Management of Multifocal and Multicentric Gliomas

Patil, Chirag G.; Eboli, Paula; Hu, Jethro

doi:10.1016/j.nec.2012.01.012

Cited by 26 publications

(28 citation statements)

References 45 publications

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“…Due to its resistance to radiotherapy and chemotherapy, the 5-year survival rate of glioma is <5%. Glioma cannot be completely cured and available treatment options are also a concern (4,5). …”

Section: Introductionmentioning

confidence: 99%

IQGAP1-siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines

Diao

Liu

Zhang

et al. 2017

Molecular Medicine Reports

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IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein, which is aberrantly expressed in several tumor types and is closely associated with the development, metastasis and prognosis of cancer. Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research of tumors. The present study aimed to explore the effects of IQGAP1-small interfering (si) NA on the proliferation and metastasis of U251 and U373 glioma cell lines, which markedly expressed IQGAP1. The human glioma cell lines (U251 and U373) were transfected with siRNA and transfection efficacy was confirmed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Cell proliferation was detected using the Cell Counting kit-8, and cell metastasis capabilities were detected using cell adhesion, migration and invasion assays. In addition, the expression levels of several tumor-associated genes were determined by RT-qPCR and western blotting. The results indicated that IQGAP1 was expressed at higher levels in glioma tissues compared with in normal brain tissues. IQGAP1-siRNA significantly inhibited cell proliferation, and cell adhesion, migration and invasion. Furthermore, the expression levels of matrix metalloproteinase (MMP)2, Snail, MMP9, fibronectin 1 and Twist were suppressed, and E-cadherin was upregulated in response to siRNA-IQGAP1. The present study identified the function of IQGAP1 in glioma cell biology, and indicated that it may be considered a novel target for glioma treatment.

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Section: Introductionmentioning

confidence: 99%

IQGAP1-siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines

Diao

Liu

Zhang

et al. 2017

Molecular Medicine Reports

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“…8 Multicentricity also imparts a worse prognosis, although the majority of multifocal and multicentric gliomas involve co-occurrence of a glioblastoma (GBM) with a grade II or III astrocytoma 9 or oligodendroglioma. 10 Predisposing factors for multicentric tumors include neurofibromatosis type I, multiple sclerosis, and radiation exposure. 11 The pathogenesis of multicentric tumors remains unclear, but has been attributed to the capacity of glioma cells to invade and migrate long distances.…”

Section: Discussionmentioning

confidence: 99%

“…11 The pathogenesis of multicentric tumors remains unclear, but has been attributed to the capacity of glioma cells to invade and migrate long distances. 10 Recent tractography investigations have also demonstrated the existence of a direct cerebello-limbic pathway whose anatomical course passes from the cerebellar cortex, underneath the thalamus, and to the medial temporal lobe via white matter tracts bordering the margin of the lateral ventricle. 12 Additional tractography studies in the setting of tumors may further elucidate the role of such pathways in the spatial migration of multicentric tumors.…”

Section: Discussionmentioning

confidence: 99%

Multicentric Low-Grade Gliomas

Sridharan

Urbanski

et al. 2015

World Neurosurgery

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“…In the past, scholars believed that MCG originated from embryonic migrating cells of neural crest, whereas others argued that MCG may result from growth or dissemination via established routes, such as white matter tracts, cerebrospinal fluid, blood, and local metastasis. 5 Geer suggested that interstitial fluid flow along white matter tracts could be a potentially important mechanism for the dissemination of MCG in 1997. 6 However, in recent years, the majority of researchers believe that MCG undergo two phases.…”

Section: Discussionmentioning

confidence: 99%

The Novel Features of Multiple Cerebral Gliomas on Magnetic Resonance Imaging

Zhang¹,

Li²,

Niu³

et al. 2015

j med imaging hlth inform

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Magnetic resonance imaging (MRI) is the golden standard for visualizing brain tumors. Cytotoxic edema and tumor angiogenesis characterize high-grade gliomas. Diffusion-weighted imaging (DWI) and contrast-enhanced scanning aid in estimating the blood supply to the tumor and the cytotoxic edema. The aim of the study was to characterize the histological grading of multiple cerebral gliomas (MCG) and the primary area affected by MCG via studying radiographic appearances by MRI imaging, including DWI signal, predilection site, and contrastenhanced scanning. Nineteen patients with MCG received MRI and contrast-enhanced MRI scanning prior to surgery. Twenty-six lesions from 20 patients included: seven astrocytomas (grade I-II) (7/26 lesions, 27%), 14 anaplastic astrocytomas (grade III) (14/26 lesions, 54%), and five glioblastomas (grade IV) (5/26 lesions, 19%). The hippocampus (hippocampal gyrus) was identified as the area most affected by the MCG in 14 of the patients (14/20 patients, 70%). In conclusion, the intensity of the DWI signal, the degree of enhancement, and the differentiation degree in the different MCG-affected areas in the same patient were inconsistent, and the progression of each lesion was varied. DWI and contrast-enhanced MRI scanning can aid in distinguishing high versus low-grade glioma. Furthermore, the results of the DWI and contrast-enhanced scanning were related to the glioma grade: a stronger DWI signal and contrast-enhanced scanning were observed in grade III-IV gliomas as compared to grade I-II gliomas. The anaplastic astrocytoma was the most common histological type, and the hippocampus (hippocampal gyrus), as a special area affected by MCG, should be noted.

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Management of Multifocal and Multicentric Gliomas

Cited by 26 publications

References 45 publications

IQGAP1-siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines

IQGAP1-siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines

Multicentric Low-Grade Gliomas

The Novel Features of Multiple Cerebral Gliomas on Magnetic Resonance Imaging

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