Management of peri-implantitis

Prathapachandran, Jayachandran; Suresh, Neethu

doi:10.4103/1735-3327.104867

Cited by 174 publications

(105 citation statements)

References 23 publications

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“…These numbers are expected to increase substantially with the expected aging of the population. Treatment of P. gingivalis-mediated diseases usually includes surface debridement procedures and the administration of anti-infective agents such as chlorhexidine or antibiotics (Herrera, Sanz, Jepsen, Needleman, & Roldán, 2002;Prakasam, Elavarasu, & Natarajan, 2012;Prathapachandran & Suresh, 2012;Quirynen, Teughels, & van Steenberghe, 2003;van Winkelhoff, 2012;Xajigeorgiou, Sakellari, Slini, Baka, & Konstantinidis, 2006). However, side effects are associated with the use of chlorhexidine, such as brown discoloration of the teeth, alteration in taste, supragingival calculus formation, and, more rarely, oral mucosal erosion and parotid swelling.…”

Section: Introductionmentioning

confidence: 99%

Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis

Gerits

Spincemaille

Cremer

et al. 2017

Clinical & Exp Dental Res

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Porphyromonas gingivalis is a major pathogen involved in oral diseases such as periodontitis and peri‐implantitis. Management of these diseases typically includes mechanical debridement of the colonized surfaces followed by application of antiseptics or antibiotics. Disadvantages associated with the use of antiseptics and the growing worldwide problem of antibiotic resistance have necessitated the search for alternative agents. In this study, the antibacterial and antibiofilm properties of AM404, an active metabolite of paracetamol, were tested against P. gingivalis and other bacterial pathogens. The activity of AM404 was tested against 10 bacteria, including both oral and nonoral human pathogens. The minimal inhibitory concentration (MIC) of AM404 was determined by measuring optical density (OD) values. The minimum biofilm inhibitory concentration (MBIC) was detected by crystal violet staining. The activity of structural analogs of AM404 was tested by MIC determinations. The effect of AM404 on P. gingivalis biofilms formed on titanium disks as a model for dental implants was evaluated by colony forming unit counting. Potential cytotoxicity of AM404 towards HEK‐293 (human embryonic kidney cells), HepG2 (human hepatoma cells), IEC‐6 (rat intestinal cells), and Panc‐1 cells (pancreatic cancer cells) was assessed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assays. To get more insight in the mode of action of AM404, we used the fluorescent dyes N‐phenyl‐1‐napthylamine and SYTOX green to investigate outer and inner membrane damage of P. gingivalis induced by AM404, respectively. Of all tested pathogens, AM404 only inhibited growth and biofilm formation of P. gingivalis. Moreover, it showed potent activity against P. gingivalis biofilms formed on titanium surfaces. A structure–activity analysis demonstrated that the unsaturated carbon chain is essential for its antibacterial activity. Importantly, AM404 was not toxic towards the tested mammalian cells up to concentrations approaching 4× the MIC. Membrane damage assays using fluorescent probes N‐phenyl‐1‐napthylamine and SYTOX green revealed that membrane permeabilization presumably is the primary antibacterial mode of action of AM404. Collectively, our results suggest that AM404 has the potential to be used for the development of new drugs specifically targeting P. gingivalis‐related infections.

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Section: Introductionmentioning

confidence: 99%

Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis

Gerits

Spincemaille

Cremer

et al. 2017

Clinical & Exp Dental Res

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“…The local treatment of peri-implantitis composed of non-surgical and surgical therapy is most commonly used to control infections and/or improve osseointegration [159,160]. With the sustained drug release and better biocompatibility, DDS could be suitable for the treatment of peri-implantitis.…”

Section: Dds For Peri-implantitismentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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“…Las probabilidades de que un implante dental fracase se aumentan cuando hay una pérdida ósea mayor a 1 mm dentro del primer año y mayor de 2 mm después del primer año (Prathapachandran & Suresh, 2012), la profundidad al sondeo que por lo general se presenta es alrededor de 3 mm, sin embargo esta puede variar dependiendo del tipo de implante o bien por la localización submucosa del conector, el sondeo mayor a 4 mm puede indicar la presencia de inflamación del tejido periimplantario (García-Calderón et al).…”

Section: Introduccionunclassified

Periimplantitis: Revisión de la Literatura

García-Calderón¹,

Cornejo²,

Cuevas-González

et al. 2016

Int. J. Odontostomat.

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GARCÍA-CALDERÓN, A. G.; DONOHUE-CORNEJO, A.; CUEVAS-GONZÁLEZ, M. V.; ÁVILA-VALDÉZ, R. & CUEVAS-GONZÁLEZ, J. C. Periimplantitis: revisión de la literatura. Int. J. Odontostomat., 10(2):255-260, 2016. RESUMEN:El uso de implantes ha tomado un gran auge en los últimos años, sin embargo así como se ha visto un aumento en la demanda también se ha visto un incremento en el fracaso de los mismos, existen múltiples razones que intervienen para esto como son; deficiencias en la cantidad y calidad de hueso, patologías óseas preexistentes, mala técnica quirúrgica, implante inadecuado, hábito tabáquico, entre otras. La mucositis periimplantaria y la periimplantitis son las primeras causas de complicaciones en los implantes, los pacientes con enfermedades crónico degenerativas, fumadores y con mala higiene son considerados pacientes de riesgo para presentar periimplantitis. La literatura ofrece tratamientos quirúrgicos y no quirúrgicos los cuales van enfocados a la eliminación de microorganismos y a la desinfección de la superficie del implante, el tratamiento quirúrgico como la debridación y curetaje tienen la finalidad de eliminar la placa bacteriana, desinfectar la superficie del implante así como retirar el tejido dañado por el proceso inflamatorio, el realizar una adecuada historia clínica y valoración previa, permitirá identificar a los pacientes con mayor o menor riesgo de desarrollar periimplantitis, las citas de mantenimiento ayudan a detectar oportunamente posibles complicaciones.PALABRAS CLAVE: periimplantitis; mucositis periimplantaria; enfermedad periodontal. INTRODUCCIONEl uso de implantes ha tomado un gran auge en los últimos años, sin embargo así como se ha visto un aumento en la demanda también se ha visto un incremento en el fracaso de los mismos, existen múltiples razones que intervienen para esto como son; deficiencias en la cantidad y calidad de hueso, patologías óseas preexistentes, mala técnica quirúrgica, implante inadecuado, hábito tabáquico, entre otras, sin embargo a pesar de controlar en medida de lo posible los factores antes mencionados, se llega a presentar el fracaso en el sitio de colocación del implante, dentro de las principales causas se encuentra la periimplantitis, la cual en términos clínicos se define como un proceso inflamatorio que afecta la función fisiológica del tejido duro y blando que se encuentra alrededor de un implante osteointegrado, o en vías de la osteointegración (McCrea, 2014) (Fig. 1) y la mucositis periimplantaria, en donde se aprecia una inflamación reversible del tejido circundante al implante, sin que haya perdida de tejido óseo.La prevalencia que se conoce sobre el desarrollo de la periimplantitis es muy variada, Schmidlin et al. (2012) realizaron un estudio transversal dirigido a odontólogos en donde determinaron una prevalencia que entre del 5-6 % y 7-9 % posterior a 5 y 10 años *

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Management of peri-implantitis

Cited by 174 publications

References 23 publications

Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis

Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Periimplantitis: Revisión de la Literatura

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