Management of peri-implantitis: Remedy for the malady

Pulluri, Preetham; Mallappa, Jayasheela; Karibasappa, Sowmya Nagur; Mehta, Dhoom Singh

doi:10.4103/ijohs.ijohs_41_17

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Infection plays a major role in peri-implantitis and the failure of dental implants for those with DM. Although the administration of post-operative antibiotics as well as an oral antimicrobial rinse can control peri-implantitis for uncontrolled diabetic patients [71], there is a lack of understanding about the choice and effectiveness of systemic antibiotic drug delivery [72,73], despite the number of preventive systemic antibiotic regimens proposed to reduce infections following dental implant implantation [74].…”

Section: Bio-inspired Patterns Used To Increase Antimicrobial and Ant...mentioning

confidence: 99%

Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

et al. 2021

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Dental implants are used broadly in dental clinics as the most natural-looking restoration option for replacing missing or highly diseased teeth. However, dental implant failure is a crucial issue for diabetic patients in need of dentition restoration, particularly when a lack of osseointegration and immunoregulatory incompetency occur during the healing phase, resulting in infection and fibrous encapsulation. Bio-inspired or biomimetic materials, which can mimic the characteristics of natural elements, are being investigated for use in the implant industry. This review discusses different biomimetic dental implants in terms of structural changes that enable antibacterial properties, drug delivery, immunomodulation, and osseointegration. We subsequently summarize the modification of dental implants for diabetes patients utilizing carbon nanomaterials, which have been recently found to improve the characteristics of biomimetic dental implants, including through antibacterial and anti-inflammatory capabilities, and by offering drug delivery properties that are essential for the success of dental implants.

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Section: Bio-inspired Patterns Used To Increase Antimicrobial and Ant...mentioning

confidence: 99%

Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

et al. 2021

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“…Antibiotics or antibacterial agents, such as tetracycline, minocycline, chlorhexidine, were loaded to carriers like chips, gel, microsphere, polymeric fiber [161][162][163]. Some products like Arestin ® [164], perioChip ® [165], and Atridox ® [166] for periodontitis also showed great application potential in peri-implantitis. Recently, dual-function DDS with antibacterial and bone regeneration effect has been reported as well.…”

Section: Dds For Peri-implantitismentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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“…It is characterized clinically as symptomatic peri-apical lesion that develops within the first few months after implant insertion while the coronal portion of the implant sustains a normal bone to implant interface. It can be an active or an inactive lesion [7] .…”

Section: Retrograde Peri-implantitismentioning

confidence: 99%

“…Alfredo De Rosa [32] et al carried out in vitro study using controlled-Release material Containing Metronidazole and Doxycycline for peri-implantitis. It was concluded that newly formulated gel was effective both on planktonic species and on bacterial biofilm over a period of 13 days iv) Laser and Photodyanmic therapy: Various types of lasers have been used: neodymium-doped: yttrium aluminium garnet, Erbium: yttrium aluminium garnet (Er: YAG), CO2 and Diode laser with variable results [33] . Kotsakis et al [34] in their meta-analysis and systematic showed with a single application of either an erbium: yttrium-aluminum-garnet (Er:YAG) (2,940-nm) laser or a diode (660-nm) laser in combination with a phenothiazine chloride dye is efficient in controlling inflammation around treated implants for at least 6 months but showed no statistically significant evidence for treatment effects in reducing PD and CAL levels in comparison to controls.…”

Section: Treatment Modalities For Peri-implant Diseases Treatment Therapies For Peri-implant Mucositismentioning

confidence: 99%

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Periimplant diseases and its treatment modalities: A review

Shah¹,

Shetty²,

Dharmadhikari³

2021

Int. J. Appl. Dent. Sci.

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Dental implants are widely used and are considered to be one of the most feasible treatment options that can be used to replace missing teeth. The placement of dental implants has become a routine procedure in the oral rehabilitation of totally or partially edentulous patient. Implant treatment effectively restores normal oral function and esthetics and has overall satisfactory survival rates. However, implant therapy has certain drawbacks and risks, such as inflammation of peri-implant soft and hard tissues. This review article will provide insights regarding different treatment modalities for treating peri-implant diseases.

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Management of peri-implantitis: Remedy for the malady

Cited by 4 publications

References 3 publications

Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Periimplant diseases and its treatment modalities: A review

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