Bedwetting is the cause of significant psychosocial stress especially in older children. Aim: The study aimed to assess the psychological impact of nocturnal enuresis on self-esteem of school children. Design: Descriptive research design was used in this study. Setting: The study was conducted in El-Menoufya University Hospital, in Egypt, which consisted of 18 outpatient clinics. The pediatric outpatient clinic of Shebin El-Kom, El-Menoufia University Hospital it is general pediatric outpatient clinic for all children disorders not just for enuresis. Sample: This is a convenient sample of 140 of children representing almost half of the total attendants with nocturnal enuresis during three months duration. The total number of the sample was 70 children of nocturnal enuresis. Tools: For data collection, an interview questionnaire was used to assess socio demographic data, children knowledge about enuresis, psychological impact of enuresis on the children regarding depression and social isolation, self-esteem inventory scale for the children. Finding: The results of the study showed there were no significant difference between gender and their positive self-esteem. In addition, there were no significant difference between psychological problems of the studied children and their positive self-esteem. Conclusion: This study concluded that children in this age have poor knowledge in relation to enuresis. In addition, most of studied children had law selfesteem. Recommendations: According to this study it is recommended that raise community awareness about nocturnal enuresis through educating adolescents in school and universities about nocturnal enuresis, development of health educational program for mothers of enuretic children. Also pediatric nurse, psychiatric nurse, community health nurse and school health nurse offer counseling services for the mothers and their children regarding nocturnal enuresis.