Management of Recurrent Malignant Effusions

Dollinger, Malin R.

doi:10.3322/canjclin.22.3.138

Cited by 18 publications

(7 citation statements)

References 27 publications

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“…It has been reported to be the initial manifestation of the cancer in from 46% to 64% of patients [15,18]. It has been frequently stated that 50% of patients with cancer of the breast or lung will develop pleural effusion during the course of the course of the disease [7,9,19,20]. This estimate is probably excessive at present due to alteration in the natural history of these cancers by newer methods of treatment [1], Pleural effusion presents predominantly as a late manifestation in breast cancer [21].…”

Section: Incidencementioning

confidence: 99%

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Diagnosis and treatment of malignant pleural effusion

1987

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Pleural effusion is a common and important complication of malignancy which may at times be difficult to diagnose or treat. Its well recognized association with numerous diseases plus the limitations of our usual diagnostic tests may occasionally cause difficulty. In the oncology patient there are a number of common medical problems associated with the development of pleural effusion which frequently coexist with the malignancy. Pleural effusion may be a presenting or late sign of cancer, and when recurrent can be a vexing symptomatic problem. Fortunately, an increasing number of effective diagnostic and therapeutic modalities are available which, when judiciously applied, facilitate our approach.

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Section: Incidencementioning

confidence: 99%

“…Multiple (6)(7)(8) closed pleural biopsies should be obtained for special histopathologic studies. Mesothelioma is often confused with adenocarcinoma.…”

Section: Malignant Pleural Mesotheliomamentioning

confidence: 99%

Diagnosis and treatment of malignant pleural effusion

1987

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“…1. Effusions into the pleural or peritoneal spaces can be either early or late, while pericordial effusions are almost always later occurrences (Dollinger, 1972). Forty-nine of our patients eventually developed pleural effusion, 6 a peritoneal effusion, and in only one did pericordial effusion ensue (Fig.…”

Section: Methodsmentioning

confidence: 76%

The management of malignant effusions from breast cancer

Rosato

Wallach

Rosato

1974

Journal of Surgical Oncology

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We have reviewed our experience with 50 patients with malignant effusion secondary to breast cancer. Prior to any therapy for this problem the malignant cause of the effusion must be firmly established. Permanent cell block with cytologic examination of such cells proved exceedingly accurate in our hands. Once the diagnosis is known secondary to malignancy the type of effusion must be investigated since those in which there are a large number of free cells or diffuse serosal studding respond best to intracavitary therapy. Those in which the effusion is due to lymphatic or venous blockage secondary to a single large tumor mass do not respond well to intracavitary therapy. Forty‐nine of our patients had pleural effusion and were treated either by aspiration of fluid alone, aspiration of fluid combined with systemic treatment, or aspiration of fluid combined with intracavitary administration of radioactive gold, or nitrogen mustard. In the course of their therapy each patient averaged 6 thoracenteses prior to symptomatic relief, and usually remained symptom free after a course of treatment. An interval of 19 months from the time of the appearance of the effusion until death was found in the 38 patients who have succumbed to their disease ‐in the 12 who are still living 54 months have passed since initial appearance of their effusion to the present time. We believe that effusion is not a signal of the last stage of this disease and should be aggressively treated.

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“…Dollinger [2] states, however, that it is not very beneficial. The usual dose is 2-3 gm for ascites, where it has been found to be most useful.…”

Section: Combined Thoracostomy and Instillation Of Chemotherapeutic Amentioning

confidence: 99%

“…Most malignant effusions are exudates with cell counts of 100-3,000 cells/cubic centimeter. In rare instances, an effusion will be the result of free-growing cancer cells in the pleural space with a cell count over 4,000 cells/cubic centimeter [2].…”

Section: Introductionmentioning

confidence: 99%

Management of malignant pleural effusion

Greenwald

Phillips

Bennett

1978

Journal of Surgical Oncology

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A pleural effusion is a frequent complication of malignant disease. Essential to the care of oncology patients is a fundamental knowledge of the pathophysiology and treatment of such effusions. This article discusses the current thoughts concerning the occurrence of malignant effusions, outlines the current available methods and agents employed for control, and presents a modification of the thoracostomy procedure that appears to be more effective than the standard procedure.

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Management of Recurrent Malignant Effusions

Cited by 18 publications

References 27 publications

Diagnosis and treatment of malignant pleural effusion

Diagnosis and treatment of malignant pleural effusion

The management of malignant effusions from breast cancer

Management of malignant pleural effusion

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