Management of temporomandibular joint disorders: A surgeon's perspective

Dimitroulis, George

doi:10.1111/adj.12593

Cited by 101 publications

(89 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stress bearing joints of the body, such as the hip and knee, are most commonly affected, but the TMJ is affected as well. TMJ osteoarthritis alters the condylar and glenoid fossa cartilage, subchondral bone, articular disc, and the synovial membrane that, in turn, cause pain and dysfunctional jaw movement [12,[73][74][75][76]. There are several contributing factors to TMJ OA inception and progression, including parafunction, occlusion, psychosocial aspects, trauma, and genetics.…”

Section: Hh Signaling In Degenerative Tmjsmentioning

confidence: 99%

The Roles of Indian Hedgehog Signaling in TMJ Formation

Bechtold

Kurio

Nah

et al. 2019

IJMS

View full text Add to dashboard Cite

The temporomandibular joint (TMJ) is an intricate structure composed of the mandibular condyle, articular disc, and glenoid fossa in the temporal bone. Apical condylar cartilage is classified as a secondary cartilage, is fibrocartilaginous in nature, and is structurally distinct from growth plate and articular cartilage in long bones. Condylar cartilage is organized in distinct cellular layers that include a superficial layer that produces lubricants, a polymorphic/progenitor layer that contains stem/progenitor cells, and underlying layers of flattened and hypertrophic chondrocytes. Uniquely, progenitor cells reside near the articular surface, proliferate, undergo chondrogenesis, and mature into hypertrophic chondrocytes. During the past decades, there has been a growing interest in the molecular mechanisms by which the TMJ develops and acquires its unique structural and functional features. Indian hedgehog (Ihh), which regulates skeletal development including synovial joint formation, also plays pivotal roles in TMJ development and postnatal maintenance. This review provides a description of the many important recent advances in Hedgehog (Hh) signaling in TMJ biology. These include studies that used conventional approaches and those that analyzed the phenotype of tissue-specific mouse mutants lacking Ihh or associated molecules. The recent advances in understanding the molecular mechanism regulating TMJ development are impressive and these findings will have major implications for future translational medicine tools to repair and regenerate TMJ congenital anomalies and acquired diseases, such as degenerative damage in TMJ osteoarthritic conditions.

show abstract

Section: Hh Signaling In Degenerative Tmjsmentioning

confidence: 99%

The Roles of Indian Hedgehog Signaling in TMJ Formation

Bechtold

Kurio

Nah

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…This review offers a new approach for future studies focusing on targeting the TNF-TNFR2 interactions to suppress the immune response and to reduce the pain in patients with TMDs. The hypothesized role of TNF-TNFR2 interactions in suppression the inflammatory response in TMDs (Partially adapted from Dimitroulis, 2018 [132]). (A) Owning to their role in suppression the immune response (i.e., Teffs), the inhibition of Tregs growth and development expected to be negatively associated with the severity of inflammation and pain in patients with TMD.…”

Section: Resultsmentioning

confidence: 99%

Biomarkers for Temporomandibular Disorders: Current Status and Future Directions

et al. 2020

View full text Add to dashboard Cite

Numerous studies have been conducted in the previous years with an objective to determine the ideal biomarker or set of biomarkers in temporomandibular disorders (TMDs). It was recorded that tumour necrosis factor (TNF), interleukin 8 (IL-8), IL-6, and IL-1 were the most common biomarkers of TMDs. As of recently, although the research on TMDs biomarkers still aims to find more diagnostic agents, no recent study employs the biomarker as a targeting point of pharmacotherapy to suppress the inflammatory responses. This article represents an explicit review on the biomarkers of TMDs that have been discovered so far and provides possible future directions towards further research on these biomarkers. The potential implementation of the interactions of TNF with its receptor 2 (TNFR2) in the inflammatory process has been interpreted, and thus, this review presents a new hypothesis towards suppression of the inflammatory response using TNFR2-agonist. Subsequently, this hypothesis could be explored as a potential pain elimination approach in patients with TMDs.

show abstract

“…Approximately 60-70% of the general population will experience some form of TMD in their lifetime, though only 5% of people with symptoms of TMD will actually seek treatment. 1,3 TMD can occur in patients of any age; however, the most common time of presentation is between the ages of 20 to 40 years. 1 Males are equally as likely as females to experience symptoms but females have a higher reporting rate.…”

Section: Demographicsmentioning

confidence: 99%

“…4 It is important to reassure the patient of the benign nature of the condition. 3 It has been documented that conservative therapy is effective in 68-95% of patients suffering from TMD. 7 The following advice should be discussed with the patient:…”

Section: Management Optionsmentioning

confidence: 99%