Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography

Cava, Maurizio La; Gharbiya, Magda; Sacchetti, Marta; Restivo, Lucia; Nardella, Chiara; Marenco, Marco

doi:10.1155/2018/1454616

Cited by 16 publications

(18 citation statements)

References 23 publications

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“…Three recent studies in Caucasians and a study in Chinese have shown that TAO patients had increased subfoveal choroidal thickness compared to normal controls . In the current study, we found that the choroidal thicknesses at 1 to 2 mm away for the fovea (except inferior 2 mm) were also significantly higher than those in normal subjects.…”

Section: Discussionsupporting

confidence: 58%

“…Three recent studies in Caucasians and a study in Chinese have shown that TAO patients had increased subfoveal choroidal thickness compared to normal controls. 6,7,17,18 In the current study, we found that the choroidal thicknesses at 1 to 2 mm away for the fovea (except inferior 2 mm) were also significantly higher than those in normal subjects. As a result of orbital soft tissue expansion, blood flow in the superior ophthalmic vein 8 and pulsatile ocular blood flow were significantly lower in TAO patients than controls.…”

Section: Discussionsupporting

confidence: 53%

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Choroidal thickness in thyroid‐associated orbitopathy

Lai

Iao

et al. 2019

Clinical Exper Ophthalmology

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Importance To investigate the choroidal thickness (CT) in patients with thyroid‐associated orbitopathy (TAO). Background To compare CT of TAO patients and healthy subjects. Design Prospective cross‐sectional study in a public hospital. Participants One hundred and four eyes of 52 TAO patients and 52 eyes of 26 healthy subjects. Methods CT was measured with enhanced‐depth imaging optical coherence tomography (EDI‐OCT) at the subfoveal, macular and peripapillary regions. Multivariate linear regression was used to evaluate the associations of subfoveal CT with systemic and ocular variables among TAO eyes. Main Outcome Measures CT of both groups. Results CT of eyes with TAO was significantly increased at the subfoveal region, 1 and 2 mm from the fovea nasally, temporally and superiorly, and 1 mm inferior to the fovea (all P < .05). No significant difference was found in CT at 2 mm inferior to the fovea (P = .094) and all four quadrants of the peripapillary region (superior, P = .096; nasal, P = .732; inferior, P = .179; temporal, P = .052). Among TAO eyes, thinner subfoveal choroid was associated with worsening exophthalmos (P = .043), poorer visual acuity (P = .017), increasing age (P = .040) and axial length (P < .001). There was no association between CT and clinical activity score (P = .239). Conclusions and Relevance TAO patients showed thicker choroid than controls over the macula, but not the peripapillary regions. Thinner subfoveal choroid was associated with worsening exophthalmos and poorer vision. EDI‐OCT can monitor choroidal vascular changes associated with TAO and its complications.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionsupporting

confidence: 53%

Choroidal thickness in thyroid‐associated orbitopathy

Lai

Iao

et al. 2019

Clinical Exper Ophthalmology

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“…Hyperthyroidism is the high level of thyroid hormones in the body due to excessive thyroid hormone synthesis by the thyroid gland (13). In the present study, we found significantly lower values in many segments of RT, CT and RNLF in the HT group compared to those of the control group.…”

Section: Discussionsupporting

confidence: 55%

Oftalmopatisiz Hipertiroidik Hastalarda Optik Cohorens Tomografi Bulguları

Eski¹,

Teberik

Sezer

et al. 2023

Sağlık Bilimlerinde Değer

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Aim The aim of this study is to compare the choroidal, retinal, and peripapillary nerve fiber layer thickness of the patients diagnosed with hyperthyroidism but did not develop ophthalmopathy with the euthyroid patients. Material and Methods: Thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) tests of the patients were analyzed. Cases who came in with symptoms of hyperthyroidism and had a TSH lower than 0.5 mu/L were included to the study. Retinal thickness (RT), retinal nerve fiber layer (RNFL) thickness, and choroidal thickness (CT) were calculated by means of spectral domain optical coherence tomography. Results: A total of 82 participants, covering 40 (49%) hyperthyroid patients and 42 (51%) euthyroid healthy individuals, were examined. In terms of RT measurements, T500,T1000,T1500 and N1500 values were found to be lower in the HT group compared to the control group, and they were statistically significant (p

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“…SS-OCT technology has shown increased depth analysis of the choroid compared to spectral-domain OCT devices, and this also may account for increased choroid thickness compared to previous studies [26]. We measured a prominent thickening of SFCT in patients with inactive GO, presenting a correlation with CAS, but Karabas et al reported a thinning of the choroid [27].…”

Section: Thickness Measurementsmentioning

confidence: 65%

Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Gravesʼ Ophthalmopathy

Kurt

Akpolat

Evliyaoglu

et al. 2021

Klin Monbl Augenheilkd

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Purpose The study was conducted for the assessment of the retinal nerve fiber layer, ganglion cell layer, and subfoveal choroidal thickness changes in patients with inactive Gravesʼ ophthalmopathy (GO) using swept-source optical coherence tomography (SS-OCT) before the development of active GO findings. Materials and Methods The cross-sectional designed study consisted of patients with inactive Gravesʼ ophthalmopathy (study group) and healthy subjects (control group). The thicknesses of the retinal ganglion cell layer, retinal nerve fiber layer, and subfoveal choroid (SFCT) were measured using SS-OCT with deep range imaging technology to compare these parameters between the study and control groups. Result Patients with inactive Gravesʼ ophthalmopathy had higher values of intraocular pressure but similar best-corrected visual acuity (p = 0.001, p = 0.232, respectively). The retinal nerve fiber layer was thinner only in the superior zone of the study group (p = 0.039), whereas similar values were noted in the temporal, nasal, and inferior areas as well as the average thickness. We did not observe any statistically significant difference in any sector of the ganglion cell layer between the study and control groups. A thicker mean subfoveal choroidal thickness value was measured in patients with inactive Gravesʼ ophthalmopathy than in healthy subjects (p = 0.013) in correlation with a clinical activity score (p = 0.046). Conclusion SS-OCT showed minimal retinal neurodegenerative alteration and significant choroidal thickening in inactive GO. Thus, SS-OCT might be a beneficial technique to detect retinal neurodegenerative and choroidal changes earlier in the stage of inactive GO before the development of active GO signs, which may affect the time and type of treatment modalities to prevent further ocular or systemic complications. Additionally, SFCT may be a good indicator for assessment of the severity of Gravesʼ disease.

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Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography

Cited by 16 publications

References 23 publications

Choroidal thickness in thyroid‐associated orbitopathy

Choroidal thickness in thyroid‐associated orbitopathy

Oftalmopatisiz Hipertiroidik Hastalarda Optik Cohorens Tomografi Bulguları

Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Gravesʼ Ophthalmopathy

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