Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges
            <i>: in-vitro</i>
            and
            <i>in-vivo</i>
            evaluation

Ossama, Muhammed; Lamie, Caroline; Mohamed, Tarek; Wagdy, Hebatallah A.; Attia, Dalia; Elmazar, Mohamed M.

doi:10.1080/10717544.2020.1858999

Cited by 27 publications

(16 citation statements)

References 49 publications

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“…64,65 Chitosan-based nanosponges can be fabricated by many techniques such as freeze-drying (lyophilisation) and by introducing foaming agents during melt mixing of chitosan and nanoparticles. 65,66 Among them, a simple and efficient process is lyophilisation, which starts with freezing a solution of chitosan with or without additives followed by evaporation of the solvent under reduced pressure. 67,68 At present, there are numerous techniques available to fabricate a chitosan-based membrane or scaffold for tissue engineering such as particle salt leaching, 69,70 electrospinning, 71,72 stereolithography, 73,74 gas foaming, 75,76 freeze-drying, 57,67,75 and 3D bioprinting.…”

Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

“…The open pores can intake a large number of fluids beneficial for cell growth as well as proliferation 64,65 . Chitosan‐based nanosponges can be fabricated by many techniques such as freeze‐drying (lyophilisation) and by introducing foaming agents during melt mixing of chitosan and nanoparticles 65,66 . Among them, a simple and efficient process is lyophilisation, which starts with freezing a solution of chitosan with or without additives followed by evaporation of the solvent under reduced pressure 67,68 …”

Section: Chitosan‐based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

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Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary physico-chemical characteristics and properties. While a primary use of chitosan has been in horticultural and agricultural applications for plant defense and to increase crop yield, recent research reports display various new utilizations in the field of advanced biomedical devices, targeted drug delivery, and as bioimaging sensors. Chitosan possesses multiple characteristics such as antimicrobial properties, stimuli-responsiveness, tunable mechanical strength, biocompatibility, biodegradability, and water-solubility. Further, chitosan can be processed into nanoparticles, nano-vehicles, nanocapsules, scaffolds, fiber meshes, and 3D printed scaffolds for a variety of applications. In recent times, nanoparticles incorporated in chitosan matrices have been identified to show superior biological activity, as cells tend to proliferate/differentiate faster when they interact with nanocomposites rather than bulk or micron size substrates/scaffolds. The present article intents to cover chitosan-based nanocomposites used for regenerative medicine, wound dressings, drug delivery, and biosensing applications.

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Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Section: Chitosan‐based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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“…Adult male ICR mice (8 weeks old; weighing 25 ± 2 g) were purchased from the Animal Centre of Jiangsu University (Zhenjiang, China), housed in individual plastic cages and subjected to a 12-h light–dark cycle with 60% relative humidity at 25 ± 2 °C. A diameter of 2-mm piece of filter paper was soaked in 50% acetic acid and placed in the labial fornix region of the inferior incisors of anaesthetized mice for 60 s to form the lesion [ 22 , 23 ]. The mice were grouped into four groups, five mice one group.…”

Section: Methodsmentioning

confidence: 99%

Nattokinase crude extract enhances oral mucositis healing

et al. 2021

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Background Nattokinase (NK) is a promising alternative in the prevention and treatment of cardiovascular diseases due to its potent fibrinolytic activity. In this study, we investigated the effect of crude nattokinase extract on the healing of acetic acid-induced oral mucositis in mice. Methods Bacillus subtilis culture media (BSCM) was isolated into the supernatant, named nattokinase crude extract (NCE), and the pellet was named Bacillus subtilis mass (BSM). An oral mucositis model was established in mice by applying 50% glacial acetic acid to the buccal mucosa. According to the treatment conditions, the mice were divided into BSCM, NCE, BSM and phosphate buffered saline (PBS) groups. The weight of the mice, oral mucositis healing score and histopathological examination were used to evaluate the treatment. Results Fibrinolytic activities of BSCM, NCE and BSM were approximately 8069, 10,800 and 80 U/ml, respectively. The weight gain of mice in the NCE group was significantly different from the PBS group after three days’ treatment (p < 0.05). The oral mucositis score of NCE group was significantly higher than other groups (p < 0.05). The differences in histopathology scores between the NCE and other groups were statistically significant (p < 0.01). Conclusions NCE could possess remarkable potential to reduce pain and promote oral mucositis healing with minimal safety concerns. In this study, we first report that NCE from the supernatant of Bacillus subtilis can promote the healing of oral mucositis, which extends the application scope of NK.

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“…[132] To this end, several biomimetic mucosal models have been developed including glycan microarrays, mucin layers, synthetic polymers, [224,225] and combinations thereof. [226,227] Furthermore, the diverse properties and unique brush-like morphology of glycoproteins-mucins specifically-have bioinspired the synthesis of several biomaterials. [228] For more information.…”

Section: Additional Biomimetic and Bioinspired Applicationsmentioning

confidence: 99%

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Rahamim

Azagury

2021

Adv Funct Materials

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The main purpose herein is to provide an up-to-date review on noninvasive biomimetic, bioinspired, and bioengineered drug delivery system (DDS). Noninvasive DDS is an ever-growing field critical for the applicability of drugs. It offers noninvasive administration routes with improved controlled, targeted, and triggered drug delivery. Noninvasive DDS employ many approaches and strategies, such as, nano-and microparticles, lipid-based systems, sonophoresis, electrophoresis and iontophoresis, penetration enhancers, microneedles, and gels. The last decade seen a surge in research papers employing the paradigms of biomimicry, bioinspiration, and bioengineering. However, since the use of these terms in noninvasive DDS field is often inconsistent and unclear, some generalized perspectives are provided on the possible usage of these terms in future publications. Additionally, a critical discussion on the novelty and origins of these paradigms is provided. The advantages and disadvantages of each of the noninvasive routes and their current main limitations are summarized. The main aspects of indicated fields are discussed: The unique physiology of the related tissues, the main hurdles for mass transport, the various DDS tested, and materials selection. Finally, the basic concepts and therapeutic effects of these DDS are discussed and future venues for noninvasive biomimetic, bioinspired, and bioengineered DDS research are proposed.

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Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges : in-vitro and in-vivo evaluation

Cited by 27 publications

References 49 publications

Chitosan‐based nanocomposites for medical applications

Chitosan‐based nanocomposites for medical applications

Nattokinase crude extract enhances oral mucositis healing

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

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