Management of regional metastatic disease in cutaneous malignancy of the head and neck. 3. Merkel cell carcinoma

Bowe, C.M.; Gurney, Ben; Whitaker, S.; Newlands, Carrie

doi:10.1016/j.bjoms.2019.08.022

Cited by 4 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgery is the preferred treatment option for patients with CSCC (5). Although surgical resection can eliminate small superficial tumor lesions, lymphadenectomy of the removal of the regional draining lymph node is necessary for cancer cases with high risks of lymph node invasion (6,7). The risk of nodal metastasis (NM) in cohort and tumor registry studies has ranged from 2.0 to 5.8%.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑27b‑3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP‑13

Liang

Zhang

2021

Oncol Lett

View full text Add to dashboard Cite

Cutaneous squamous cell carcinoma is a common malignant tumor. The aim of the present study was to examine the biological function of microRNA (miR)-27b-3p in cutaneous squamous cell carcinoma (CSCC) and its underlying mechanism. The relative expression levels of miR-27b-3p were determined in A-431, Colo-16 and NHEK/SVTERT3-5 cell lines. The regulatory effects of miR-27b-3p on the proliferation of CSCC cells were evaluated using MTT and colony formation assays. Transwell assays were conducted to examine the role of miR-27b-5p in the migratory and invasive abilities of CSCC cells. The levels of EGFR, MMP-13, Akt, phosphorylated (p)-Akt, cyclin D1, N-cadherin (CAD) and E-CAD were detected in CSCC cells using reverse transcription-quantitative PCR and western blot analysis. Binding between miR-27b-3p and the 3'-untranslated region (UTR) of EGFR or MMP-13 was assessed using a dual-luciferase reporter assay. miR-27b-3p was significantly downregulated in CSCC cell lines, compared with the skin keratinocyte cell line. Transfection with a miR-27b-3p mimic significantly reduced the proliferative, migratory and invasive abilities of CSCC cells in vitro. Moreover, miR-27b-3p mimic transfection downregulated the mRNA and protein levels of EGFR, MMP-13, cyclin D1, p-Akt and N-CAD, whilst upregulating E-CAD levels in CSCC cells. miR-27b-3p was found to target the EGFR and MMP-13 3'-UTRs, thus downregulating the expression of these molecules. The inhibition of CSCC proliferation by miR-27b-3p was effectively reversed by EGFR overexpression. Moreover, the inhibitory effect of miR-27b-3p on the migratory and invasive abilities of CSCC cells was abolished by MMP-13 overexpression. In conclusion, miR-27b-3p inhibits the proliferation, migration and invasion of CSCC cells by downregulating the expression of EGFR and MMP-13 and may represent a potential diagnostic marker and therapeutic option for CSCC.

show abstract

Section: Introductionmentioning

confidence: 99%

MicroRNA‑27b‑3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP‑13

Liang

Zhang

2021

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…As one might expect, again, the exact extent of dissection is unknown for this rare tumor. As a result, one study applied a similar approach regarding the level of parotidectomy and neck dissection for cSCC to MCC, citing that it is at least as aggressive, if not more [121]. There was one specific study from the Moffit Cancer Center (Tampa, FL, USA), however, that found improved locoregional control and disease-specific survival in patients who underwent postoperative RT with pathologic or clinically positive lymph nodes, but not in patients with negative lymph nodes [122].…”

Section: Merkel Cell Carcinomamentioning

confidence: 99%

Lymph Node Metastases from Non-Melanoma Skin Cancer of the Head and Neck

Civantos,

Helmen,

Bradley

et al. 2023

Cancers

View full text Add to dashboard Cite

Non-melanoma skin cancer (NMSC) represents the most common malignancy in the world, comprising exceedingly common lesions such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) and rare lesions such as Merkel cell carcinoma. Risk factors are widely recognized and include ultraviolet (UV) light exposure, radiation exposure, immunosuppression, and many others. As a whole, survival and functional outcomes are favorable, but each histopathological subtype of NMSC behaves differently. Treatment regimens for the primary site usually include wide surgical excision and neck dissection in cases of clinically involved metastatic lymph nodes. The elective management of draining nodal basins, however, is a contested topic. Nearly all subtypes, excluding BCC, have a significant risk of lymphatic metastases, and have been studied with regard to sentinel lymph node biopsy (SLNB) and elective neck dissection. To date, no studies have definitively established a true single standard of care, as exists for melanoma, for any of the NMSCs. As a result, the authors have sought to summarize the current literature and identify indications and management options for the management of the cervical lymphatics for each major subtype of NMSC. Further research remains critically necessary in order to develop complete treatment algorithms.

show abstract

“…In about one-third of patients with MCC of the neck the regional lymph nodes are involved (stage III disease). This includes cases detected at SLNB, cases with clinically-detected and confirmed involvement of the regional lymph nodes or in-transit metastases (27).…”

Section: Management Of Regional Lymph Nodesmentioning

confidence: 99%

“…CLND should extend to nodal levels in which there is a high risk of occult nodal disease, include involved parotid tissue and involved levels in the neck (27).…”

Section: Management Of Regional Lymph Nodesmentioning

confidence: 99%

A Therapeutic and Diagnostic Multidisciplinary Pathway for Merkel Cell Carcinoma Patients

et al. 2020

View full text Add to dashboard Cite

Merkel Cell Carcinoma (MCC) is a highly aggressive neuroendocrine neoplasm of the skin. Due to its rarity, the management of MCC is not standardized across centers. In this article, we present the experience of the Veneto region in the NorthEast of Italy, where a committee of skin cancer experts has proposed a clinical pathway for the diagnosis and treatment of MCC. Putting together the evidence available in the international literature, we outlined the best approach to the management of patients affected with this malignancy step-by-step for each possible clinical situation. Crucial in this pathway is the role of the multidisciplinary team to deal with the lack of robust information on each aspect of the management of this disease.

show abstract

Management of regional metastatic disease in cutaneous malignancy of the head and neck. 3. Merkel cell carcinoma

Cited by 4 publications

References 52 publications

MicroRNA‑27b‑3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP‑13

MicroRNA‑27b‑3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP‑13

Lymph Node Metastases from Non-Melanoma Skin Cancer of the Head and Neck

A Therapeutic and Diagnostic Multidisciplinary Pathway for Merkel Cell Carcinoma Patients

Contact Info

Product

Resources

About