Management of sinonasal chondrosarcoma: a systematic review of 161 patients

Abstract

This review contains the largest pool of sinonasal chondrosarcoma patients to date and suggests aggressive surgical resection is the most common treatment modality for this condition. The use of adjuvant radiotherapy for prevention of local recurrence after subtotal or total resection has not been proven effective. However, the use of radiotherapy in addition to surgical resection has shown benefit in some studies in terms of survival.

Head and neck sarcomas: the UCLA experience

“…This is in agreement with the current literature on chondrosarcoma of the head and neck, which emphasizes the importance of negative margins and grade on survival and treatment outcomes [6]. …”

The role of systemic therapy in the management of sinonasal cancer: A critical review

“…No conclusions on the efficacy of systemic therapy could be made [78] and the role of systemic treatment in the management of this disease seems to be limited.…”

Intracranial Chondrosarcoma Resected Via an Extended Endoscopic Endonasal Approach

“…The literature regarding surgical management of chondrosarcomas is limited to small case series with a systematic review bringing together only 161 cases (Khan et al, 2013). There is a paucity of consensus regarding the most efficacious surgical approaches to chondrosarcomas located in the clival region.…”

“…The use of adjuvant radiation therapy combination with surgery is increasingly utilised, reportedly employed in sinonasal chrondrosarcomas diagnosed after 1990 (Khan et al, 2013). there is a lack of conclusive statistical evidence given the rarity of these tumours, There are various radiotherapy modalities available including fractionated photon radiotherapy, proton therapy, particle therapy with ions and stereotactic radiosurgery.…”

“…Whilst this is consistent with previous studies (Oghalai et al, 2005, Colli and Al-Mefty, 2001), the largest study of intracranial chondrosarcoma, by Rosenberg et al, 1999, demonstrates a 5-year survival of 99% when surgery is combined with adjuvant radiotherapy (Rosenberg et al, 1999). Intracranial Chondrosarcomas arise predominantly at the base of the skull with the most common location being the clivus (32%) followed by the temporo-occipital junction (Bloch et al, 2009, Khan et al, 2013. The predilection for the skull base is thought to be related to the difference in bone development as endochondral ossification predominates in the basilar structures of the skull compared to intramembranous ossification in other areas (Bloch and Parsa, 2013).…”