Management of Oxidative Stress in Animals Using Preparation Based on Trametes pubescens

Abstract

It has been determined that exposure to different stressors is associated with the development of oxidative stress, both in animals and in humans. The antioxidant defense system resists the development of oxidative stress. Basidiomycetes are the producers of a variety of biologically active compounds, including triterpene acids, exopolysaccharides, etc. Products derived from these species have immunostimulating, antitumor, antioxidant, antimetastatic action, and are effective for liver diseases treatment. The aim of the study, was to determine the antioxidant activity of Trametin to limit the stress-induced lipid peroxidation process. Antioxidant properties of Trametin (a product obtained by liquid-phase cultivation of the xylotroph fungus Trametes pubescens) were studied under experimental stress (decrease of the lighting intensity in piglets). It has been found that Trametin serves as an effective prevention of oxidative stress in stress conditions. It increases the level of unsaturation of lipids, reduces the concentration of primary and end products of lipid peroxidation, and also increases the total antioxidant activity of the blood, the activity of superoxide dismutase and reduces the glutathione level. Thus, the study of the effect of the preparation obtained by liquid-phase fermentation from fungus xylotroph of the genus Trametes pubescens showed a pronounced antioxidant effect on the model of dark stress in experimental animals, which can serve as a basis for its further application in veterinary and clinical medicine.