2023
DOI: 10.1002/rmv.2421
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Management of neonatal central nervous system viral infections: Knowledge gaps and research priorities

Abstract: Congenital CMV, enteroviruses, human parechovirus and herpes simplex virus are all common causes of severe central nervous system (CNS) infection in neonates.The introduction of screening (i.e. newborn hearing screening programme), integration of molecular syndromic testing (i.e. multiplex polymerase chain reaction assays) and increase in sexually transmitted infections (i.e. anogenital herpes) have contributed to increases in each of these infections over the last decade. However, therapeutic options are high… Show more

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Cited by 4 publications
(4 citation statements)
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References 141 publications
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“…The problem of acyclovir resistance necessitates further research about novel antivirals such as brincidofovir/CMX001 (a nucleoside analogue), pritelivir, and amenamevir (both are viral helicase/primase inhibitors). 74 Brincidofovir is released into target cells, the lipid side chain is cleaved, releasing cidofovir to be further phosphorylated by intracellular kinases to cidofovir diphosphate. Cidofovir diphosphate has less renal toxicity than the parent molecule.…”
Section: Novel Treatment and Prevention Strategiesmentioning
confidence: 99%
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“…The problem of acyclovir resistance necessitates further research about novel antivirals such as brincidofovir/CMX001 (a nucleoside analogue), pritelivir, and amenamevir (both are viral helicase/primase inhibitors). 74 Brincidofovir is released into target cells, the lipid side chain is cleaved, releasing cidofovir to be further phosphorylated by intracellular kinases to cidofovir diphosphate. Cidofovir diphosphate has less renal toxicity than the parent molecule.…”
Section: Novel Treatment and Prevention Strategiesmentioning
confidence: 99%
“…The problem of acyclovir resistance necessitates further research about novel antivirals such as brincidofovir/CMX001 (a nucleoside analogue), pritelivir, and amenamevir (both are viral helicase/primase inhibitors) 74 …”
Section: Novel Treatment and Prevention Strategiesmentioning
confidence: 99%
See 2 more Smart Citations