. Ibuprofen should not be used as an antipyretic, except in rare cases. Ibuprofen remains the drug of first choice in the treatment of inflammatory pain in children.

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Management of low-dose aspirin and clopidogrel in clinical practice: a gastrointestinal perspective

Cited by 25 publications

References 107 publications

Predictors and consequences of postdischarge gastrointestinal bleeding after percutaneous coronary intervention

Predictors and consequences of postdischarge gastrointestinal bleeding after percutaneous coronary intervention

Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells

Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal

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