No abstract

The PNQ has an applicable degree of feasibility and validity, useful for the diagnosis of CIPN as well as for clinical treatment decision-making, where the development of CIPN is a potential treatment-limiting consideration. Physicians underreport and underestimate the severity of CIPN symptoms compared with patients, thereby supporting the importance of assessing patient-reported outcomes using the PNQ.

Pleural effusion is a common and important complication of malignancy which may at times be difficult to diagnose or treat. Its well recognized association with numerous diseases plus the limitations of our usual diagnostic tests may occasionally cause difficulty. In the oncology patient there are a number of common medical problems associated with the development of pleural effusion which frequently coexist with the malignancy. Pleural effusion may be a presenting or late sign of cancer, and when recurrent can be a vexing symptomatic problem. Fortunately, an increasing number of effective diagnostic and therapeutic modalities are available which, when judiciously applied, facilitate our approach.

We carried out an extensive series of ab initio quantum mechanical (QM) calculations using pure effective core potential (ECP) and hybrid Hartree–Fock (HF)/ECP basis sets, including various electron correlation treatments up to the MP4 level on cis‐diamminedichloroplatinum(II), cisplatin, an important anticancer drug. The optimized geometric parameters and vibrational frequencies of cisplatin were compared with the experimental values, and the effects of varying basis sets and correlation (MP level) treatments on the geometric parameters and vibrational frequencies were analyzed. We also present a detailed description of the bonding in cisplatin using qualitative MO analysis to characterize the key intramolecular interactions in cisplatin. The calculated molecular electrostatic potential (MEP), and the electrostatic potential (ESP) charges for cisplatin were used to identify regions of electrophilic and nucleophilic character. The charge density and the Laplacian of charge density of cisplatin were calculated to determine its bonding relationships. Using basis set performance, we identified two hybrid basis sets (HF/6‐311G* and MP2/6‐311G*) as basis sets of choice for studying cisplatin's molecular properties. Furthermore, we recommend a hybrid ECP/HF approach with electron correlation for the most accurate physicochemical and electronic description of cisplatin and related compounds. ©1999 John Wiley & Sons, Inc. J Comput Chem 20: 365–382, 1999

Patient-reported CIPN was significantly more severe with single-agent adjuvant taxane compared to AC followed by taxane treatment; however, the HRQOL findings support that single-agent taxane treatment is tolerable.