The subject of the study is organizational, managerial, socio-economic relations that arise in Russian regions and municipalities during the implementation of investment projects under the conditions of sanctions. The purpose of the study is to analyze and develop recommendations for regional and municipal authorities on attracting investments in the conditions of severe sanctions pressure from “Western” countries on the Russian Federation. The article uses empirical research methods to identify, analyze new trends and best practices in attracting investment to Russian regions and municipalities. The authors examine in detail such aspects of the research topic as the increasing importance of attracting investment to municipalities and regions due to a significant reduction in foreign direct investment due to the imposed sanctions. Particular attention is paid to identifying sources of investment capital in Russia and in “friendly” countries. As well as creating conditions for the implementation of investment projects in Russian regions and municipalities under unprecedented sanctions restrictions. To activate investment processes, it is necessary to ensure: the development and implementation of development strategies for municipalities and regions; identification and use of “unique” natural, industrial and human resources; development of investment infrastructure; creating conditions for the relocation of modern production complexes from large cities; the preferred choice of investors from “friendly” countries and representatives of domestic businesses returning capital from Western offshores; formation of special economic zones in the regions. The novelty of the study lies in the fact that, based on an analysis of the best domestic practices, specific recommendations have been developed for regional and municipal authorities on searching and attracting investment resources to Russian regions and municipalities under the conditions of “strict” sanctions restrictions. The use of research results makes it possible to intensify the processes in regions and municipalities: attracting modern high-tech economic facilities; increasing production and financial potential; improving the quality of life of the population, etc.