Management of Lung Cancer in the Elderly

Gajra, Ajeet; Akbar, Syed Ali; Din, Najam Ud

doi:10.1016/j.cger.2015.08.008

Cited by 20 publications

(21 citation statements)

References 47 publications

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“…The risk of pulmonary complications in patients with FEV1 less than 2L and less than 1L is moderate and high, respectively. PF test criteria for lobectomy are a forced expiratory volume in 1 second (FEV1) > 1.0L and maximum voluntary ventilation (MVV) > 40% of predicted [7][8][9]. In this study, the older patients had poor pulmonary function performance as compared to their counterparts, which indicated that the postoperative risk complications were higher with older patients (≥ 70 years of age) as compared to younger patients (≤ 70 years of age).…”

Section: Discussionmentioning

confidence: 77%

“…Postoperative complications after VATS may adversely affect the long-term outcomes [7][8][9]. The surgery may cause a systemic in ammatory reaction, and the level of in ammatory factors and C-reactive protein will increase [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Patients diagnosed with NSCLC in developed countries have a median age of sixty-nine and sixty-seven years in both men and women, respectively [5][6][7]. With the average age of the Chinese population on the rise, the number of elderly NSCLC patients in China is showing an increasing trend [5][6][7]. At present, the principal methods for treating NSCLC are surgery, radiotherapy, and chemotherapy [8].…”

Section: Introductionmentioning

confidence: 99%

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Short-and long-term outcomes of video-assisted thoracoscopic lobectomy in elderly patients with non-small-cell lung cancer

Yang

Wang

Ren

et al. 2020

Preprint

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Objective This study aimed to explore the short-and long-term outcomes of video-assisted thoracoscopic (VATS) lobectomy in older patients with non-small-cell lung cancer (NSCLC). Methods A total of 218 NSCLC patient data between January 2014 and January 2019, which included pathological, clinical, and follow-up surveys on VATS lobectomy, were retrospectively analyzed. Of the 218-patient data analyzed, a total of 77 patients were 70 years of age and older (elderly group), while a total of 141 patients were below 70 years of age (nonelderly group).Results Concerning general preoperative data, the simplified comorbidity score (SCS) and the American Society of Anesthesiologists (ASA) scores were higher in the elderly patient group as compared to the nonelderly patient group. Also, elderly patients had poor pulmonary function performance as compared to their counterparts. There were, however, no significant statistical differences found with surgical data between the two groups concerning intraoperative blood loss, operation duration, and conversion to thoracotomy. None of the patients in either of the groups died within thirty days of the operation. Additionally, there were no significant statistical differences in the five-year overall survival rate and the five-year disease-free survival rate between both groups.Conclusion NSCLC treatment with VATS lobectomy is safe and feasible in elderly patients, and it can provide excellent long-term outcomes. However, it is necessary to strengthen perioperative management and promote early postoperative recovery to reduce complications.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Short-and long-term outcomes of video-assisted thoracoscopic lobectomy in elderly patients with non-small-cell lung cancer

Yang

Wang

Ren

et al. 2020

Preprint

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“…Lung cancer is still a serious malignant tumor. The incidence and mortality both seem to increase with age [16], and for people ≥65 it accounts for approximately 50% of all cancer cases and cancer-caused deaths [15]. Despite extensive research and considerable medical progress, a cure for lung cancer remains elusive.…”

Section: Discussionmentioning

confidence: 99%

CA-125, CA-153, and CYFRA21-1 as clinical indicators in male lung cancer with ocular metastasis

Li¹,

Yuan²,

Zou³

et al. 2020

J. Cancer

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Despite recent improvements in diagnosis and therapy, lung cancer remains the most common malignant tumor in males, with high morbidity and mortality. As the annual incidence continues to increase worldwide, the prognosis for male patients with lung cancer remains unsatisfactory. Interestingly, smoking is associated with lung cancer and ocular lesions by altering risk factors such as carbohydrate antigen (CA)-125, CA-153 and cytokeratin-19 fragment (CYFRA21-1). A diagnostic standard for serum biomarker levels of ocular metastasis (OM) in males with lung cancer is therefore urgently needed. In this retrospective analysis, we examined the relationship between smoking preference and OM in male patients with lung cancer to identify an independent prognostic factor or establish a quantitative indicated standard for OM using the clinical indexes from 2238 cases of male lung cancer. The combination of CA-125, CA-153 and CYFRA21-1 could help diagnose OM in male lung cancer patients. This finding might lead to more timely diagnosis and effective therapies.

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“…Once a diagnosis has been made, oncologists use the principles set forth by the American Joint Committee on Cancer for lung cancer staging. There are currently 4 recognized stages of lung cancer, staged 1 -4, with stages 1, 2 and 3 being further divided into A and B subtypes [23]. Proper staging is of the utmost importance for the determination of the appropriate treatment regimen.…”

Section: Diagnosis Management and Treatment Of Lung Cancermentioning

confidence: 99%

Age-related host factors regulate lung cancer progression.

Greenwell¹

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Management of Lung Cancer in the Elderly

Cited by 20 publications

References 47 publications

Short-and long-term outcomes of video-assisted thoracoscopic lobectomy in elderly patients with non-small-cell lung cancer

Short-and long-term outcomes of video-assisted thoracoscopic lobectomy in elderly patients with non-small-cell lung cancer

CA-125, CA-153, and CYFRA21-1 as clinical indicators in male lung cancer with ocular metastasis

Age-related host factors regulate lung cancer progression.

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