Management of Nasal Polyps by Steroid Nose Drops

Abstract

Systemic steroids may remove symptoms from nasal polyps in most patients, while surgery only is necessary in a few resistant cases. However. topical medication is preferable. Sprays may prevent recurrencies, but they seldom suffice for removing polyps. The aim of the present study was to document clinical efficacy of steroid nose drops. In 24 patients with nasal polyps documented by mini biopsy, aqueous budesonide (Rhinocort Aqua. Draco. Sweden) was applied as nose drops. Every second day 0.25 ml was instilled in each nostril with the head down and forward. Conventional spraying was done twice daily. The clinical condition. nasal expiratory peakjlow, and sense (?(smell was monitored for at least two months. Thefrequency (?( applying drops was decreased if smell returned or polyps disappeared while spraying continued. Afew patients were not able to comply, and afew noticed insignificant nasal bleeding. In most cases the patients were satisfied after two or three months of treatment. It is concluded that in many patients nasal polyps can be managed by budesonide nose drops. However, the results of the present pilot study should be confirmed by controlled trials before routine clinical use is justified.

Actual Concepts in Rhinosinusitis: A Review of Clinical Presentations, Inflammatory Pathways, Cytokine Profiles, Remodeling, and Management

“…Topical application of corticosteroids dramatically reduces the risk of systemic side effects [107]. Many studies have demonstrated the safety and efficacy of INS in nasal polyposis even if the intrasinus portion of the polyps is not reachable with a nasal spray [108][109][110][111][112]. Among all the specialities, mometasone furoate and fluticasone furoate are the newest and safest molecules with the lowest bioavailability.…”

Effect of Systemic Pretreatment With Betamethasone on the Bacterial Flora, Inflammatory Response, and Polyp Formation in Experimentally Infected Rabbit Maxillary Sinus Mucosa

“…Administration of corticosteroids is considered an established first‐line treatment in nasal polyposis 6,7 . Treatment with topical or systemic corticosteroids reduces the volume of small polyps and may prevent or delay the recurrence of polyps after their endonasal surgical removal 8‐11 .…”