Management of Recurrent Prostate Cancer After Radiotherapy: Results From Calgb 9687, a Contemporary Prospective Multi-Institutional Salvage Radical Prostatectomy Series

Sokoloff, Mitchell H.; Steinberg, Gary D.; Halabi, Susan; Sanford, Ben; Eastham, James A.; Mohler, James L.; Walther, Phillip J; Carroll, Peter R.; Vogelzang, Nicholas J.; Small, Eric J.

doi:10.1016/s0022-5347(08)61892-3

Cited by 2 publications

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“…The biochemical failurefree survival rates at 5 and 7 years have been reported at 77 and 69%, respectively. 14 In this paper we will review salvage HIFU as a promising minimally invasive alternative for the treatment of biochemical failure after primary radiotherapy for localized prostate cancer, and we will compare it with more recent results from salvage prostatectomy 15 and salvage cryotherapy 16 series.…”

Section: Introductionmentioning

confidence: 99%

Salvage HIFU for recurrent prostate cancer after radiotherapy

Chalasani

Martínez

Lim

et al. 2008

Prostate Cancer Prostatic Dis

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Recurrent disease following primary radiotherapy for localized prostate cancer is a common problem, occurring in up to 46% of patients. For these patients, therapeutic options include salvage prostatectomy, salvage cryotherapy, salvage high-intensity focused ultrasound (HIFU), hormonal therapy or observation. This review will focus on the emerging evidence for salvage HIFU. There are no randomized or prospective studies in this area. Efficacy results of 17-57% have been reported from retrospective case series, with reported toxicity including rectal fistula in 0-16%, and incontinence in 10-50%. The ideal patient, while yet to be clearly defined, should have preradiotherapy low or intermediate risk disease. Salvage HIFU appears most appropriate for those patients with histologically proven local recurrence only, with a life expectancy of at least 5 years and with some medical comorbidities rendering them not ideal for salvage prostatectomy.

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Section: Introductionmentioning

confidence: 99%