Management of stage I cervical sarcoma botryoides in childhood and adolescence

Gruessner, S.; Omwandho, Charles; Dreyer, Thomas; Blütters-Sawatzki, R.; Reiter, Alfred; Tinneberg, H.‐R.; Bohle, Rainer M.

doi:10.1007/s00431-004-1469-y

Cited by 45 publications

(24 citation statements)

References 27 publications

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“…Most patients present with vaginal bleeding or a sensation of a mass in the introitus. 5 The histological findings of sarcoma botryoides of the uterine cervix are similar to the ones which occur in other organs. These findings consist of rhabdomyoblasts of varying differentiation dispersed within a loose, myxoid stroma.…”

Section: Discussionsupporting

confidence: 59%

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

Mousavi

Akhavan

2010

J Gynecol Oncol

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Sarcoma botryoides (embryonal rhabdomyosarcoma) rarely arises in the uterine cervix. We report a case of a 14-yearold female with sarcoma botryoides who presented with prolonged vaginal bleeding and cervical polyp. The biopsy specimen confirmed sarcoma botryoides. The patient underwent radical surgery of the tumor and hysterectomy without adjuvant chemotherapy. The sister of the patient had died previously due to the same diagnosis at the age of 17. We achieved a satisfactory outcome in short-term period with radical surgery and hysterectomy. Presence of sarcoma botryoides of the cervix in two sisters in the family highlights the possible role of genetic factors in the development of sarcoma botryoides.

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Section: Discussionsupporting

confidence: 59%

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

Mousavi

Akhavan

2010

J Gynecol Oncol

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“…In the 1970s, pelvic exenteration was the primary treatment [3]. Current options include chemotherapy and local excision for certain cervical tumors [5][6][7][8][9][10][11][12][13]. However, local excision is not an option for uterine RMS, due to their more aggressive behavior and poor accessibility.…”

Section: Discussionmentioning

confidence: 99%

Robotic radical hysterectomy and pelvic lymphadenectomy for uterine rhabdomyosarcoma

2008

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Mullerian rhabdomyosarcoma (RMS) is a rare malignancy most commonly diagnosed in childhood and adolescence. RMS of the female genital tract is often difficult to diagnose. Treatment includes chemotherapy with adjuvant surgery and/or radiation therapy reserved for persistent disease. We report a case of an 18-year-old African-American female who presented with severe menometrorrhagia, and was diagnosed with embryonal rhabdomyosarcoma of the uterus. After vincristine, dactinomycin, and cyclophosphamide failed to eradicate the central tumor, she underwent a robotic radical hysterectomy and pelvic lymphadenectomy. Mullerian rhabdomyosarcoma was once managed with multimodality therapy that often included ultraradical surgery including total pelvic exenteration. Surgical procedures that were exclusively performed via large abdominal incisions can now be completed with minimally invasive techniques. Robotic surgery can be safely and successfully applied to radical hysterectomy and lymphadenectomy for uterine rhabdomyosarcoma.

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“…If the primary tumor completely arises from a favorable site such as the vagina and is completely excised, the overall 3-year survival rate is greater than 90% (11). In addition, depending on the stage of the tumor, a combination of chemotherapy, radiation, and surgery not only have demonstrated excellent survival rates but also often preserve complete function of surrounding organs (12).…”

Section: Discussionmentioning

confidence: 99%

Sarcoma botryoides: MRI findings in two patients

Kobi

Khatri

Edelman

et al. 2009

Magnetic Resonance Imaging

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We report the magentic resonance (MR) findings of sarcoma botryoides in two young pediatric patients with this tumor. There has been very little literature regarding the MR appearance of this subtype of rhabdomyosarcoma. In both cases, the tumor was vaginal in origin, as would be expected in this age group. We found areas of bright T2 signal within these lesions, intermixed with areas of lower T2-signal tissue, which showed considerable enhancement. These imaging findings are reflective of the histologic architecture of these lesions, which are composed of separate myxoid and subepithelial cellular zones. In both cases, the extent of the tumor and lack of local invasion or metastatic disease were confirmed surgically, and both patients have undergone multiple postoperative MR studies that have shown lack of residual, recurrent, or metastatic disease.

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Management of stage I cervical sarcoma botryoides in childhood and adolescence

Abstract: based on the literature review and our own observation, we recommend minor surgical approaches in combination with chemotherapy as the treatment of choice for early stage I cervical rhabdomyosarcoma.

Cited by 45 publications

References 27 publications

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

Robotic radical hysterectomy and pelvic lymphadenectomy for uterine rhabdomyosarcoma

Sarcoma botryoides: MRI findings in two patients

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